Investigation of Total Oxidants/Antioxidants in Patients with Intracerebral Haemorrhage
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neurological Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Although there are numerous studies about oxidants and antioxidants in patients with ischemic stroke, the number of studies on this subject in patients with intracerebral hemorrhage (ICH) is limited. Malondialdehyde (MDA) is an oxidant parameter investigated in patients with ICH, and total oxidant status (TOS) has not been investigated so far. We aimed to investigate in blood samples the oxidant parameters MDA and TOS, and the total antioxidant status (TAS) in patients with ICH. Material and Method: A total of 30 patients with ICH, admitted and treated at the Neurology Clinic in the Faculty of Medicine, University of Dicle and 30 control who had no stroke or any systemic disorders were included in the study. Peripheral vein blood samples taken from patients and controls were included in the first 24 hours after stroke. Serum TAS, TOS values were measured with the Erel method, a specific, fully automatic and colorimetric method, and serum level of MDA was measured with method of Ohkawa. Results: Compared to the control group, the serum levels of TAS, TOS and MDA were significantly higher in the ICH patients (p < 0.05). However, there was no correlation between serum TOS, TAS and MDA levels and Glasgow Coma Scale (GCS) total scores and hematoma volumes (p> 0.05). Discussion: The increase in the serum levels of MDA, TOS, and TAS in ICH patients may demonstrate that there is an increase in oxidative stress and this supports the fact that that oxidative stress may play a significant role in the pathogenesis of the ICH. However, the increase of these parameters was not found to be associated with hematoma volume and GCS in patients with ICH.
Açıklama
Anahtar Kelimeler
Oxidative Stress, Intracerebral Hemorrhage, Glasgow Coma Scale
Kaynak
Turkish Journal of Neurology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
19
Sayı
1
