Are polysulfone dialyzers stimulating cytokines in hemodialyzed patients with hepatitis C?
[ X ]
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The purpose of this study was to determine serum cytokine levels in hemodialyzed patients and healthy controls, and also to investigate the relationship among circulating cytokine and liver enzyme levels reflecting inflammation of the liver in hepatitis C virus (HCV) infection. The present study included 35 patients without HCV and 30 patients with HCV undergoing hemodialysis (HD) at the HD Center of Dicle University in Turkey, and 20 healthy individuals who served as controls. The levels of serum interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and soluble interleukin receptor-2 (sIL-2R) were measured. In patients undergoing HD, serum cytokine levels were measured before and after the treatment. Our observation that TNF-alpha levels are hyperexpressed in chronic renal failure patients with chronic HCV infection suggests a mechanism of inflammation in the liver. In contrast to past studies about cuprophane or hemophan dialyzers, the present study shows that polysulfone dialyzers did not specifically influence levels of TNF-alpha, IL-1 beta, IL-6, or IL-8. Serum sIL-2R levels were significantly increased after HD with polysulfone dialyzers in both groups of hemodialyzed patients.
Açıklama
Anahtar Kelimeler
[No Keyword]
Kaynak
Dialysis & Transplantation
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
30
Sayı
5
