Investigation of antioxidant effects of rosmarinic acid on liver, lung and kidney in rats: A biochemical and histopathological study

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dc.authorid0000-0001-7317-5467en_US
dc.authorid0000-0002-0547-4139en_US
dc.authorid0000-0003-4551-8439en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorOǧuz, Abdullah
dc.contributor.authorBöyük, Abdullah
dc.contributor.authorEkinci, Aysun
dc.contributor.authorAlabalık, Ulaş
dc.contributor.authorTürkoǧlu, Ahmet
dc.contributor.authorTuncer, Cudi M.
dc.contributor.authorEkingen, Arzu
dc.contributor.authorDeveci, Engin
dc.contributor.authorGültürk, Barış
dc.contributor.authorAday, U.
dc.date.accessioned2021-06-30T11:04:32Z
dc.date.available2021-06-30T11:04:32Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractBackground: The aim of the study was to investigate the protective effects of rosmarinic acid in rats exposed to hepatic ischaemia/reperfusion (I/R) injury. Materials and methods: Thirty-two rats were randomly classified into four groups of 8 rats each: laparotomy without medication, rosmarinic acid (dose of 50 mg/kg via oral gavage) followed by laparotomy, laparotomy followed by hepatic I/R, and hepatic I/R with rosmarinic acid. Serum aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels and total oxidant activity and total antioxidant capacity levels of the liver, lung, and kidney were assessed. The histopathologic assessment was also performed. Results: Rosmarinic acid significantly reduced liver function test parameters and decreased oxidative stress and abnormal histopathologic findings in the liver. The oxidative stress in the lung significantly increased in the I/R group but significantly decreased in the I/R + rosmarinic acid group due to the addition of rosmarinic acid. Rosmarinic acid led to no reduction in oxidative stress in kidney following hepatic I/R injury. There were no statistically significant differences among the groups regarding histopathologic changes in kidney and lung sections. Conclusions: Rosmarinic acid has antioxidant properties and is an effective hepatoprotective agent. However, although rosmarinic acid provides useful effects in the lung by increasing antioxidant capacity and reducing oxidative stress after I/R injury, it does not ameliorate histopathologic changes. These findings suggest that rosmarinic acid is likely to provide favourable outcomes in the treatment of hepatic I/R injury. Copyrighten_US
dc.identifier.citationOǧuz, A., Böyük, A., Ekinci, A., Alabalık, U., Türkoǧlu, A., Tuncer, C. M. ve diğerleri. (2020). Investigation of antioxidant effects of rosmarinic acid on liver, lung and kidney in rats: A biochemical and histopathological study. Folia Morphologica, 79(2), 288-295.en_US
dc.identifier.doi10.5603/FM.a2019.0087
dc.identifier.endpage295en_US
dc.identifier.issn0015-5659
dc.identifier.issn1644-3284
dc.identifier.issue2en_US
dc.identifier.pmid31436305
dc.identifier.scopus2-s2.0-85086135384
dc.identifier.scopusqualityQ2
dc.identifier.startpage288en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/65090
dc.identifier.urihttps://hdl.handle.net/11468/7185
dc.identifier.volume79en_US
dc.identifier.wosWOS:000541424000013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOǧuz, Abdullah
dc.institutionauthorEkinci, Aysun
dc.institutionauthorAlabalık, Ulaş
dc.institutionauthorTuncer, Cudi M.
dc.institutionauthorDevecí, Engin
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Morphologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatic ischaemia-reperfusionen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectLungen_US
dc.subjectOxidant and antioxidant capacityen_US
dc.subjectRosmarinic aciden_US
dc.titleInvestigation of antioxidant effects of rosmarinic acid on liver, lung and kidney in rats: A biochemical and histopathological studyen_US
dc.titleInvestigation of antioxidant effects of rosmarinic acid on liver, lung and kidney in rats: A biochemical and histopathological study
dc.typeArticleen_US

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