Tuberculous meningitis in adults: an eleven-year review

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dc.contributor.authorHosoglu, S
dc.contributor.authorAyaz, C
dc.contributor.authorGeyik, MF
dc.contributor.authorKokoglu, OF
dc.contributor.authorCeviz, A
dc.date.accessioned2024-04-24T17:39:59Z
dc.date.available2024-04-24T17:39:59Z
dc.date.issued1998
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To assess the presentation, diagnosis and outcome of patients with tuberculous meningitis (TBM). DESIGN: The medical records of adults with TBM who were treated at Dicle University Hospital between January 1985 and October 1996 were reviewed. RESULTS: In total, 101 patients were identified and stratified according to the stage of disease at presentation. The mean duration of the symptoms of TBM before admission was 12 days. The majority of patients had headaches (96.0%), fever (91.1%), nuchal rigidity (91.1%), vomiting (81.2%), meningism (79.2%) and abnormal mental state (72.3%). The mean cerebrospinal fluid (CSF) leukocyte count was 0.38 x 10(9)/L, protein 1410 mg/L, glucose 2.0 mmol/L and CSF/blood glucose ratio 27%. Cranial computerized tomography (CT) scans were performed during the course of TBM in 64 patients. The results were normal in 6.3%, and abnormal in 93.7% of the cases; the most frequent abnormality found on CT was hydrocephalus (45.3%). Forty-four patients (43.5%) died. Minor neurological sequelae developed in 11 patients (10.9%), major sequelae in 10 (9.9%), and 31 patients (30.7%) completely recovered. There was no follow-up for five patients (5.0%). Five factors were important in predicting fatal outcome: stage III at presentation, low glucose levels, low CSF/blood glucose ratio, high protein levels, and CT scanning abnormality. CONCLUSION: TBM is a very critical disease in terms of fatal outcome and permanent sequelae: 43.5% of the patients died and only 30.7% experienced complete recovery. Early treatment may reduce fatal outcome and morbidity.en_US
dc.identifier.endpage557en_US
dc.identifier.issn1027-3719
dc.identifier.issue7en_US
dc.identifier.pmid9661821
dc.identifier.scopus2-s2.0-0031851552
dc.identifier.scopusqualityQ2
dc.identifier.startpage553en_US
dc.identifier.urihttps://hdl.handle.net/11468/21506
dc.identifier.volume2en_US
dc.identifier.wosWOS:000074539600005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt Union Against Tuberculosis Lung Disease (I U A T L D)en_US
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTuberculous Meningitisen_US
dc.subjectAdultsen_US
dc.subjectClinical Courseen_US
dc.subjectFatal Outcome Factorsen_US
dc.titleTuberculous meningitis in adults: an eleven-year reviewen_US
dc.titleTuberculous meningitis in adults: an eleven-year review
dc.typeArticleen_US

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