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Öğe Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree(Turkish J Pediatrics, 2017) Yildirim, Tuba Talo; Kaya, Filiz Acun; Taskesen, Mustafa; Dundar, Serkan; Bozoglan, Alihan; Tekin, Gulucag Giray; Akdeniz, SedatKindler syndrome (KS) is a rare genetic disorder. The clinical features include aggressive periodontal disease and severe desquamative gingivitis. Five individuals with KS were assessed by oral examination, radiographic analysis and periodontal measurements. All the patients' indexes were recorded prior to periodontal treatment and at the end of the 1th, 3th, 6th, 9th and 12th month respectively. All the patients had improvement of periodontal status and enhancement in index scores. The affected individuals were previously screened for FERMT1 mutations. KS patients' periodontal disease activity could be taken under control with regular follow-up.Öğe Ağız ve diş sağlığında probiyotiklerin potansiyel etkileri(Dicle Üniversitesi Diş Hekimliği Fakültesi, 2019) Tanhan, Mehmet; Kaya, Filiz AcunAntimikrobiyal ajanlar ve antibiyotikler; endojen ve eksojen mikroorganizma kaynaklı enfeksiyonlardan korunmada ve bu enfeksiyonların tedavisinde; mekanik tedaviyle birlikte uzun yıllardan beri kullanılmaktadır. Fakat bazı önemli patojenlerin antibiyotik direnci geliştirmesi ve meydana gelen yaygın antibiyotik direnci riski birçok antibiyotiğin önemli hastalıklara yönelik kullanımını yetersiz hale getirmiştir.Bu sebeple hastalıklara yönelik antibiyotik kullanımını en aza indirgemek amacıyla yeni fakat antibiyotik temelli olmayan alternatif çözümlerin arayışına gidilmiştir.Bunların içinde en dikkat çeken yaklaşım ise insan ve hayvan beslenmesine destekleyici ajanlar olarak probiyotiklerin eklenmesidir. Bu derleme, probiyotiklerin genel sağlık ve ağız-diş sağlığı üzerindeki potansiyel etkilerini incelemek amacıyla hazırlanmıştır.Öğe Associations of alveolar bone loss and interleukin-1 levels in one- and two-stage surgical procedures: a randomized prospective trial(Taylor & Francis Ltd, 2017) Yildirim, Tuba Talo; Kaya, Filiz Acun; Yokus, Beran; Colak, Mehmet; Kaya, Eylem Ozdemir; Tekin, Giray; Saribas, EbruObjective: Dental implants have been widely and successfully used in recent years as an alternative treatment for removable and fixed dental prostheses. The aim of this randomized prospective study was to determine the alveolar bone loss rate (ABLR) and IL-1 levels in one- and two-stage surgical procedures.Materials and methods: This study included 40 patients with a single missing tooth in the posterior mandible; dental implants were inserted using a one-stage surgical procedure (Group I) or a two-stage surgical procedure (Group II). All clinical periodontal parameters were recorded; peri-implant crevicular fluid (PICF) samples were collected before loading (T0) and during the third (T1) and sixth (T2) months after loading. ABLR values were evaluated at T0 and T2 by using dental tomography. PICF was analysed after T2 samples were collected. The study was registered through clinicaltrials.gov; identifier NCT03045458.Results: This study found that, the probing pocket depth was found to be significantly higher in Group I than Group II at both T1 and T2 (p<.05). There was no significant difference in other clinical parameters between the groups (p>.05). There was a significant difference between Group I ABLR values at T0 and T2 (p<.05). The PICF IL-1 levels were not significantly different between groups (p>.05).Conclusions: Within the limitations of the short observational period and small sample size of this study, two-stage implant placement shows comparable clinical outcomes to implants placed using a one-stage placement protocol.Öğe Bilateral twinned teeth and multiple supernumerary teeth(Quintessence Publishing Co Inc, 2008) Tumen, Emin Caner; Hamamci, Nihal; Kaya, Filiz Acun; Tumen, Demet Suer; Celenk, SemaDental twinning can result from the fusion of the developing dental germinal elements or the gemination of a single germ. In bilateral anterior and posterior dental twinning, problems such as poor esthetics, dental caries, arch-length problems, and periodontal disease often occur as a result of the irregular morphology. Several treatment methods have been described in the literature with respect to the different types and morphologic variations of twinned teeth, including endodontic, restorative, surgical, periodontal, and orthodontic treatment. This report documents the case of a young patient with an exceedingly rare phenomenon of permanent twinned teeth and multiple supernumerary teeth in both sides of the mandibular and maxillary arches, as a result of combined fusion and gemination.Öğe Clinical evaluation of complications in implant-supported dentures: A 4-year retrospective study(International Scientific Information, Inc., 2017) Ülkü, Sabiha Zelal; Kaya, Filiz Acun; Uysal, Ersin; Gülsün, BelginBackground: Implants that can be used in the prosthetic rehabilitation of full and partial edentulous patients are now frequently used due to advances in dentistry. Despite advanced methods of applications, failures and complications can still be seen. The aim of our study was to evaluate clinical prosthetic values and complications that occurred during 4-year follow-up in implant-supported restorations. Material/Methods: This retrospective study included 40 patients who received oral rehabilitation with an implant-supported prosthesis. A total of 162 implants were placed: 99 in the maxilla and 63 in the mandible. The prosthetic and surgical data were recorded. Data including prosthetic complications and implant loss were recorded and statistically analyzed using Cox proportional hazard regression analysis. Results: In total, 159 implants (98.14%) survived, 3 implants (1.86%) failed, and 100% of the protheses were successful. There were 62 dental implants used as abutments for removable dentures and 97 for fixed dentures. The most frequent prosthetic complications after placement of an implant-supported prosthesis were loss of retention, mucositis, abutment screw loosening, and fracture. Patient satisfaction after prosthesis use was also evaluated, showing that satisfaction was systematically increased. Conclusions: To minimize the frequency of complications, protocols must be established from diagnosis to the completion of treatment and follow-up of implant-supported prostheses, especially in terms of adequate technical steps and careful radiographic evaluation of the components.Öğe Crevicular fluid level of elastase in type i and type ii diabetes mellitus patients(2006) Doğru, Arzum; Çağlayan, Feriha; Dağ, Ahmet; Doğru, Mehmet; Kaya, Filiz AcunElastase activity in pocket fluid samples was taken from 120 patients divided into 4 groups. The groups were identified as Type I DM (Diabetes mellitus) metabolic uncontrolled, Type I metabolic controlled, Type II metabolic uncontrolled, and Type II metabolic controlled groups. The samples were evaluated with spectrophotometry. In our study we found that, in addition to the clinical data, elastase enzyme activity level and elastase enzyme concentration were found to be significantly higher in metabolic uncontrolled diabetic groups than in metabolic controlled groups (p<0.05). Furthermore, we found a relationship between total elastase enzyme activity and enzyme concentration in all of the four groups. The findings of the study support the relationship between elastase activity and the periodontal disease. We may further draw inferences regarding the effects of metabolic control levels on the periodontal tissues in diabetics patients.Öğe Effects of ELF-MF and Strontium Ranilate on Periodontium in Rats (Duble Blind)(Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Celik, Mustafa Salih; Kilinc, Nihal; Ozekinci, Selver; Saribas, EbruIn the present experimental study, it was investigated the periodontium of rats that exposed to Extremely Low Frequency-Magnetic Field (ELF-MY), overectomized bilaterally and treated with Strontium Ranelate (SR). The experiments were performed on 75 female Sprague-Dawley (4 months) rats. The rats were divided into five groups (n = 15). All rats were subjected to bilateral ovariectomy except those in I and III groups. Bilateral ovariectomy was performed before 4 days at the beginning of the experiments under ketamine anesthesia (100 mg kg(-1), intramuscularly) and II, IV and V groups animals were subjected to 1.5 mT ELF-MT exposure during 6 months, 4 h a day starting 5th day after the surgery. There were statistically significant differences among the all groups in the case of periodontal ligament, alveolar bone and gingiva (p<0.05). As a result of the study there were different levels of histopathologic changes occured between control and experimental changes in the case of all periodontal tissue examination. These results may hypothese that both ELF-MF and Strontium renalate have effects on periodontal tissues.Öğe Effects of Extremely Low Frequency Magnetic Fields on Periodontal Tissues and Teeth in Rats(Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Dasdag, Suleyman; Yavuz, Izzet; Kilinc, Nihal; Dogru, Arzum GulerThe aim of this study is to research the effects of ELF magnetic fields on periodontal tissues and teeth in rats histopathologically. The experiments were performed on 27 male Sprague-Dawley rats, aged 4 months at the beginning of the study, weighing (342.4 +/- 38.89) g and fed with standard pelleted food. The rats were divided into three groups; two experimental and one control (sham). Experimental groups were exposed to 100 and 500 mu T ELF magnetic fields during 10 months, 2 h a day, respectively. Third group was sham that were treated like experimental group except ELF magnetic fields exposure in methacrylate boxes. There was no statistical difference between the experimental groups among all tissues (p>0.05). Alveolar bone, pulp and gingiva there were statistically significant differences among the groups of sham and 1st experimental, sham and 2nd experimental (p<0.05). The statistical difference between the experimental and sham groups in the study makes us to think that ELF magnetic fields may have effects on periodontal tissues and teeth.Öğe Effects of Radiofrequency Radiation by 900 MHz Mobile Phone on Periodontal Tissues and Teeth in Rats(Medwell Online, 2008) Kaya, Filiz Acun; Dasdag, Suleyman; Kaya, Can Ayhan; Akdag, Mehmet Zulkuf; Yavuz, Izzet; Kilinc, Nihal; Kaya, SadullahThe aim of this study, is to research an answer to the question of have mobile phones effects on periodontal tissues and teeth. Twenty eight Wistar Albino adult male rats (4 months) with initial average weight of 267 +/- 15 g were obtained from the Medical Science Application and Research Center, caged individually and fed with standard pelletted food (TAVAS Inc. Adana, TR). They were separated into three groups such as cage control (n = 7), sham exposed (n = 7) and experimental (n = 14) and kept on a 14/10 h light/dark schedule. The rats were confined in a Plexiglas carousel and rat heads in the carousel exposed to 900 MHz microwave exposure emitted from generator. For the study group, rats exposed to the radiation 2 h per day (7 days in a week) for 10 months. Although, there was no statistical difference determined among the groups of experimental and sham groups (p>0.05), there were numerically more individuals effected of RF radiation in the experimental group. In our study is the statistically significant difference among the groups of experimental, sham and control groups in the case of vasodilatation in periodontal ligament and alveolar bone (p<0.05). By the histopathologic evaluation abnormal changes like vasodilatation and focal bleeding areas were determined in periodontal ligament, alveolar bone, gingiva and pulpa among some individuals. These degenerations were in different levels. These findings of our study indicates that there is need to more animal, human being and epidemiologic studies including much more individuals.Öğe ELF Electromagnetic Field and Strontium Ranilate Influences on the Trace Element Content of Rat Teeth(Medwell Online, 2009) Kaya, Sadullah; Akdag, Mehmet Zulkuf; Yavuz, Izzet; Celik, Mustafa Salih; Adiguzel, Oezkan; Tumen, Emin Caner; Kaya, Filiz AcunExposure to Extremely Low Frequency (ELF) Electromagnetic Field (EMF) emanating from the generation, distribution and utilization of electricity. The major debate in recent years has focused on the possibility that exposure to EMF may result some health consequences such as differentiation on bone constitute. In this study, the effect of ELF-EMFs and strontium ranelate on teeth constitute amount of mineral were investigated in rats. Seventy-five four month old adult female Sprague-Dawley rats were randomly divided into 5 different groups (n = 15). After all applications, some mineral levels such as: Ca, Mg and Zn in rat teeths were determined with Atomic Absorbtion Spectrophotometry (AAS) and the phosphorus content of teeth was determined by Ultraviolet Spectrophotometer (UVS). It was determined that the levels of Ca and P were not statistically different in comparison to Cg-Cnt and between groups (p>0.05). However, it was observed that the levels of Zn significantly alterations between some groups (p<0.05). The levels of Mg in ELF-EMF+OVX, ELF-EMF and OVX groups decreased significantly in comparison to Cg-Cnt group (p<0.05). As a result, it can be suggested that mineral amount of rat teeth can change after ovariectomy and ELF-EMF exposure, also strontium ranelate treatments can't increase mineral amount of teeth.Öğe Eroziv liken planusun oral bulguları: Bir olgu sunumu(Dicle Üniversitesi Tıp Fakültesi, 2007) Kaya, Filiz Acun; Sarıbaş, Ebru; Başkan, S. Zelal; İzol, Bozan Serhat; Kılınç, NihalEroziv liken planus, oral liken planusun hastaya en çok rahatsızlık veren formudur. Hastaların yeme, içme ve konuşma gibi fonksiyonları ciddi şekilde etkilenir. Deride ve mukozada lezyonlara neden olan hastalığın etiyolojisi çok iyi bilinmemekte ve otoimmünite suçlanmaktadır. Bu olgu sunumunda, Dicle Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalına başvuran 51 yaşındaki bir bayan hastanın oral bulguları rapor edilmiştir. Ekstraoral ve intraoral muayeneleri yapılmış, kesin tanı biyopsi ile konmuştur. Hastaya dermatoloji kliniğinde sistemik kortikosteroid tedavisi uygulanmıştır. Periodontal tedavileri yapıldıktan sonra da protetik restorasyonları yapılarak, fonksiyon, fonasyon ve estetik gereksinimler sağlanmıştır. Hastanın periyodik takiplerine devam edilmektedir.Öğe Evaluation of knowledge and attitudes of dentists and dental students about oral cancer(Ataturk University, 2025) Altındal, Dicle; Kaya, Filiz AcunObjective: This study aimed to evaluate the knowledge and negative attitudes of dentists and 4th-grade and 5th-grade students of dentistry towards oral cancer (OC). Methods: The study was conducted on 417 individuals consisting of 100 dentists, 186 5th-grade, and 131 4th-grade students. The questionnaire included questions on demographic characteristics, 10 questions measuring their knowledge about OC risk factors (knowledge-risk factors), 5 questions measuring their knowledge regarding the diagnosis of OC (knowledge-diagnostic procedures), and 11 questions assessing their attitudes towards OC (negative attitudes). Results: While there is no significant difference between dentists and 5th-grade students in knowledge-risk factors and knowledge-diagnostic procedures total scores, the total score of the 4th-grade students was statistically significantly different from these groups (P =.001). Looking at the negative attitudes total score, there is no significant difference between 5th and 4th-grade students, while total score of dentists was observed a statistically significant difference (P=.001). While knowledge-risk factors and knowledge-diagnostic procedures total scores were significantly and positively correlated (r=.287, P<.05), negative attitudes total score showed a significant negative correlation with knowledge-risk factors total score (r=.103, P<.05). Deficiencies were observed regarding the clinical characteristics of the prior oral lesion among participants. The group who considered leukoplakia and erythroplakia most likely to become precancerous lesions were 5th-grade students by 81.7%. Most participants indicated their need for further training, especially on OC and screening. Conclusion: In the study, deficiencies were observed in the groups about OC. Therefore, deficiencies should be assessed comprehensively at regional and national levels, and it should be addressed. Keywords: Dental student, dentists, knowledge, mouth neoplasms, risk factors, squamous cell carcinomaÖğe Evaluation of the behavior and health anxiety levels the patients applying to the periodontology clinic during the COVID-19 pandemic(Kerman Univ Medical Sciences, 2023) Altindal, Dicle; Kaya, Filiz Acun; Yildirim, Tuba Talo; Uysal, Ersin; Duger, NurullahObjective: The aim of this study was to evaluate the anxiety levels of orthodontic patients during the 1-year period in the ongoing pandemic. Methods: The study included patients between the ages of 12 and 30 years and who were continuing their fixed orthodontic treatment at Ad & imath;yaman University, Faculty of Dentistry, Department of Orthodontics and filled out the State-Trait Anxiety Inventory. A total of 266 patients filled out the questionnaire at their first clinical visit between June 8 and July 8, 2020 (T0) and 176 of 190 patients (response rate: 92.63%) that were still under treatment filled out the questionnaire for a second time between June 15 and July 16, 2021 (T1). Results: In the total population, there was a significant decrease in the State-Trait Anxiety Inventory-S score (P < .05), while there was no significant change in the State-Trait Anxiety Inventory-T score (P > .05). Anxiety scores were significantly higher in women and individuals aged over 18 years at T0 (P < .05), whereas only the anxiety scores of individuals aged over 18 years were significantly higher in T1 than in individuals aged below 18 years (P < .05). The State-Trait Anxiety Inventory-S score showed a significant decrease at T1 compared to T0 for female patients (36.02 +/- 11.32 vs. 38.82 +/- 9.84) and patients aged under 18 years (34.26 +/- 9.54 vs. 36.85 +/- 9.26) (P < .05). Conclusion: The state anxiety levels of orthodontic patients decreased during the 1-year period of the pandemic, while there was no significant change in their trait anxiety levels.Öğe Identification of interleukin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement(Oxford Univ Press, 2012) Hamamci, Nihal; Kaya, Filiz Acun; Uysal, Ersin; Yokus, BeranThe aim of this study was to identify the levels of interleukin (IL)-2, IL-6, and IL-8 around miniscrews used for anchorage during canine distalization. Sixteen patients (eight males and eight females; mean age, 16.6 +/- 2.4 years) who were treated with bilateral upper first premolar extractions were included in the study. Thirty-two maxillary miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars as anchorage units for maxillary canine distalization. Three groups were constructed. The treatment, miniscrew, and control groups consisted of upper canines, miniscrew implants, and upper second premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid (GCF) were obtained at baseline (T1) and at 1 (T2), 24 (T3), and 48 (T4) hours, 7 (T5) and 21 (T6) days, and 3 months (T7) after force application. Paired sample t-tests were used to determine within-group changes and Dunnett's t and Tukey's honestly significant difference tests for between-group multiple comparisons. During the 3 month period, IL-2 levels significantly increased (P < 0.01) but only in the treatment group after 24 hours. IL-6 levels were unchanged at all times points in the three groups. IL-8 levels increased significantly at 1 (P < 0.05), 24 (P < 0.01), and 48 (P < 0.01) hours in the treatment group and at 24 (P < 0.05) and 48 (P < 0.01) hours in the miniscrew group. It appears that miniscrews can be used for anchorage in orthodontics when correct physiological forces are applied.Öğe Identification of tumor necrosis factor- ? levels around miniscrews during canine distalization(Korean Assoc Orthodontists, 2011) Kaya, Filiz Acun; Hamamci, Nihal; Uysal, Ersin; Yokus, BeranObjective: The aim of this study was to measure tumor necrosis factor- alpha (TNF- alpha) levels around miniscrews used for anchorage during a 3-month period of canine distalization. Methods: Sixteen patients (8 boys, 8 girls; mean age, 16.6 +/- 2.4 years) whose upper first premolars were extracted for orthodontic treatment were included in this study. Miniscrews were used as an anchorage unit in canine distalization. Thirty-two (32) miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars. The treatment, miniscrew, and control groups comprised upper canines, miniscrew implants, and upper first premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid were obtained before applying force and at 1, 24, and 48 hours, and at 7 and 21 days, and 3 months after applying force. Results: During the 3-month period, the TNF- alpha levels increased significantly at 24 hours only in the treatment group (p < 0.01). In the miniscrew and control groups, there were no statistically significant changes. No significant differences were observed between groups. Conclusions: Miniscrews can be conveniently used for anchorage in orthodontics. (Korean J Orthod 2011;41(1):36-41)Öğe Interleukine-1? and tumor necrosis factor-? levels in the human gingival sulcus during orthodontic treatment(E H Angle Education Research Foundation, Inc, 2006) Basaran, Guvenc; Ozer, Torun; Kaya, Filiz Acun; Kaplan, Abdurrahman; Hamamci, OrhanObjective: To test whether interleukine 1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) levels differ from each other in different treatment levels. Materials and Methods: Eighteen patients, nine female and nine male (aged 16-19 years; mean 17.4 +/- 1.8 years), participated in this study. Each subject underwent a session on professional oral hygiene and received oral hygiene instructions. Two months later, a fixed orthodontic appliance was placed. The patients were seen at baseline, at days 7 and 21 and at the 3rd and 6th month as the leveling of the teeth occurred. Records of the baseline scores for the distalization forces were taken at the 6th month. Days 7 and 21 after 6 months of treatment were also recorded. Results: There were increases in the volume of gingival crevicular fluid (GCF) and in the concentrations of IL-1 beta and TNF-alpha. Conclusions: Leveling and distalization of the teeth evoke increases in both the IL-1 and TNF-alpha levels that can be detected in GCF.Öğe Interleukins 2, 6, and 8 levels in human gingival sulcus during orthodontic treatment(Mosby-Elsevier, 2006) Basaran, Guvenc; Ozer, Torun; Kaya, Filiz Acun; Hamamci, OrhanIntroduction: The aims of this study were to determine levels of interleukins 2, 6, and 8 during tooth movement, and test whether they differ from each other with leveling and distalization forces used in various treatment stages of standard orthodontic therapy. Methods: Fifteen patients (9 female, 6 male; ages, 15-19 years; mean age, 16.7 +/- 2.3 years) participated in this study. Each underwent a session of professional oral hygiene and received oral hygiene instructions. Two months later, a fixed orthodontic appliance was placed. The patients were seen at baseline, at days 7 and 21, and as the teeth were leveled. Records of the baseline scores for the distalization forces were taken at the sixth month. Scores of days 7 and 21 after 6 months of the distalization treatment were also recorded. Results: Increases were seen in the volume of gingival crevicular fluid and the concentrations of interleukins 2, 6, and 8. Conclusions: Leveling and distalization of the teeth evoke increases in interleukins 2, 6, and 8 levels in the periodontal tissues that can be detected in gingival crevicular fluid.Öğe The investigation of gingival crevicular fluid prosthoglandin e2 level of the type ii diabetes mellitus patients with periodontitis(2006) Kaya, Filiz Acun; Çağlayan, Feriha; Dağ, Ahmet; Kaya, Halil; Kaya, Can Ayhan; 0000-0003-2005-6100Diabetes mellitus (DM) is a risk factor for periodontal diseases and oral complications are frequently encountered in diabetic patients. In recent studies it was hypothesed that, the gingival crevicular fluid (GCF) prostoglandin E2 (PGE2) levels are higher in type I diabetic individuals than non diabetics. The aim of our study is to determine the GCF PGE2 levels of the individuals with type II dibetes mellitus and periodontitis. In addition it is aimed to investigate to correlation between the GCF PGE2 levels, the clinical parameters and the severity of the disease. 20 type II diabetes mellitus patient (group I), and 20 systhemic healthy (group II), a total of 40 individual with periodontiis were examined. All individuals pocket depth (PD), plaque index (PI), gingival index (GI), and gingival bleeding index (GBI) scores were recorded to determine their clinical status. In addition to these, the volume of GCF was also determined from the same sampling side. The GCF PGE2 levels were determined by radioimmunoassay (RIA) method. The GCF PGE2 levels of I. andII. groups were determined sequentally as 61.88±28.71 and 13.30±4.953pg/nm. The level of PGE2 level was determined significantly higher (p<0.001) in the group of diabetes mellitus patients than systhemic healthy group. Any correlation was not determined between the GCF PGE2 level and clinical parameters among both of the groups. By comparing all oral clinical parameters it was established that there was significiant differences between the groups (P<0.001). The PD and GCF amount of sampling site was also statistically different among the groups (p<0.05), but the difference of other parameter scores were not statistically important (p>0.05). The findings of this study confirms that diabetes mellitus is a risk factor for periodontal diseases and the correlation between GCF PGE2 level and the severity of the periodontal disease. Attracts attention for the GCF PGE2 level which could be used as a marker to determine the perodontal disease severity among type II diabetes mellitus patients.Öğe The investigation of the gingival crevicular fluid prostaglandin e2 level of the pregnant individuals with type ii diabetes mellitus and peridontitis(2006) Kaya, Filiz Acun; Çağlayan, Feriha; Dağ, Ahmet; Kaya, Can; Doğru, ArzumSysthemic diseases and hormonal changes are risk factors for periodontal diseases. In diabetes mellitus patients periodontal destruction is more severe than systhemic healthy patients. The increase of hormones during pregnancy causes more gingival inflammation and gestational gingivitis. In recent studies it was hypothesed that the increase of the level of progesteron in circulation stimulates the release of prostaglandin E2 (PGE2) which causes to gestational gingivitis. The aim of our study is to determine the level of PGE2 in gingival crevicular fluid (GCF) of the pregnant individuals with type II diabetes mellitus and periodontitis. In addition it is aimed to investigate the probable correlations between GCF PGE2 level and the clical parameters and periodontal disease severity. A total of 40 pregnant individual in 24–32 weeks with periodontitis (20 pregnant individual with type II diabetes mellitus, 20 pregnat individual systhemically healthy) were examined. To determine all the individuals periodontal status pocket depth (PD), plaque index (PI), gingival index (GI) and gingival bleeding index (GBI) scores were recorded. The volume of the GCF was also measured from the sampling site in addition to the other measurements. GCF PGE2 level was determined by radioimmunoassy (RIA) method. The GCF PGE2 level was determined as 38.27±26.08 pg/ml in type II diabetic pregnant group and 39.13±23.19 pg/ml in systhemic healthy pregnant group. There was no important difference of GCF PGE2 level among the groups (p>0.05). When the probable correlations between clinical parameters and GCF PGE2 levels were investigated there was found no correlation in healthy pregnant group, but there was correlation determined in type II diabetic pregnant group. When the full mouth clinical parameters were compared there was important differnces determined in the case of GI and GBI among the groups (p<0.01), but there was no important differences determined in the case of PD and PI (p>0.05). This study results establishes that there is no difference between type II diabetes mellitus pregnant patients with peiodontitis and sythemic healthy pregnants with periodontitis in the cases of GCF PGE2 level and periodontal disease severity. Pays attention that GCF PGE2 level can be used as a marker for determining the periodontal disease severity among type II diabetes mellitus pregnant patients as sythemic healthy pregnants.Öğe Is there a relation between dental calculus and kidney stone?(Uluslararası Diş Araştırmaları Birliği, 2021) Yıldırım, Kadir; Yıldırım, Tuba Talo; Kaya, Filiz AcunAim: The purpose of this research is to investigate the frequency of dental calculus in patients with kidney stone and without kidney stone. Methodology: Two hundred eighty-seven patients (143 men and 144 women) aged between 18 and 68 (mean age 38.38±13.74) were included in the study. Patients were divided two groups in which 143 subjects without kidney stones (group I) and 144 subject with kidney stones (group II). Intragroup and inter-group analyzes were performed in terms of periodontal status and dental calculus index according to educational level, frequency of toothbrushing and smoking. Results: The study sample consisted of 287 patients which 143 in group I, 144 in group II. The mean age of the group I was 36.77±12.81 years old, and group II was 39.98±14.47 years old. There was a statistically significant difference between periodontal status and education level, daily tooth brushing and smoking in group I and group II (p<0.05). Both in group I and group II there was a statistically significant difference periodontal calculus index and education level, smoking, daily tooth brushing (p<0.05). In addition, there were significant correlations between dental calculus index and size of the kidney stone. Conclusion: There is a significant difference between the groups in terms of dental calculus index. There is a need for additional study on this subject in the future.
