Are polysulfone dialyzers stimulating cytokines in hemodialyzed patients with hepatitis C?

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dc.contributor.authorYilmaz, ME
dc.contributor.authorKara, IH
dc.contributor.authorSari, Y
dc.date.accessioned2024-04-24T17:33:15Z
dc.date.available2024-04-24T17:33:15Z
dc.date.issued2001
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study was to determine serum cytokine levels in hemodialyzed patients and healthy controls, and also to investigate the relationship among circulating cytokine and liver enzyme levels reflecting inflammation of the liver in hepatitis C virus (HCV) infection. The present study included 35 patients without HCV and 30 patients with HCV undergoing hemodialysis (HD) at the HD Center of Dicle University in Turkey, and 20 healthy individuals who served as controls. The levels of serum interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and soluble interleukin receptor-2 (sIL-2R) were measured. In patients undergoing HD, serum cytokine levels were measured before and after the treatment. Our observation that TNF-alpha levels are hyperexpressed in chronic renal failure patients with chronic HCV infection suggests a mechanism of inflammation in the liver. In contrast to past studies about cuprophane or hemophan dialyzers, the present study shows that polysulfone dialyzers did not specifically influence levels of TNF-alpha, IL-1 beta, IL-6, or IL-8. Serum sIL-2R levels were significantly increased after HD with polysulfone dialyzers in both groups of hemodialyzed patients.en_US
dc.identifier.endpage+en_US
dc.identifier.issn0090-2934
dc.identifier.issn1932-6920
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-0035009887
dc.identifier.scopusqualityN/A
dc.identifier.startpage288en_US
dc.identifier.urihttps://hdl.handle.net/11468/20564
dc.identifier.volume30en_US
dc.identifier.wosWOS:000168435800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDialysis & Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleAre polysulfone dialyzers stimulating cytokines in hemodialyzed patients with hepatitis C?en_US
dc.titleAre polysulfone dialyzers stimulating cytokines in hemodialyzed patients with hepatitis C?
dc.typeArticleen_US

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