The investigation of the gingival crevicular fluid prostaglandin e2 level of the pregnant individuals with type ii diabetes mellitus and peridontitis

Systhemic diseases and hormonal changes are risk factors for periodontal diseases. In diabetes mellitus patients periodontal destruction is more severe than systhemic healthy patients. The increase of hormones during pregnancy causes more gingival inflammation and gestational gingivitis. In recent studies it was hypothesed that the increase of the level of progesteron in circulation stimulates the release of prostaglandin E2 (PGE2) which causes to gestational gingivitis. The aim of our study is to determine the level of PGE2 in gingival crevicular fluid (GCF) of the pregnant individuals with type II diabetes mellitus and periodontitis. In addition it is aimed to investigate the probable correlations between GCF PGE2 level and the clical parameters and periodontal disease severity. A total of 40 pregnant individual in 24–32 weeks with periodontitis (20 pregnant individual with type II diabetes mellitus, 20 pregnat individual systhemically healthy) were examined. To determine all the individuals periodontal status pocket depth (PD), plaque index (PI), gingival index (GI) and gingival bleeding index (GBI) scores were recorded. The volume of the GCF was also measured from the sampling site in addition to the other measurements. GCF PGE2 level was determined by radioimmunoassy (RIA) method. The GCF PGE2 level was determined as 38.27±26.08 pg/ml in type II diabetic pregnant group and 39.13±23.19 pg/ml in systhemic healthy pregnant group. There was no important difference of GCF PGE2 level among the groups (p>0.05). When the probable correlations between clinical parameters and GCF PGE2 levels were investigated there was found no correlation in healthy pregnant group, but there was correlation determined in type II diabetic pregnant group. When the full mouth clinical parameters were compared there was important differnces determined in the case of GI and GBI among the groups (p<0.01), but there was no important differences determined in the case of PD and PI (p>0.05). This study results establishes that there is no difference between type II diabetes mellitus pregnant patients with peiodontitis and sythemic healthy pregnants with periodontitis in the cases of GCF PGE2 level and periodontal disease severity. Pays attention that GCF PGE2 level can be used as a marker for determining the periodontal disease severity among type II diabetes mellitus pregnant patients as sythemic healthy pregnants.