DSpace Arşivi :: by Yazar "Yucel, Yavuz" değerine göre listeleniyor

Yazar "Yucel, Yavuz" seçeneğine göre listele

Listeleniyor 1 - 17 / 17

ACUTE TOXIC EFFECTS OF METHYL ALCOHOL ON THE RAT BRAIN: THE PROTECTIVE EFFECTS OF CAFFEIC ACID PHENETHYL ESTER
(Carbone Editore, 2014) Cevik, Mehmet Ugur; Varol, Sefer; Yucel, Yavuz; Akil, Esref; Uzar, E.; Kaplan, I; Can, Yazgan Umit
Background: Efficiency of caffeic acid phenethyl ester (CAPE) in reducing free radicals generated by oxidative stress has been previously reported. In the present study, the protective effect of CAPE on methyl alcohol (MeOH) induced oxidative damages on rat brain were presented. Methods: The rats were randomly divided into four groups as follows: Control, methotrexate (MTX) alone, MTX+MeOH, and MTX+MeOH+CAPE (CAPE treatment). All animals except the control group were treated with MTX for 7 days. MTX was diluted in sterile saline and administered (0.3 mg/kg/day) intraperitoneally (ip). At the eighth day, MeOH was administered (3gm/Kg) (ip) in MeOH+MTX and CAPE treatment groups. Four hours after MeOH administration in the CAPE group rats were treated with 10 mu mol/kg CAPE (ip), serum physiologic (i.p.) in MeOH+MTX group. After eight hours, rats were anaesthetized and sacrificed. Malondialdehyde (MDA) levels, paraoxonase-1 (PON-1) activity were measured on the cerebral tissue. Results: MTX+MeOH group compared to the MTX alone group; a statistically significant increase in MDA levels (p = 0.042) were detected. In addition, MTX+MeOH group than MTX MTX alone group in led to a statistically significant decrease in PON-I activity (p = 0.018). CAPE treatment, significantly decrease in MDA levels was compared with MeOH+MTX (p = 0.001). However, CAPE treatment caused an increase on PON-I activity in MeOH group, which was statistically significant (p = 0.009). Conclusion: Consequently, it was demonstrated for the first time that CAPE prevents acute MeOH intoxication induced brain injury by reducing the increase in lipid peroxidation, and elevating the decrease in PON-1 activity.
Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
(Korean Coll Neuropsychopharmacology, 2016) Yucel, Yavuz; Coskun, Salih; Cengiz, Beyhan; Ozdemir, Hasan H.; Uzar, Ertugrul; Cim, Abdullah; Camkurt, M. Akif
Objective: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5 HT) and their respective receptors have been implicated in the patogenesis. Methods: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. Results: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. Conclusion: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.
Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG and NRIP1 genes to migraine susceptibility in Turkish population
(Indian Acad Sciences, 2016) Coskun, Salih; Yucel, Yavuz; Cim, Abdullah; Cengiz, Beyhan; Oztuzcu, Serdar; Varol, Sefer; Ozdemir, Hasan H.
Migraine, a highly prevalent headache disorder, is regarded as a polygenic multifactorial disease, Single-nucleotide polymorphisms (SNPs) in the genes that involved in sex hormone metabolism may comprise risk for migraine, but the results of previous genetic association studies are conflicting. The aim of this study was to evaluate genetic variants in genes involved in oestrogen receptor and oestrogen hormone metabolism in a Turkish population. A total of 12 SNPs in the ESR1, ESR2. FSHR, CYP19A1 SHBG and NRIP1 genes were genotyped in 142 migraine cases and 141 nonmigraine controls, using a 13iolVtark 96,96 dynamic array system. In addition, gene gene interactions were analysed using generalized multifactor dimensionality reduction (GMDR) methods. According to GI\ADR analysis, our results indicated that there was a significant association between migraine and gene gene interaction a.mong the CYP19A1 FSHR, ESR1 and NRIP1, Single-gene variant analysis showed that a significant association was observed between the TT genotype of rs10046 and migraine susceptibility. When the analysis was performed only in women, the GG genotype of rs222974I was different between migaineurs and controls. When the female migraine patients were divided into two groups, migraine related to menstruation ilVIRM) or migraine not related to menstruation (MN RN), OG genotype of rs726281 was significantly associated with M FM. These results suggested that rs10046 could play a potential role in migyaine susceptibility in Turkish population, Also, the rare GG genotype of rs726281 appears to influence migraine susceptibility in a recessive manner in MRM subgroup of female patients. In addition, variant GG genotype of rs2229741 may reduce the risk of migraine in Turkish women.
Diagnostic value of F-wave inversion in patients with early carpal tunnel syndrome
(Elsevier Ireland Ltd, 2012) Cevik, Mehmet Ugur; Altun, Yasar; Uzar, Ertugrul; Acar, Abdullah; Yucel, Yavuz; Arikanoglu, Adalet; Varol, Sefer
Routine electrophysiological studies usually give normal results in patients with early stage carpal tunnel syndrome (CTS). Diagnostic significance of the F-wave inversion (the median of F-wave minimal latencies (FWML) exceeds a normal ipsilateral ulnar FWML by 1 ms) has not been previously reported in early stage CTS. In this study, our primary aim was to investigate the diagnostic value of F-wave inversion in early stage CTS. Additionally, we aimed to demonstrate any possible relationship between F-wave inversion and symptom scores of the Boston questionnaire and functional capacity in early stage CTS. The study included 60 early stage CTS patients who presented with a median sensory nerve conduction velocity of >= 50 m/s. The symptom severity and functional status of the patients were assessed by using the Boston questionnaire. The control group consisted of 45 healthy volunteers. We compared early stage CTS patients and healthy control subjects in terms of the results obtained from median-ulnar FWML. Existence of F-wave inversion was found in 32 (53.3%) of the early stage CTS patients and in 3 (8.7%) of the healthy controls (p = 0.001). It was also found to be positively correlated with the Boston questionnaire scores (p = 0.001, r = 0.41) and functional capacity scores (p = 0.001, r = 0.41). The sensitivity and specificity of F-wave inversion for the diagnosis of early stage CTS were calculated as 53.3% and 93.3%, respectively. The addition of F-wave inversion measurement to the set of the routine nerve conduction studies can increase the reliability of the electrophysiological studies in patients with early stage CTS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Echocardiographic Epicardial Fat Thickness and Neutrophil to Lymphocyte Ratio Are Novel Inflammatory Predictors of Cerebral Ischemic Stroke
(Elsevier Science Bv, 2014) Akil, Esref; Akil, Mehmet Ata; Varol, Sefer; Ozdemir, Hasan Huseyin; Yucel, Yavuz; Arslan, Demet; Akyuz, Abdurahman
Background: The role of epicardial fat thickness (EFT) in ischemic stroke (IS) has not been previously investigated. The aim of the present study was to evaluate EFT and neutrophil/lymphocyte ratio (NLR) among patients with IS and to examine the relationship between these inflammatory markers and the incidence of IS. Methods: The cross-sectional design includes 38 patients with IS and 47 age- and sex-matched healthy controls. Echocardiographic measurement of EFT was conducted according to previously published methods. An automated hematology analyzer was used to generate total and differential leukocyte counts from patient blood samples. Results: Mean EFT was 4.86 +/- .68 mm in the control group and 5.95 +/- 1.14 mm in the IS group. EFTwas significantly greater in the IS patients in relation to the control group (P < .001). Mean NLR was significantly greater among IS patients in relation to the control group (2.5 +/- .6 vs. 1.8 +/- .4, P < .001). No significant confounding factors were identified in the data set. Spearman's correlation analysis revealed a mild, but highly significant correlation between EFT and NLR (r = 5.293, P =.006). Conclusions: This study demonstrates for the first time the association between EFT and cerebral IS. Echocardiographic EFT was significantly correlated with NLR. NLR and echocardiographic EFT represent inexpensive and readily available clinical markers that maybe useful in estimating risk of IS.
Evaluation of serum oxidant/antioxidant balance in multiple sclerosis
(Springer Heidelberg, 2012) Acar, Abdullah; Cevik, M. Ugur; Evliyaoglu, Osman; Uzar, Ertugrul; Tamam, Yusuf; Arikanoglu, Adalet; Yucel, Yavuz
The total oxidative status (TOS)/total anti-oxidative status (TAS) ratio can provide information on an individual's absolute oxidative stress index (OSI). We investigated the alterations in the oxidant-antioxidant balance by measuring the oxidant parameters OSI, TOS, and malondialdehyde (MDA) together with the antioxidant parameters such as TAS, and superoxide dismutase (SOD) in patients with relapsing remitting multiple sclerosis (MS). To our knowledge, this is the first study to evaluate OSI in patients with relapsing remitting MS. 35 ambulatory patients with relapsing-remitting MS (35.8 +/- A 8.7 years) and 32 age- and activity-matched healthy control subjects (35.1 +/- A 3.7 years) that participated in the study. Serum TAS and TOS levels were determined using new automated methods. MS patients had higher concentrations of MDA (151.5 +/- A 51.1 vs. 111.3 +/- A 27.4 nmol/g protein, respectively; p < 0.001), TOS (148.1 +/- A 162.5 vs. 48.3 +/- A 46.4 mmol H2O2 Equiv./g protein, respectively; p = 0.002), OSI (21124 +/- A 32543 vs. 5294 +/- A 5562, respectively; p = 0.008), and SOD (4.5 +/- A 0.7 vs. 3.4 +/- A 0.6 U/L, respectively; p < 0.001) compared with healthy controls. On the other hand, MS patients had lower concentrations of NO (12.3 +/- A 6.9 vs. 17.4 +/- A 2.5 mu mol/g protein, respectively; p < 0.001) and TAS (0.82 +/- A 0.27 vs. 0.26 +/- A 0.15, respectively; p = 0.011) compared with healthy controls. In conclusion, these findings indicate that the oxidative stress plays an important role in the pathogenesis of MS.
Facial diplegia: etiology, clinical manifestations, and diagnostic evaluation
(Assoc Arquivos Neuro- Psiquiatria, 2015) Varol, Sefer; Ozdemir, Hasan Huseyin; Akil, Esref; Arslan, Demet; Aluclu, M. Ufuk; Demir, Caner F.; Yucel, Yavuz
Objective: Facial diplegia (FD) is a rare neurological manifestation with diverse causes. This article aims to systematically evaluate the etiology, diagnostic evaluation and treatment of FD. Method: The study was performed retrospectively and included 17 patients with a diagnosis of FD. Results: Patients were diagnosed with Guillain-Barre syndrome (GBS) (11), Bickerstaff's brainstem encephalitis (1), neurosarcoidosis (1), non-Hodgkin's Lymphoma (1), tuberculous meningitis (1) herpes simplex reactivation (1) and idiopathic (1). In addition, two patients had developed FD during pregnancy. Conclusion: Facial diplegia is an ominous symptom with widely varying causes that requires careful investigation.
Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine
(Bmc, 2011) Uzar, Ertugrul; Evliyaoglu, Osman; Toprak, Guelten; Acar, Abdullah; Yucel, Yavuz; Calisir, Tugba; Cevik, Mehmet Ugur
Asymmetric dimethylarginine (ADMA) has been found as correlated with endothelial dysfunction and oxidative stress. There are few studies regarding ADMA and nitric oxide (NO) levels in patients with migraine and alterations of ADMA and NO levels during migraine attack are not well-known. Therefore, in present study, we aimed to measure NO and ADMA levels in patients with migraine and compare them with the control group to investigate the correlation between migraine, oxidative stress and endothelial dysfunction. The migraine group consisted of 59 patients, including 22 suffering from migraine with aura and 37 suffering from migraine without aura. The control group consisted of 31 healthy volunteers without headache. The patients in migraine group were divided into subgroups based on whether attack period was present or not and whether it was migraine with or without aura. Plasma ADMA levels were measured using an enzyme-linked immunosorbent assay method. Migraine patients had higher concentrations of NO (35.6 +/- A 7.7, 31.0 +/- A 6.2 mu mol/L, respectively, p = 0.005) and ADMA (0.409 +/- A 0.028, 0.381 +/- A 0.044 mu mol/L, respectively, p = 0.001) levels when compared with the healthy controls. During migraine attack, NO and ADMA levels were found to be significantly higher in migraine group as compared to control group (respectively, p = 0.015, p = 0.014). Similarly, NO and ADMA levels in the patients with migraine in the interictal period were found to be significantly higher as compared to control group (p = 0.011, p = 0.003). In conclusion, higher ADMA and NO levels of patients with migraine supported that oxidative stress and endothelial dysfunction may have a role in migraine pathogenesis.
Increased fibrinogen, D-dimer and galectin-3 levels in patients with migraine
(Springer-Verlag Italia Srl, 2014) Yucel, Yavuz; Tanriverdi, Halis; Arikanoglu, Adalet; Varol, Sefer; Kaplan, Ibrahim; Akil, Esref; Celepkolu, Tahsin
There are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism, d-dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change during the attacks in patients with migraine. The present study aims to compare galectin-3, fibrinogen and d-dimer levels in patients with migraine during the attacks and interictal periods, and to compare galectin-3, fibrinogen and d-dimer levels between patients with migraine and healthy controls to investigate the role of these parameters in the pathogenesis of migraine. Fifty-nine patients with migraine and 30 age-gender matched healthy control subjects were enrolled in the study. Blood galectin-3, fibrinogen and d-dimer levels were measured in patients with migraine. Patients with migraine had higher levels of galectin-3, fibrinogen and d-dimer compared to the healthy controls (p < 0.05). No statistically significant difference was found between galectin-3 and fibrinogen levels during the attacks and interictal period in the migraine group (p > 0.05). Migraine patients had higher d-dimer levels during the attacks compared to the patients in the interictal period in the migraine group (p = 0.05). In conclusion, we found increased levels of fibrinogen, d-dimer and galectin-3 in patients with migraine compared to the healthy control group. Furthermore, we showed increased galectin-3 levels in patients with migraine, and higher d-dimer levels during migraine attacks compared to the interictal periods for the first time. These findings may be associated with the hypercoagulability and neurogenic inflammation during migraine headaches.
Investigation of Mean Platelet Volume and Platelet Count in the Blood of Patients with Migraine
(Turkish Neurological Soc, 2013) Varol, Sefer; Akil, Esref; Cevik, Mehmet Ugur; Celepkolu, Tahsin; Yucel, Yavuz; Tanriverdi, Mehmet Halis; Aluclu, Mehmet Ufuk
Objective: Mean platelet volume (MPV) is an indicator for platelet function and activation. Studies researching MPV and platelet level on the patients with migraine are insufficient. In this study, we aimed to find a difference in MPV and platelet count in individuals with migraine compared to healthy controls, which are indicators for platelet activation. Material and Method: We recruited 193 patients (female/male: 128/65, average age: 31.66 +/- 9.01) who are referred to the Neurology Clinic of Dicle University, Faculty of Medicine between January 2010 and January 2012 and have been diagnosed with migraine according to 2004 diagnostic criteria of International Headache Society (IHS) and 119 healthy individuals (female/male: 73/46, averge age: 32.27 +/- 9.88) who are referred to the Family Practice Clinic and Blood Bank. We compared MPV and platelet counts between the patients with migraine and healthy controls. Both groups were similar in terms of age and gender. Results: A statistically insignificant increase was found in MPV in patients with migraine (7.98 +/- 1.34 fL) when compared to the control group (7.85 +/- 0.96 fL) (p=0.34). Platelet levels were significantly lower in patients with migraine (367.6 +/- 74.2) than the platelet levels of the control group (286.9 +/- 68.3) (p=0.02). Discussion: We found lower platelet levels in the patients with migraine compared to the control group. There was also statistically insignificant increase in MPV in patients with migraine, suggesting that these findings may indicate an insignificant platelet activation in patients with migraine. New prospective studies are needed on this subject.
Investigation of Mean Platelet Volume in Patients with Multiple Sclerosis
(Turkish Neurological Soc, 2011) Uzar, Ertugrul; Arikanoglu, Adalet; Yucel, Yavuz; Aydin, Birsen; Tanriverdi, Mehmet Halis; Tasdemir, Nebahat
Objective: Alterations in platelet function have been observed in patients with multiple sclerosis. Mean platelet volume is a marker of the platelet activity and is reported to be increased in vascular diseases. The aim of this retrospective study was to investigate the correlation between mean platelet volume and multiple sclerosis. Materials and Methods: The patient group consisted of 46 multiple sclerosis patients who were presented with multiple sclerosis attacks (males/females: 10/36, mean age: 34.3 +/- 9.4 year). In the multiple sclerosis patients, mean platelet volume values during the attack were compared with the mean platelet volume value after attack. Mean platelet volume values of patients were also compared with those of 38 age/sex-matched healthy individuals (males/females: 14/24, mean age: 36.4 +/- 10.4). Results: No difference was found in mean platelet volume values during the multiple sclerosis attack (8.0 +/- 1.2) versus after the multiple sclerosis attack (7.9 +/- 1.2), and no relation was found between mean platelet volume and Expanded Disability Status Scale (EDSS) parameters (p> 0.05). No difference was found in mean platelet volume values between the multiple sclerosis group (8.1 +/- 1.3) and control group (8.1 +/- 1.1) (p> 0.05). Conclusion: No significant change in mean platelet volume values was seen during the multiple sclerosis attack versus after the multiple sclerosis attack. This finding supports that platelet activation does not play an important role in the multiple sclerosis pathogenesis. However, the relation between multiple sclerosis and mean platelet volume should be investigated prospectively.
Investigation of Total Oxidants/Antioxidants in Patients with Intracerebral Haemorrhage
(Turkish Neurological Soc, 2013) Cevik, Mehmet Ugur; Acar, Abdullah; Yucel, Yavuz; Varol, Sefer; Akil, Esref; Arikanoglu, Adalet; Yuksel, Hatice
Objective: Although there are numerous studies about oxidants and antioxidants in patients with ischemic stroke, the number of studies on this subject in patients with intracerebral hemorrhage (ICH) is limited. Malondialdehyde (MDA) is an oxidant parameter investigated in patients with ICH, and total oxidant status (TOS) has not been investigated so far. We aimed to investigate in blood samples the oxidant parameters MDA and TOS, and the total antioxidant status (TAS) in patients with ICH. Material and Method: A total of 30 patients with ICH, admitted and treated at the Neurology Clinic in the Faculty of Medicine, University of Dicle and 30 control who had no stroke or any systemic disorders were included in the study. Peripheral vein blood samples taken from patients and controls were included in the first 24 hours after stroke. Serum TAS, TOS values were measured with the Erel method, a specific, fully automatic and colorimetric method, and serum level of MDA was measured with method of Ohkawa. Results: Compared to the control group, the serum levels of TAS, TOS and MDA were significantly higher in the ICH patients (p < 0.05). However, there was no correlation between serum TOS, TAS and MDA levels and Glasgow Coma Scale (GCS) total scores and hematoma volumes (p> 0.05). Discussion: The increase in the serum levels of MDA, TOS, and TAS in ICH patients may demonstrate that there is an increase in oxidative stress and this supports the fact that that oxidative stress may play a significant role in the pathogenesis of the ICH. However, the increase of these parameters was not found to be associated with hematoma volume and GCS in patients with ICH.
The Prevalence of Depressive Symptoms in Patients with Idiopathic Parkinson's Disease: Cross-Sectional Study from Somalia
(Dove Medical Press Ltd, 2024) Hassan, Mohamed Sheikh; Mohamed, Nur Adam; Yucel, Yavuz; Mohamed, Yusuf Abdirisak; Gokgul, Alper
Introduction: Depression is one of the most common non-motor symptom of Parkinson's disease (PD), with an increasing prevalence in recent years. It causes significant psychological consequences that affect the disease course, overall quality of life, and functioning. The objective of this study was to determine the prevalence of depression in outpatients with Parkinson's disease evaluated in the neurology clinic at tertiary hospital in Mogadishu, Somalia. Methods: A cross-sectional study was conducted among 50 PD patients without dementia to determine the prevalence of depression at the neurology clinic of the Mogadishu Somalia Turkiye Training and Research Hospital between February and November 2022. All eligible participants were interviewed by a team of doctors using a structured questionnaire that consisted of sociodemographics and clinical characteristics, the Beck Depression Inventory-II (BDI-II) for depression assessment, and the Modified Hoehn and Yahr Scale for PD staging. Results: Of the 50 PD participants, 60% were male and 58% were older than 60 years. 20% of them had a family history of PD and HTN as comorbid conditions. The prevalence of depression among the participants was 46% (95% CI 31.8-60.7). Of the patients with depression, 22% and 24% had mild and moderate depressive symptoms, respectively. The Mann-Whitney U-test revealed a statistically significant association between depression symptoms and the presence of comorbidity (chi 2 = 136.50, p<0.01). The Kruskal-Wallis test revealed a statistically significant association between depression symptoms and a longer duration of PD (chi 2 (2) = 18.21, p<0.01) and advanced stages of PD (chi 2 (2) = 13.74, p<0.01). Conclusion: This is the first study conducted on patients with PD in Somalia and found that a significant proportion of these patients experienced depressive symptoms. We also highlighted that factors such the presence of medical comorbidities, high monthly income, advanced PD stage, longer duration of PD, and use of multiple medications for PD were significantly associated with the presence of depressive symptoms.
Protective Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress in Diabetic Rat Sciatic Nerve
(Asian Network Scientific Information-Ansinet, 2012) Yucel, Yavuz; Celepkolu, Tahsin; Kibrisli, Erkan; Kilinc, Faruk; Beyaz, Coskun; Aluclu, Mehmet Ufuk; Basarili, Mustafa Kemal
There has been no report which investigates the effects of Caffeic Acid Phenethyl Ester (CAPE) on elevated levels of oxidative stress in sciatic nerve tissues of diabetic rats. Therefore, this study was undertaken to determine whether CAPE, by virtue of its antioxidant properties, could affect lipid peroxidation, nitric oxide (NO), Paraoxonase (PON-1) and the oxidant/antioxidant balance in the sciatic nerve of Streptozotocin (STZ)-induced diabetic rats. The rats were treated as follows: control; this group of rats (n = 9) received isotonic solution. Diabetic (STZ, untreated diabetic): STZ 50 mg kg(-1) b.wt. was given intraperitoneally for the induction to this group (n = 8). Diabetic+CAPE treatment (STZ+CAPE, CAPE-treated diabetic): diabetic rats (n = 8) received CAPE (10 mu mol/kg/day) for a period of 21 days beginning one week after the STZ administration. Biomarkers; Malondialdehyde (MDA), Total Oxidant Status (TOS), total antioxidant status (TAS), PON-1 and NO levels for oxidative stress in sciatic nerve of the rats were measured. We found a significant increase in MDA, NO and TOS levels along with a reduction in TAS levels and PON-1 activity in the sciatic nerves of the STZ-induced diabetic rats (at p<0.001). The MDA, TOS and NO levels in sciatic nerve were significantly reduced in the CAPE-treated diabetic group compared to the untreated diabetic group (at p<0.05). In conclusion, the results of this study demonstrated that CAPE exhibits protective effects against oxidative damage in the sciatic nerve tissues of diabetic rats.
Relationship of cognitive performance with prolidase and oxidative stress in Alzheimer disease
(Springer-Verlag Italia Srl, 2013) Arikanoglu, Adalet; Akil, Esref; Varol, Sefer; Yucel, Yavuz; Yuksel, Hatice; Cevik, Mehmet Ugur; Palanci, Yilmaz
Glutamate excitotoxicity and oxidative stress are held responsible for the pathogenesis of Alzheimer's disease (AD). Prolidase is known to have a crucial part in the recycling of proline for collagen synthesis. Elevated proline levels have been shown to increase glutamate concentration. To our knowledge, prolidase activity in AD has not yet been studied. In this study, we aimed to reveal the relationship of AD with oxidative stress and collagen turnover by comparing AD patients and healthy control group with regard to total antioxidant status (TAS), total oxidant status (TOS), and prolidase levels. Fifty patients (mean age, 72.5 +/- A 8.9 years) diagnosed with AD and a control group comprised of 39 healthy individuals (mean age, 69.1 +/- A 7.1 years) were compared relative to serum TAS, TOS, and prolidase levels. The relationship of cognitive performance with prolidase, TAS, and TOS was evaluated by Mini mental state examination (MMSE). Alzheimer's disease group demonstrated statistically significantly higher prolidase and TOS levels as compared to the control group (p = 0.01, p = 0.018, respectively). Total antioxidant status level was significantly lower in the dementia group than in the control group (p = 0.032). MMSE manifested a negative correlation with prolidase and TOS levels (p = 0.001, r = -0.33; p = 0.002, r = -0.32, respectively), while displaying a positive correlation with TAS levels (p = 0.002, r = 0.32). In conclusion, elevated prolidase and TOS levels along with reduced TAS concentrations suggest that oxidative stress and collagen breakdown are involved in the cognitive impairment in AD.
Serum Vitamin B12, Folic Acid and Ferritin Levels in Patients with Migraine
(Turkish Neurological Soc, 2011) Acar, Abdullah; Evliyaoglu, Osman; Uzar, Ertugrul; Yucel, Yavuz; Cevik, Mehmet Ugur; Guzel, Isil; Colpan, Leyla
Objective: It has been reported that disability due to migraine may be reduced with homocysteine-lowering treatment including folic acid and vitamin B12. In addition, periaqueductal gray matter iron deposits have been found recently to be increased in migraine patients. There are few studies regarding vitamin B12, folic acid, ferritin, and transferrin levels in patients with migraine. The aim of this study was to measure vitamin B12, folic acid, ferritin, and transferrin levels in patients with migraine and to compare them with the control group. Patients and Methods: Fifty-one consecutive newly diagnosed migraine patients who did not receive any vitamin supplement medication were enrolled. The study group consisted of 51 patients suffering from migraine with aura (n= 23) and migraine without aura (n= 28). The control group consisted of 28 healthy participants without history of headache, anemia or vitamin supplement. Serum vitamin B12, folic acid, ferritin, and transferrin levels were measured using a chemiluminescence method. Results: Migraine patients had significantly lower concentrations of vitamin B12 and folic acid compared with the healthy controls (for vitamin B12: 215.6 +/- 133.7 pg/mL vs. 289.9 +/- 12 pg/mL, respectively, p= 0.005; for folic acid: 6.74 (+/-) 4.31 pg/mL vs. 8.47 +/- 1.85 pg/mL, respectively, p= 0.048). The vitamin B12 levels were found to be significantly lower during attacks in migraine patients than in interictal periods (177.3 +/- 139.2 pg/mL vs. 252.5 +/- 119.5 pg/mL, p= 0.043). There were no differences in folic acid, and transferrin levels during attacks versus in the interictal period in patients with migraine (p>0.05). The ferritin levels were found to be significantly lower during attacks in migraine patients than in interictal periods (43.4 +/- 41.1 mg/mL vs. 75.4 +/- 51.7 mg/mL, respectively, p= 0.018). Conclusion: Migraine patients had lower serum vitamin B12 and folic acid levels than healthy subjects. These findings support that vitamin B12 and folic acid may have a role in migraine pathogenesis and may be included in migraine prophylaxis. Further, this study indicated that iron homeostasis is disturbed in migraine attacks.
Toxic Effects of Isoniazid and Rifampicin on Rat Brain Tissue: The Preventive Role of Caffeic Acid Phenethyl Ester
(Asian Network Scientific Information-Ansinet, 2012) Cevik, Mehmet Ugur; Acar, Abdullah; Tanriverdi, Halis; Varol, Sefer; Arikanoglu, Adalet; Yucel, Yavuz; Akil, Esref
To the best of present knowledge, the possible protective effects of Caffeic Acid Phenethyl Ester (CAPE), on possible Isoniazid (INH) and Rifampicin (RIF) induced neurotoxic effects in brain tissue have not been investigated yet. As such, the purpose of this experimental study was to investigate the effects of CAPE, on INH and RIF induced neurotoxicity in rat brain tissue. We measured Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD) activities, Malondialdehyde (MDA) and nitric oxide (NO) levels in the brain tissue of rats. Male Sprague-Dawley rats were divided into eight experimental groups, with ten animals in each group. These groups are consist of control group, INH-treated group, RIF-treated group, INH+RIF treated group, INH+CAPE treated group, RIF+CAPE treated group, INH+RIF+CAPE treated group and CAPE treated group. MDA and SOD levels in brain tissue were significantly higher and TAC levels were lower in the INH, RIF and INH+RIF treated groups (p<0.05) and TAC levels were lower in the INH, RIF and INH+RIF groups than in the control group (p<0.05). CAPE plus INH and/or RIF treatment caused a significant decrease in MDA levels in brain tissue (p<0.05). In addition, CAPE plus INH and/or RIF treatment caused a significant increase in TAC levels (p<0.05). In conclusion, we have shown that administration of INH and RIF is accompanied by increased lipid peroxidation and oxidants in rat brain tissue. CAPE may protect against INH and RIF-induced neurotoxicity. Therefore, CAPE supplementation may be used as a potential neuroprotective drug for antituberculosis therapy with INH and/or RIF.

Yazar "Yucel, Yavuz" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri