The value of micro-ELISA test in the diagnosis of Fasciola hepatica infection

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dc.contributor.authorKaya, Muhsin
dc.contributor.authorBeştaş, Remzi
dc.contributor.authorÇiçek, Muttalip
dc.contributor.authorÖnder, Akın
dc.contributor.authorKaplan, Mehmet Ali
dc.date.accessioned2024-04-24T17:58:22Z
dc.date.available2024-04-24T17:58:22Z
dc.date.issued2013
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı en_US
dc.description.abstractIn sero-diagnosis of parasitic infection, it is essential to inspect cross-reactivity between the target parasite and other parasites in order to assess diagnostic performance. The aim of this study was to determine the cut-off value of antibody titer for diagnosis of F. hepatica (FH) infection by using the micro-ELISA and diagnostic performance of this test. The study population consisted of the following groups: FH group (n=42), Echinococcus granulosus (EG) group (n=27) and control group (n=33). The micro-ELISA test for detection of anti-F. hepatica antibody was performed in all groups. The test was positive in all patients with FH, in 3 out of 27 (11%) patients with EG and in none of the control group. Mean antibody titer was significantly higher in the FH group compared to the EG group (23.8 ± 0.9 DU vs. 5.7 ± 1.2 DU; p < 0.001) and compared to the control group (23.8 ± 0.9 DU vs. 2.4 ± 0.2 DU; p < 0.001). When we used 11,5 DU as a cut-off value for sero-diagnosis of FH, the positive predictive value was 93.3%, negative predictive value was 100%, sensitivity was 100%, and specificity was 95%. Cross-reactions are an important issue in serological diagnosis of parasitic infections. The micro-ELISA test for FH antibody can not definitely discriminate fascioliasis from hydatid disease.en_US
dc.identifier.citationKaya, M., Beştaş, R., Çiçek, M., Önder. ve Kaplan, M. A. (2013). The value of micro-ELISA test in the diagnosis of Fasciola hepatica infection. Türkiye parazitoloji dergisi, 37(1), 23-27.
dc.identifier.doi10.5152/tpd.2013.06
dc.identifier.endpage27en_US
dc.identifier.issn1300-6320
dc.identifier.issue1en_US
dc.identifier.pmid23619041
dc.identifier.scopus2-s2.0-84886848087
dc.identifier.scopusqualityQ3
dc.identifier.startpage23en_US
dc.identifier.trdizinidhttps://search.trdizin.gov.tr/tr/yayin/detay/351738
dc.identifier.urihttps://doi.org/10.5152/tpd.2013.06
dc.identifier.urihttps://hdl.handle.net/11468/23867
dc.identifier.volume37en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofTürkiye parazitoloji dergisi / Türkiye Parazitoloji Derneği = Acta parasitologica Turcica / Turkish Society for Parasitology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe value of micro-ELISA test in the diagnosis of Fasciola hepatica infectionen_US
dc.title
dc.typeArticleen_US

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