Coronary Flow Velocity Reserve in Patients with Ascending Aorta Aneurysm

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dc.contributor.authorBaykan, Ahmet Oytun
dc.contributor.authorKalkan, Gulhan Yuksel
dc.contributor.authorGur, Mustafa
dc.contributor.authorUcar, Hakan
dc.contributor.authorAcele, Armagan
dc.contributor.authorSeker, Taner
dc.contributor.authorSen, Omer
dc.date.accessioned2024-04-24T17:11:27Z
dc.date.available2024-04-24T17:11:27Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackgroundAscending aorta aneurysms (AAA) are one of the leading causes of morbidity and mortality. Impairment in coronary flow may contribute to cardiovascular consequences in AAA patients. Coronary flow velocity reserve (CFVR) has been considered an important diagnostic index of the functional capacity of coronary arteries noninvasively. The aim of this study was to evaluate, by noninvasive CVFR, whether patients with AAA demonstrate significant coronary microvascular dysfunction in the absence of coronary artery disease (CAD). MethodsWe prospectively included 44 patients with thoracic AAA in the absence of concomitant CAD (30 men, 14 women; mean age 57.58.4years). A total of 36 patients without aortic dilatation (mean age 55.29.9years) were selected as the control group. Coronary flow velocities in the distal left anterior descending (LAD) artery were measured using transthoracic echocardiography. CFVR was calculated as the hyperemic to resting coronary diastolic peak velocities ratio. ResultsCompared with controls, patients with AAA had higher baseline LAD peak diastolic coronary flow velocities (28.3 +/- 5.8 vs. 25.2 +/- 4.5cm/sec, P=0.01), lower hyperemic LAD flow velocities (54.0 +/- 10.3 vs. 57.2 +/- 12.7cm/sec, P=0.220), and consequently lower CFVR (1.9 +/- 0.3 vs. 2.3 +/- 0.5, P<0.001). Multivariate linear regression analysis showed that CFVR was independently associated only with aortic systolic diameter (AoSD) (=-0.679, P=<0.001). ConclusionsOur study demonstrates that noninvasive CFVR is significantly reduced in patients with AAA and AoSD is the most important determinant of impaired CFVR.en_US
dc.identifier.doi10.1111/echo.12782
dc.identifier.endpage982en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue6en_US
dc.identifier.pmid25287024
dc.identifier.scopus2-s2.0-84930374286
dc.identifier.scopusqualityQ3
dc.identifier.startpage975en_US
dc.identifier.urihttps://doi.org/10.1111/echo.12782
dc.identifier.urihttps://hdl.handle.net/11468/17526
dc.identifier.volume32en_US
dc.identifier.wosWOS:000355743600012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Flow Reserveen_US
dc.subjectAscending Aorta Aneurysmen_US
dc.subjectEchocardiographyen_US
dc.titleCoronary Flow Velocity Reserve in Patients with Ascending Aorta Aneurysmen_US
dc.titleCoronary Flow Velocity Reserve in Patients with Ascending Aorta Aneurysm
dc.typeArticleen_US

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