Epidemiology and risk factors for ESBL-producing Klebsiella pneumoniae: a case control study

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dc.contributor.authorDemirdag, Kutbettin
dc.contributor.authorHosoglu, Salih
dc.date.accessioned2024-04-24T17:20:59Z
dc.date.available2024-04-24T17:20:59Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: Increased production of extended-spectrum beta-lactamases (ESBLs) has become an important issue for treatment of severe Klebsiella pneumoniae (K. pneumoniae) infections. This study aimed to evaluate risk factors of infection from ESBL-producing K. pneumoniae (ESBL-KP). Methodology: Risk factors were evaluated using a retrospective case control design. Fifty-two patients admitted to Firat University Hospital (FUH) with invasive infections from ESBL-KP were employed as cases. Patients admitted to FUH with non-ESBL-producing K. pneumoniae invasive infection were chosen as controls. Potential risk factors of the cases and controls were evaluated using hospital charts. Pulsed-field Gel Electrophoresis (PFGE) was used to show the relatedness of ESBL-KP strains. Results: In univariate analysis, the following factors were found significant for ESBL-KP: pre-infection hospital stay, nosocomial origin, central venous catheterization, surgical intervention, antibiotic use longer than one week, and previous hospitalization. In contrast, stepwise logistic regression analysis showed that two variables, previous antibiotic use (p = 0.000) and surgical intervention (p = 0.006), remained significantly associated with risk for infection with an ESBL-KP. Molecular epidemiology identified several clusters among the ESBL-producing isolates. Conclusions: Antibiotic use and surgical intervention were significant associated factors for infections with ESBL-KP.en_US
dc.identifier.doi10.3855/jidc.778
dc.identifier.endpage722en_US
dc.identifier.issn1972-2680
dc.identifier.issue11en_US
dc.identifier.pmid21252449
dc.identifier.scopus2-s2.0-78650387029
dc.identifier.scopusqualityQ2
dc.identifier.startpage717en_US
dc.identifier.urihttps://doi.org/10.3855/jidc.778
dc.identifier.urihttps://hdl.handle.net/11468/19330
dc.identifier.volume4en_US
dc.identifier.wosWOS:000208252800006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJ Infection Developing Countriesen_US
dc.relation.ispartofJournal of Infection in Developing Countries
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEsblen_US
dc.subjectEpidemiologyen_US
dc.subjectRisk Factorsen_US
dc.subjectCase Control Studyen_US
dc.subjectPfge Typingen_US
dc.titleEpidemiology and risk factors for ESBL-producing Klebsiella pneumoniae: a case control studyen_US
dc.titleEpidemiology and risk factors for ESBL-producing Klebsiella pneumoniae: a case control study
dc.typeArticleen_US

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