Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain

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dc.contributor.authorAkdag, Mehmet Zulkuf
dc.contributor.authorDasdag, Suleyman
dc.contributor.authorUlukaya, Engin
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorKurt, Mustafa Ayberk
dc.contributor.authorTaskin, Abdullah
dc.date.accessioned2024-04-24T16:02:37Z
dc.date.available2024-04-24T16:02:37Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was aimed to investigate the effect of extremely low-frequency magnetic field (ELF-MF) on apoptosis and oxidative stress values in the brain of rat. Rats were exposed to 100 and 500 mu T ELF-MF, which are the safety standards of public and occupational exposure for 2 h/day for 10 months. Brain tissues were immunohistochemically stained for the active (cleaved) caspase-3 in order to measure the apoptotic index by a semi-quantitative scoring system. In addition, the levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OS!) were measured in rat brain. Final score of apoptosis and MPO activity were not significantly different between the groups. CAT activity decreased in both exposure groups (p<0.05), while TAC was found to be lower in ELF 500 group than those in ELF-100 and sham groups (p<0.05). MDA, TOS, and OSI values were found to be higher in ELF-500 group than those in ELF-100 and sham groups (p<0.05). In conclusion, apoptosis was not changed by long-term ELF-MF exposure, while both 100 and 500 mu T ELF-MF exposure induced toxic effect in the rat brain by increasing oxidative stress and diminishing antioxidant defense system.en_US
dc.identifier.doi10.1007/s12011-010-8615-3
dc.identifier.endpage249en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1-3en_US
dc.identifier.pmid20177816
dc.identifier.scopus2-s2.0-78649326519
dc.identifier.scopusqualityQ1
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-010-8615-3
dc.identifier.urihttps://hdl.handle.net/11468/14860
dc.identifier.volume138en_US
dc.identifier.wosWOS:000284382500025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtremely Low-Frequency Magnetic Fielden_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidant Enzymeen_US
dc.subjectCaspase-3 Activitiesen_US
dc.subjectBrainen_US
dc.titleEffects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brainen_US
dc.titleEffects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain
dc.typeArticleen_US

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