Evaluation of Hepatitis B Viraemia Levels in Patients with HBeAg-negative Chronic Hepatitis B Virus Infection

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dc.contributor.authorAtay, A. E.
dc.contributor.authorSeven, G.
dc.contributor.authorYalcin, K.
dc.contributor.authorPasa, S.
dc.contributor.authorDegertekin, H.
dc.date.accessioned2024-04-24T17:14:34Z
dc.date.available2024-04-24T17:14:34Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVES: To evaluate patients with chronic hepatitis B virus (HBV) infection and low-level viraemia in terms of determining HBV DNA cut-off values and levels of alanine aminotransferase (ALT) and other possible markers for discriminating between chronic hepatitis B e-antigen (HBeAg)-negative patients and hepatitis B surface antigen (HBsAg) inactive carriers. METHODS: HBV-infected patients who were HBeAg-negative with undetectable HBV DNA by standard hybridization assay and high (HBeAg-negative group, n = 81) or normal (HBsAg inactive carrier group, n = 77) ALT levels were enrolled. Quantitative polymerase chain reaction assay using a COBAS Amplicor HBV monitor test was performed to detect low HBV DNA levels. RESULTS: The HBV DNA level was found to be significantly higher in the HBeAg-negative chronic HBV group (mean +/- SD 94 477 +/- 167 528 copies/nil) compared with the HBsAg inactive carrier group (mean +/- SD 19 215 +/- 57 970 copies/ml). CONCLUSIONS: A low level of viral replication may persist in chronic HBV-infected patients who are HBeAg-negative, and the level of HBV DNA was higher in the HBeAg-negative group than in the inactive HBsAg carrier group. Necroinflammation also persisted in the HBeAg-negative group and these patients had a higher level of ALT than the inactive HBsAg carriers.en_US
dc.identifier.doi10.1177/030006051204000529
dc.identifier.endpage1896en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue5en_US
dc.identifier.pmid23206472
dc.identifier.scopus2-s2.0-84880644661
dc.identifier.scopusqualityQ2
dc.identifier.startpage1891en_US
dc.identifier.urihttps://doi.org/10.1177/030006051204000529
dc.identifier.urihttps://hdl.handle.net/11468/18063
dc.identifier.volume40en_US
dc.identifier.wosWOS:000311762200029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHbeag-Negative Chronic Hepatitis Ben_US
dc.subjectInactive Carriersen_US
dc.subjectHepatitis B Virus (Hbv)en_US
dc.subjectHbv Dna Levelen_US
dc.titleEvaluation of Hepatitis B Viraemia Levels in Patients with HBeAg-negative Chronic Hepatitis B Virus Infectionen_US
dc.titleEvaluation of Hepatitis B Viraemia Levels in Patients with HBeAg-negative Chronic Hepatitis B Virus Infection
dc.typeArticleen_US

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