Effects of gabexate mesilate on ischemia-reperfusion-induced testicular injury in rats

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dc.contributor.authorGezici, A
dc.contributor.authorOzturk, H
dc.contributor.authorBuyukbayram, H
dc.contributor.authorOzturk, H
dc.contributor.authorOkur, H
dc.date.accessioned2024-04-24T16:00:11Z
dc.date.available2024-04-24T16:00:11Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effects of a synthetic serine protease inhibitor, gabexate mesilate (GM), in rats with ischemia-reperfusion (I-R) damage due to unilateral testicular torsion. Thirty male Sprague-Dawley rats were separated into three groups, each containing ten rats. A sham operation was performed in group 1 (control). In group 2 (I-R/untreated), 1 h detorsion of the testis was performed after 6 h of unilateral testicular torsion. In group 3 (I-R/GM), after performing the same surgical procedures as in group II, gabexate mesilate was given intravenously. In all experimental rats, ipsilateral orchiectomies were performed for histological examination and measuring the tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). MDA values and the testicular injury score decreased and SOD, CAT and GSH-Px values increased in the GM-treated group compared to the I-R/untreated group. The Tc-99m pertechnetate uptake ratio and the perfusion index were significantly decreased in the group 2 compared to the group 1 and 3 rats. In group 3, these values were significantly increased compared to group 2. Most of the specimens in the GM-treated group showed grade-I testicular injury. However, the injuries in the I-R/untreated rats varied between grade-III and grade-IV. The results of this study show that GM may play a role in reducing the injury caused by I-R.en_US
dc.identifier.doi10.1007/s00383-006-1667-y
dc.identifier.endpage441en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue5en_US
dc.identifier.pmid16557390
dc.identifier.scopus2-s2.0-33646444286
dc.identifier.scopusqualityQ2
dc.identifier.startpage435en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-006-1667-y
dc.identifier.urihttps://hdl.handle.net/11468/14399
dc.identifier.volume22en_US
dc.identifier.wosWOS:000237192700008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular Torsionen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectGabexate Mesilateen_US
dc.subjectRaten_US
dc.titleEffects of gabexate mesilate on ischemia-reperfusion-induced testicular injury in ratsen_US
dc.titleEffects of gabexate mesilate on ischemia-reperfusion-induced testicular injury in rats
dc.typeArticleen_US

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