Urinary kidney injury molecules in children with febrile seizures

Basit Öğe Kaydı
dc.authorid0000-0001-6878-9325en_US
dc.authorid0000-0002-9232-5982en_US
dc.authorid0000-0003-2813-1064en_US
dc.authorid0000-0002-0760-5681en_US
dc.contributor.authorGüneş, Ali
dc.contributor.authorEce, Aydın
dc.contributor.authorAkça, Halise
dc.contributor.authorAktar, Fesih
dc.contributor.authorMete, Şehmus
dc.contributor.authorSamancı, Serhat
dc.contributor.authorUluca, Ünal
dc.contributor.authorŞen, Velat
dc.contributor.authorTan, İlhan
dc.contributor.authorKaplan, İbrahim
dc.date.accessioned2024-03-26T10:12:19Z
dc.date.available2024-03-26T10:12:19Z
dc.date.issued2016en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: Hypoxia occurs following convulsions, and hypoxia is one of the most common causes of acute renal damage. The aim of this study was to investigate urinary levels of kidney injury molecules, including neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with febrile seizures (FS) for the first time. Methods: The study included 28 children with FS and 34 age and gender matched healthy children. Serum biochemistry and blood gases were measured in the serum samples. Estimated glomerular filtration rate (eGFR) was calculated. NGAL, NAG, L-FABP, and creatinine (Cr) were measured in the urine samples. The ratios of kidney injury markers to urinary Cr were used for comparisons. Results: There were no significant differences in eGFR and serum chemistry values between the FS and the control group (p > 0.05). Hypoxia was detected in 67.9% of the FS patients. The FS group had significantly higher urinary kidney injury molecules to Cr ratios compared to the controls, including NGAL/Cr (17.9 ± 9.8; 6.7 ± 4.0, respectively; p < 0.001), NAG/Cr (0.55 ± 0.29; 0.21 ± 0.16, p < 0.001), and L-FABP/Cr (4.85 ± 2.93; 1.74 ± 1.16, p < 0.001). Conclusion: Increased urinary NGAL/Cr, NAG/Cr, and L-FABP/Cr values, in patients with FS compared to healthy controls, suggest a possible subclinical renal damage in these patients.en_US
dc.identifier.citationGüneş, A., Ece, A., Akça, H., Aktar, F., Mete, Ş., Samancı, S. ve diğerleri. (2016). Urinary kidney injury molecules in children with febrile seizures. Renal Failure, 38(9), 1377-1382.en_US
dc.identifier.doi10.1080/0886022X.2016.1215198
dc.identifier.endpage1382en_US
dc.identifier.issn0886-022X
dc.identifier.issue9en_US
dc.identifier.pmid27557879
dc.identifier.scopus2-s2.0-84983494440
dc.identifier.scopusqualityQ2
dc.identifier.startpage1377en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1215198
dc.identifier.urihttps://hdl.handle.net/11468/13719
dc.identifier.volume38en_US
dc.identifier.wosWOS:000388932600010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüneş, Ali
dc.institutionauthorEce, Aydın
dc.institutionauthorAktar, Fesih
dc.institutionauthorUluca, Ünal
dc.institutionauthorŞen, Velat
dc.institutionauthorTan, İlhan
dc.institutionauthorKaplan, İbrahim
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFebrile convulsionen_US
dc.subjectKidney injuryen_US
dc.subjectL-FABPen_US
dc.subjectNAGen_US
dc.subjectNGALen_US
dc.subjectUrinary markersen_US
dc.titleUrinary kidney injury molecules in children with febrile seizuresen_US
dc.titleUrinary kidney injury molecules in children with febrile seizures
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Urinary kidney injury molecules in children with febrile seizures.pdf
Boyut:
769.14 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Dahili Tıp Bilimleri Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu