Familial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide network

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dc.contributor.authorYurdakul, Fatma Gül
dc.contributor.authorBodur, Hatice
dc.contributor.authorÇay, Hasan Fatih
dc.contributor.authorUçar, Ülkü
dc.contributor.authorKeskin, Yaşar
dc.contributor.authorSargın, Betül
dc.contributor.authorGürer, Gülcan
dc.date.accessioned2024-04-24T16:00:06Z
dc.date.available2024-04-24T16:00:06Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to analyze the pregnancy process, especially the Familial Mediterranean fever (FMF) disease course and attack types during pregnancy, and to examine the relationship between disease-related factors and female infertility in FMF patients. The study, which was planned in a multicenter national network, included 643 female patients. 435 female patients who had regular sexual intercourse were questioned in terms of infertility. Pregnancy and delivery history, FMF disease severity and course during pregnancy were evaluated. The relationship between demographic and clinical findings, disease severity, genetic analysis results and infertility was investigated. 401 patients had at least 1 pregnancy and 34 patients were diagnosed with infertility. 154 patients had an attack during pregnancy. 61.6% of them reported that attacks during pregnancy were similar to those when they were not pregnant. The most common attack symptoms were fever, fatigue and abdominal pain-peritonitis (96%, 87%, and 83%, respectively) in the pregnancy period. The disease-onset age, disease activity score, gene mutation analyses, and regular colchicine use (> 90%) were similar between the fertile and infertile groups, while the frequency of previous appendectomy and alcohol consumption rates were higher in individuals with infertility. Our results indicated no significant change in the frequency and severity of attacks during pregnancy. The low rate of infertility (7.8%) in our patients was noted. It has been suggested that the risk of FMF-related infertility may not be as high as thought in patients who are followed up regularly and received colchicine.en_US
dc.identifier.citationYurdakul, F. G., Bodur, H., Çay, H. F., Uçar, Ü., Keskin, Y., Sargın, B. ve diğerleri. (2023). Familial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide network. Rheumatology International, 1-11
dc.identifier.doi10.1007/s00296-023-05436-w
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.pmid37658927
dc.identifier.scopus2-s2.0-85169311793
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00296-023-05436-w
dc.identifier.urihttps://hdl.handle.net/11468/14374
dc.identifier.wosWOS:001061769900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfertilityen_US
dc.subjectPregnancyen_US
dc.subjectAmyloidosisen_US
dc.subjectSerositisen_US
dc.subjectColchicineen_US
dc.titleFamilial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide networken_US
dc.titleFamilial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide network
dc.typeArticleen_US

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