Honokiol Decreases intra-Abdominal Adhesion Formation in a Rat Model

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dc.contributor.authorAgacayak, Elif
dc.contributor.authorTunc, Senem Yaman
dc.contributor.authorIcen, Mehmet Sait
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorFindik, Fatih Mehmet
dc.contributor.authorYuksel, Hatice
dc.contributor.authorGul, Talip
dc.date.accessioned2024-04-24T17:14:29Z
dc.date.available2024-04-24T17:14:29Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to investigate the effectiveness of honokiol, a natural molecule that was shown to have antioxidant effects, in prevention of intra-abdominal adhesion formation in a rat model. Material and Method: This study was conducted on a total of 40 non-pregnant Sprague-Dawley rats, which were divided into 4 groups as follows: sham, control, saline, and honokiol groups. Both uterine horns of the rats in control, saline, and honokiol groups were exposed and a 2-cm segment of the anti-mesenteric surface of both uterine horns was traumatized by a scalpel. The saline group was administered 2 ml of saline/day intraperitoneally for 5 days after the operation. The honokiol group, on the other hand, was administered honokiol intraperitoneally at a dose of 1 mg/kg/day for 5 days after the operation. On postoperative day 14, 3 ml of intracardiac blood sample was taken from the rats for biochemical analyses, and the rats were sacrificed this way. Results: Adhesion and inflammation scores were significantly lower in the honokiol group compared with the saline and control groups (p < 0.008). Similarly, fibrosis score was significantly lower in the honokiol group compared with the saline group (p < 0.008). Conclusion: Honokiol was found to be effective in prevention of intra-abdominal adhesion formation in a rat model. However, larger studies are needed to shed light on the exact role of honokiol in intra-abdominal adhesion formation and to determine the molecular aspects of the promising results found in this study. (C) 2015 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000367661
dc.identifier.endpage167en_US
dc.identifier.issn0378-7346
dc.identifier.issn1423-002X
dc.identifier.issue3en_US
dc.identifier.pmid25632973
dc.identifier.scopus2-s2.0-84926421663
dc.identifier.scopusqualityQ2
dc.identifier.startpage160en_US
dc.identifier.urihttps://doi.org/10.1159/000367661
dc.identifier.urihttps://hdl.handle.net/11468/17982
dc.identifier.volume79en_US
dc.identifier.wosWOS:000353011100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic and Obstetric Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHonokiolen_US
dc.subjectIntra-Abdominal Adhesionsen_US
dc.subjectRaten_US
dc.titleHonokiol Decreases intra-Abdominal Adhesion Formation in a Rat Modelen_US
dc.titleHonokiol Decreases intra-Abdominal Adhesion Formation in a Rat Model
dc.typeArticleen_US

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