Crevicular fluid level of elastase in type i and type ii diabetes mellitus patients

Elastase activity in pocket fluid samples was taken from 120 patients divided into 4 groups. The groups were identified as Type I DM (Diabetes mellitus) metabolic uncontrolled, Type I metabolic controlled, Type II metabolic uncontrolled, and Type II metabolic controlled groups. The samples were evaluated with spectrophotometry. In our study we found that, in addition to the clinical data, elastase enzyme activity level and elastase enzyme concentration were found to be significantly higher in metabolic uncontrolled diabetic groups than in metabolic controlled groups (p<0.05). Furthermore, we found a relationship between total elastase enzyme activity and enzyme concentration in all of the four groups. The findings of the study support the relationship between elastase activity and the periodontal disease. We may further draw inferences regarding the effects of metabolic control levels on the periodontal tissues in diabetics patients.