Comparison of clinical, hormonal, pathological and treatment outcomes of ectopic Cushing's syndrome by sex: results of a multicenter study

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dc.authoridGokcay Canpolat, Asena/0000-0003-1186-2960
dc.authoridGul, Nurdan/0000-0002-1187-944X
dc.contributor.authorCiftci, Sema
dc.contributor.authorYilmaz, Nusret
dc.contributor.authorSelcukbiricik, Ozlem Soyluk
dc.contributor.authorHekimsoy, Zeliha
dc.contributor.authorCanpolat, Asena Goekcay
dc.contributor.authorTopsakal, Senay
dc.contributor.authorYaylali, Guzin Fidan
dc.date.accessioned2025-02-22T14:09:04Z
dc.date.available2025-02-22T14:09:04Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To compare clinical and hormonal data, neuroendocrine neoplasia (NEN) localization, treatment, and survival outcomes in ectopic Cushing's syndrome (ECS) by sex. Methods: Eleven experienced centers from our country participated in this retrospective study. The clinical and hormonal features, tumor imaging, pathological results, treatment modalities, and disease courses of the patients were evaluated. Results: 28 female and 26 male patients with ECS were compared. The mean age at diagnosis, clinical characteristics, and hormonal evaluation results were similar. However, insulin-requiring diabetes mellitus (p = 0.04) and osteoporosis with fractures were more common in males (p = 0.03). While more patients with increased DHEA-S levels than the upper limit of normal were found to be higher in females, central hypothyroidism were higher in males (p = 0.02). At the diagnosis, 36 NENs (68% of females and 69% of males) were localized. Small cell lung carcinoma was higher in males (p = 0.02), and the frequency of other NENs was not different. Curative surgery was performed on 61% of females and 46% of males. Tumor size, Ki-67 labeling index, positive ACTH immunostaining, local lymph node and distant metastasis rates were similar in both sexes. In the follow-up, the tumor became visible in 7 of 10 females and 4 of 8 males after medical treatment and/or bilateral adrenalectomy. The remission rates (65% of females, 62% of males) and NEN-related death rates (14% of females, 30% of males) were similar. Conclusion: While ECS has a similar disease course in many aspects in males and females, hyperglycemia and osteoporosis are more severe in males.en_US
dc.identifier.doi10.1007/s12020-024-04004-x
dc.identifier.endpage1155en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue3en_US
dc.identifier.pmid39287756en_US
dc.identifier.scopus2-s2.0-85204281698en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1148en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-024-04004-x
dc.identifier.urihttps://hdl.handle.net/11468/29782
dc.identifier.volume86en_US
dc.identifier.wosWOS:001314814300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectEctopic ACTH syndromeen_US
dc.subjectCushing's syndromeen_US
dc.subjectSex differenceen_US
dc.subjectNeuroendocrine tumoren_US
dc.subjectNeuroendocrine neoplasiaen_US
dc.titleComparison of clinical, hormonal, pathological and treatment outcomes of ectopic Cushing's syndrome by sex: results of a multicenter studyen_US
dc.typeArticleen_US

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