The effect of dexamethasone on gastric mucosal changes following sialoadenectomy in rat

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dc.contributor.authorElitok, B
dc.contributor.authorElitok, ÖM
dc.contributor.authorKetani, MA
dc.contributor.authorKurt, D
dc.contributor.authorKanay, Z
dc.date.accessioned2024-04-24T15:59:41Z
dc.date.available2024-04-24T15:59:41Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, dexamethasone-induced gastric lesions were studied in rats that had undergone sialoadenectomy. The ultrastructural changes developed during the study were detected by electron microscopically, while blood serum and stomach epidermal growth factor (EGF) concentrations were measured by RIA. The result of the study showed that gastric lesions were correlated with gastric mucus secretion and both serum and mucosa EGF levels. After the administration of dexamethasone, it was found that sialoadenectomy significantly (p < 0.01) raised the incidence of stomach lesions (p < 0.01), and a significant increase in mucus secretion was also found. Additionally, the serum and gastric mucosal EGF levels fell after sialoadenectomy when compared to normal rats. The most important gastric mucosal changes were observed in rats treated with dexamethasone and those both sialoadenectomised and treated with clexamethasone.en_US
dc.identifier.doi10.1007/BF03347552
dc.identifier.endpage703en_US
dc.identifier.issn0391-4097
dc.identifier.issue8en_US
dc.identifier.pmid16277165
dc.identifier.scopus2-s2.0-31544434518
dc.identifier.scopusqualityQ1
dc.identifier.startpage700en_US
dc.identifier.urihttps://doi.org/10.1007/BF03347552
dc.identifier.urihttps://hdl.handle.net/11468/14212
dc.identifier.volume28en_US
dc.identifier.wosWOS:000232814300004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSialoadenectomyen_US
dc.subjectRaten_US
dc.subjectElectron Microscopyen_US
dc.subjectDexamethasoneen_US
dc.titleThe effect of dexamethasone on gastric mucosal changes following sialoadenectomy in raten_US
dc.titleThe effect of dexamethasone on gastric mucosal changes following sialoadenectomy in rat
dc.typeArticleen_US

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