Bone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis?

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dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0001-9680-6268en_US
dc.authorid0000-0002-8390-5109en_US
dc.authorid0000-0002-5845-0851en_US
dc.contributor.authorGür, Ali
dc.contributor.authorDikici, Bünyamin
dc.contributor.authorNas, Kemal
dc.contributor.authorBoşnak, Mehmet
dc.contributor.authorHaspolat, Yusuf Kenan
dc.contributor.authorSaraç, Ayşe Jale
dc.date.accessioned2021-12-03T11:39:40Z
dc.date.available2021-12-03T11:39:40Z
dc.date.issued2005en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalıen_US
dc.description.abstractBackground: Our aim was to determinate bone mineral density (BMD), levels of biochemical markers and cytokines in children with chronic hepatitis B treated with interferon (IFN)-alpha and to investigate effect of IFN-alpha therapy on these variables. To the best of our knowledge, this is first study carried out about BMD and cytokine levels in pediatric patients with chronic hepatitis B treated with IFN-alpha. Methods: BMD, levels of parathyroid hormone (PTH), osteocalcin, C-terminal cross-linking telopeptide of type I collagen (CTX), calcium, alkaline phosphates (ALP), cytokines as TNF-alpha, interleukin (IL)-1beta, IL-2r, IL-6, and IL-8 were studied in 54 children with chronic hepatitis B (4-15 years old) treated with interferon alone (n = 19) or in combination with lamivudine (n = 35) for six months and as controls in 50 age-matched healthy children. Results: There was no significant difference in respect to serum IL-1beta, TNF-alpha and osteocalcin levels while serum IL-2r (p = 0.002), IL-6 (p = 0.001), IL-8 (p = 0.013), PTH (p = 0.029), and CTX (p = 0.021) levels were higher in children with chronic hepatitis B than in healthy controls. BMD of femur neck (p = 0.012) and trochanter (p = 0.046) in patients were higher than in healthy controls. There was a statistically significant correlation between serum IL-1beta and osteocalcin (r = -0.355, p < 0.01); between serum IL-8 and CTX levels (r = 0.372, p = 0.01), and ALP (r = 0.361, p = 0.01); between serum ALP and femur neck BMD (r = 0.303, p = 0.05), and trochanter BMD (r = 0.365, p = 0.01); between spine BMD and IL-2R (r = -0.330, p < 0.05). Conclusion: In conclusion, our study suggest that BMD of femur, serum IL-2r, IL-6, IL-8, PTH, and CTX levels were higher in children with chronic hepatitis B treated with IFN-alpha alone or combination with lamivudine than in healthy children. High femur BMD measurements found in patients may suggest that IFN-alpha therapy in children with chronic hepatitis B could contribute indirectly to prevent from hip osteoporosis. Additionally, further investigations on effects of IFN-alpha for bone structure in children should be performed in the future.en_US
dc.identifier.citationGür, A., Dikici, B., Nas, K., Boşnak, M., Haspolat, Y. K., Saraç, A. J. ve diğerleri. (2005). Bone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis?. BMC Gastroenterology, 5(30), 1-8.en_US
dc.identifier.doi10.1186/1471-230X-5-30
dc.identifier.endpage8en_US
dc.identifier.issn1471-230X
dc.identifier.issue30en_US
dc.identifier.pmid16171525
dc.identifier.scopus2-s2.0-26444569263
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/16171525/
dc.identifier.urihttps://hdl.handle.net/11468/8352
dc.identifier.volume5en_US
dc.identifier.wosWOS:000232371600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGür, Ali
dc.institutionauthorDikici, Bünyamin
dc.institutionauthorNas, Kemal
dc.institutionauthorBoşnak, Mehmet
dc.institutionauthorHaspolat, Yusuf Kenan
dc.institutionauthorSaraç, Ayşegül Jale
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofBMC Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectHepatitis Ben_US
dc.subjectOsteoporosisen_US
dc.subjectDensityen_US
dc.subjectTherapyen_US
dc.subjectBone mineral densityen_US
dc.titleBone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis?en_US
dc.titleBone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis?
dc.typeArticleen_US

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