Impact of N-acetylcysteine and Etodolac Treatment on Systolic and Diastolic Function in a Rat Model of Myocardial Steatosis Induced by High-Fat-Diet

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dc.contributor.authorTopal, Askin Ender
dc.contributor.authorAkkoc, Hasan
dc.contributor.authorKelle, Ilker
dc.contributor.authorYilmaz, Sedat
dc.contributor.authorTopal, Derya
dc.contributor.authorAkkus, Murat
dc.date.accessioned2024-04-24T17:18:35Z
dc.date.available2024-04-24T17:18:35Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: Obesity is a worldwide problem, leading to cardiomyopathy. Oxidative stress and inflammation have been reported to play significant roles in developing obesity cardiomyopathy. N-acetylcysteine is a glutathione prodrug that preserves liver against steatosis via constraining the production of reactive oxygen species. Etodolac is a nonsteroidal anti-inflammatory drug which has been demonstrated to protect liver against fibrosis. The aim of the present study was to evaluate and compare the effects of N-acetylcysteine and etodolac on impaired cardiac functions due to high-fat-diet (HFD) induced myocardial steatosis in rats. Material and Methods: Thirty-two male Sprague-Dawley rats were randomly divided into four groups. Control group was maintained on standard-rat-basic-diet (SD) for 20 weeks, while HFD was given to three study groups for 20 weeks. Then N-acetylcysteine was given to one of the study groups (HFD+NAC), and etodolac to another group (HFD+ETD) as a supplement for 4 weeks while all groups were continued on SD. At the end of the study periods, hearts were examined by Langendorff technique and rat livers were evaluated histologically. Results: HFD and HFD+ETD groups presented with significantly higher steatosis and fibrosis in liver compared to other groups. HFD+NAC preserved diastolic functions. Also HFD+NAC and HFD+ETD groups had significantly better systolic funtions than HFD group. Conclusions: Obesity is associated with diastolic dysfunction rather than systolic dysfunction. NAC may protect the heart against diastolic dysfunction due to obesity. NAC and etodolac treatment improve systolic function, even in the absence of systolic dysfunction.en_US
dc.identifier.doi10.2174/1871530314666141028144702
dc.identifier.endpage319en_US
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue4en_US
dc.identifier.pmid25348332
dc.identifier.scopus2-s2.0-84924284787
dc.identifier.scopusqualityQ2
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.2174/1871530314666141028144702
dc.identifier.urihttps://hdl.handle.net/11468/18837
dc.identifier.volume14en_US
dc.identifier.wosWOS:000348651300011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiastolic Dysfunctionen_US
dc.subjectEtodolacen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectObesityen_US
dc.subjectSteatosisen_US
dc.subjectSystolic Dysfunctionen_US
dc.titleImpact of N-acetylcysteine and Etodolac Treatment on Systolic and Diastolic Function in a Rat Model of Myocardial Steatosis Induced by High-Fat-Dieten_US
dc.titleImpact of N-acetylcysteine and Etodolac Treatment on Systolic and Diastolic Function in a Rat Model of Myocardial Steatosis Induced by High-Fat-Diet
dc.typeArticleen_US

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