The effects of nitric oxide on the expression of cell adhesion molecules (ICAM-1, UEA-1, and tenascin) in rats with unilateral testicular torsion

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dc.contributor.authorOzturk, H
dc.contributor.authorBuyukbayram, H
dc.contributor.authorOzdemir, E
dc.contributor.authorKetani, A
dc.contributor.authorGurel, A
dc.contributor.authorOnen, A
dc.contributor.authorOtçu, S
dc.date.accessioned2024-04-24T16:18:40Z
dc.date.available2024-04-24T16:18:40Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Purpose: The aim of this study was to determine the effects of nitric oxide (NO) on the expression of adhesion molecules in the early course of testicular I-R injury in rats. Methods: Forty male Sprague-Dawley rats were separated into 4 groups, each containing 10 rats. A sham operation was performed in group 1 (control). In group 2 (I-R), after 6 hours of unilateral testicular torsion, 1 -hour detorsion of the testis was performed. In group 3 (I-R/L-NAME), after performing the same surgical procedures as in group 11, L-NAME was given for 30 minutes. In group 4 (I-R/Mol), after performing the same surgical procedure (torsion and detorsion) as in group 11, molsidomine, an NO donor, was infused for 30 minutes. Then, ipsilateral orchiectomies were performed to measure the tissue levels of malondialdehyde (MDA) and NO and to make histologic examination. Results: MDA values and the testicular injury score decreased and NO values increased in the I-R/Mol-treated group compared with other experimental groups. The tenascin expression in the interstitial space and basement membrane of the tubuli seminiferi were milder in the I-R/Mol group compared with that of the I-R and the I-R/L-NAME. The acrosomes of the spermatids in I-R and I-R/L-NAME groups were stained mildly by lectin. In the I-R and I-R/L-NAME groups, the interstitial spaces, basement membrane of the tubuli seminiferi, and sertoli and germinal cells in testicular tissue were stained intensely by ICAM-1. Conclusions: The expression of adhesion molecules such as tenascin, lectin, and ICAM-1 in the totted testicular tissue may be a pathophysiologic sign of inflammation. NO regulates adhesion molecules expression.en_US
dc.identifier.doi10.1016/S0022-3468(03)00573-6
dc.identifier.endpage1627en_US
dc.identifier.issn0022-3468
dc.identifier.issue11en_US
dc.identifier.pmid14614712
dc.identifier.scopus2-s2.0-0242693201
dc.identifier.scopusqualityQ1
dc.identifier.startpage1621en_US
dc.identifier.urihttps://doi.org/10.1016/S0022-3468(03)00573-6
dc.identifier.urihttps://hdl.handle.net/11468/16226
dc.identifier.volume38en_US
dc.identifier.wosWOS:000186565200012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Coen_US
dc.relation.ispartofJournal of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular Torsionen_US
dc.subjectNitric Oxideen_US
dc.subjectL-Nameen_US
dc.subjectAdhesion Moleculesen_US
dc.subjectRaten_US
dc.titleThe effects of nitric oxide on the expression of cell adhesion molecules (ICAM-1, UEA-1, and tenascin) in rats with unilateral testicular torsionen_US
dc.titleThe effects of nitric oxide on the expression of cell adhesion molecules (ICAM-1, UEA-1, and tenascin) in rats with unilateral testicular torsion
dc.typeArticleen_US

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