The role of enzymatic antioxidant defense system and lipid peroxidation on gentamicin nephrotoxicity in rat renal tissues

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dc.contributor.authorIsik, FB
dc.contributor.authorErdinc, L
dc.contributor.authorMete, N
dc.contributor.authorErdinc, M
dc.contributor.authorKetani, MA
dc.contributor.authorYokus, B
dc.date.accessioned2024-04-24T17:39:58Z
dc.date.available2024-04-24T17:39:58Z
dc.date.issued1998
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe activities of antioxidant enzymes, superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and catalase (CAT), and the levels of malondialdehyde (MDA), an end product of lipid peroxidation, in kidney tissues were measured in rats treated with gentamicin alone (100 mg/kg/day subcutaneously (s.c.)) for 10 days or gentamicin together with vitamin E (300 mg/kg/day intraperitoneally (i.p)) for 10 days. Gentamicin caused depression in activities of the antioxidant enzymes (SOD, GSH-Px, CAT)) and elevation in MDA levels. These effects were highly significant when compared to the effects of placebo in control group (P < 0.001). Vitamin E was found to be ineffective for preventing gentamicin induced nephrotoxicity as determined both functionally and histopathologically. Although there was a borderline decrease of MDA levels (p < 0.05) in rats taking vitamin E, there was no difference in the activities of antioxidant enzymes between the rats taking gentamicin with or without vitamin E. Our finding suggests that gentamicin nephrotoxicity causes a decrease in the activities of antioxidant enzymes and an increase in the level of lipid peroxidation, and vitamin E do not has any preventive effect against gentamicin nephrotoxicity.en_US
dc.identifier.endpage186en_US
dc.identifier.issn0749-5331
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0031706493
dc.identifier.scopusqualityN/A
dc.identifier.startpage177en_US
dc.identifier.urihttps://hdl.handle.net/11468/21477
dc.identifier.volume14en_US
dc.identifier.wosWOS:000075515200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherMbr Press Incen_US
dc.relation.ispartofBiochemical Archives
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGentamicinen_US
dc.subjectNephrotoxicityen_US
dc.subjectLipid Peroxidationen_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectCatalaseen_US
dc.titleThe role of enzymatic antioxidant defense system and lipid peroxidation on gentamicin nephrotoxicity in rat renal tissuesen_US
dc.titleThe role of enzymatic antioxidant defense system and lipid peroxidation on gentamicin nephrotoxicity in rat renal tissues
dc.typeArticleen_US

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