The role of enzymatic antioxidant defense system and lipid peroxidation on gentamicin nephrotoxicity in rat renal tissues
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Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mbr Press Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The activities of antioxidant enzymes, superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and catalase (CAT), and the levels of malondialdehyde (MDA), an end product of lipid peroxidation, in kidney tissues were measured in rats treated with gentamicin alone (100 mg/kg/day subcutaneously (s.c.)) for 10 days or gentamicin together with vitamin E (300 mg/kg/day intraperitoneally (i.p)) for 10 days. Gentamicin caused depression in activities of the antioxidant enzymes (SOD, GSH-Px, CAT)) and elevation in MDA levels. These effects were highly significant when compared to the effects of placebo in control group (P < 0.001). Vitamin E was found to be ineffective for preventing gentamicin induced nephrotoxicity as determined both functionally and histopathologically. Although there was a borderline decrease of MDA levels (p < 0.05) in rats taking vitamin E, there was no difference in the activities of antioxidant enzymes between the rats taking gentamicin with or without vitamin E. Our finding suggests that gentamicin nephrotoxicity causes a decrease in the activities of antioxidant enzymes and an increase in the level of lipid peroxidation, and vitamin E do not has any preventive effect against gentamicin nephrotoxicity.
Açıklama
Anahtar Kelimeler
Gentamicin, Nephrotoxicity, Lipid Peroxidation, Superoxide Dismutase, Glutathione Peroxidase, Catalase
Kaynak
Biochemical Archives
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
14
Sayı
3
