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Öğe Biomarker insights: Evaluation of presepsin, apelin, and irisin levels in cutaneous leishmaniasis(Mdpi, 2024) Erkan, Revşa Evin Canpolat; Tekin, Recep; Sula, BilalBackground/Objectives: Cutaneous leishmaniasis (CL) is a skin disease caused by Leishmania parasites. Presepsin, irisin, and apelin are biomarkers that are involved in the inflammatory response. The aim of this study was to investigate the association between serum levels of specific biomarkers, such as presepsin, apelin, and irisin, and the clinical features, location, number, and size of lesions in patients with CL. Methods: This study is a single-centre, prospective cohort study involving a total of 30 patients with skin lesions compatible with CL and 30 healthy matched controls. Age, sex, type of skin lesion, location of skin lesion, number of skin lesions, and diameter of skin lesions were recorded. The levels of presepsin, irisin, and apelin measured in the blood samples of the patient group were analysed in comparison to those in the healthy control group. Results: The findings revealed that presepsin levels were significantly elevated in the patient group compared to the controls (p = 0.000). However, no statistically significant differences were observed between the groups for irisin and apelin levels (p-values 0.096 and 0.836, respectively). A negative correlation was identified between presepsin levels and the number of skin lesions, the diameter of the largest lesion, and the total diameter of the lesions (p = 0.000). Conclusions: It appears that measuring presepsin levels in patients with CL may be beneficial. Presepsin has the potential to serve as a prognostic marker in CL, offering significant benefits in guiding clinicians in assessing disease progression and response to treatment.Öğe Evulation of prolidase enzyme, and galectin levels as a marker for fibrosis in patients with chronic hepatitis B(Verduci Editore s.r.l, 2022) Mermutluoğlu, Çiğdem; Tekin, Recep; Tekin, Rojbin Ceylan; Tekin, Salih; Erkan, Revşa Evin Canpolat; Deveci, Özcan; Aydoğdu, Gülay; Çelen, Mustafa Kemal; Dayan, SaimOBJECTIVE: The fibrosis can be detected using non-invasive methods including prolidase activity, proline levels and galectin-3 (GAL-3) detection in the serum. The aim of this study was to investigate the liver fibrosis through non-invasive methods in chronic hepatitis B patients. PATIENTS AND METHODS: This prospective case control study includes 56 patients with Chronic Active Hepatitis B (CAHB), 57 patients with Inactive Hepatitis B (IHB), and 60 healthy matched control subjects. The first group included the CAHB [hepatitis B surface antigen (HBsAg): positive; HBV DNA >2,000 IU/mL; normal or high alanine aminotransferase (ALT) value] undergo a liver biopsy, while the second group included the IHB (HBsAg: positive; HBV DNA: negative; normal ALT value). The third group comprised the healthy controls. Serum prolidase enzyme activities (SPEA), proline and galectin-3 levels were measured for each group. RESULTS: Patients with CAHB had significantly higher SPEA levels (1,004.3±186.8 IU/L) than did the controls (196.5±306 IU/L) (p<0.001). Significantly higher serum GAL-3 levels were found in the CHB group compared with HBV carrier and the control groups (27.4±32.2 ng/ mL, 6.5±13.4 ng/mL, 3.1±5.7 ng/mL, respectively, p<0.001). The relationship between serum prolidase activity, hidroxiprolyne and fibrosis (p<0.05). There were no significant differences in ALT levels between inactive HBV carriers and the control groups (p>0.05). CONCLUSIONS: We suppose that hidroxiprolyne levels and prolidase enzyme activity might be an indicator as a marker for fibrosis in CAHB and the evaluation of response to treatment.Öğe Hematological disorders after renal transplantation: A single-center study(İnönü Üniversitesi Tıp Fakültesi, 2023) Erkan, Revşa Evin Canpolat; Danış, RamazanAim: Post-transplantation anemia (PTA) and post-transplantation erythrocytosis (PTE) are the most common hematological problems in patients after renal transplantation. Hematological disorders need to be corrected to improve the mortality and morbidity status of patients and to maintain cardiac and graft functions. The objective of this study is to determine the prevalence of PTA and PTE in kidney transplant (KT) patients in our region in our organ transplant center. Materials and Methods: 212 renal transplant patients who underwent KT in a single center between 2012 and 2020 were included in the study. Demographic, clinical, and laboratory data of renal transplant patients at preoperative and postoperative months 6 and years 1, 2, 3, 4, and 5 were evaluated. Results: We determined the prevalence of PTA to be 28.16% (Early PTA 25.62%), and the prevalence of PTE to be 4.22%. The PTA group consisted of 40 patients, 33 females and 7 males, with a mean age of 30.5 years, while the PTE group consisted of only 6 male patients with a mean age of 21. Female predominance was observed in the PTA group (33, 82.5%), and male predominance (6, 100%) was observed in the PTE group. While there was no correlation between PTA and graft loss, there was a statistical correlation between PTE and graft loss (p<0.001). There wasn’t relationship between the groups in terms of mortality, tacrolimus, cyclosporin A, and erythropoietin use (p>0.05). We found a negative correlation between hemoglobin levels and urea and a positive correlation between albumin, Ca, and tacrolimus levels. Conclusion: PTA is a common condition, especially in female patients, and its prevalence increases over the years if the necessary care is not taken in the follow-up, and complications that may occur can be prevented with early diagnosis and treatment. Even if the prevalence of PTE is low, especially young male patients should be followed, and treatment should be started early to prevent a possible complications.Öğe Investigation of new inflammatory biomarkers in patients with brucella(Public Library of Science, 2024) Erkan, Revşa Evin Canpolat; Tekin, RecepBackground Delayed diagnosis and inadequate treatment of infectious and inflammatory diseases, such as Brucella, lead to high rates of mortality and morbidity. The aim of our study was to investigate the association between serum levels of apelin, presepsin, and irisin with inflammation, laboratory parameters, and blood culture in patients with brucella. Patients and methods This prospective case-control study involves 30 patients with brucellosis and 30 healthy, matched control subjects. Thirty patients who were diagnosed with brucellosis were aged ≥ 18 years. Blood samples were taken from the patients on the first day they were diagnosed with brucellosis. The values of irisin, presepsin, and apelin were studied. In addition, blood samples were also taken from 30 healthy individuals for the control group. Irisin, presepsin, and apelin values that were measured in the patients on the first day were compared with those values measured in the control group. Results The sex and age statuses of the subjects are matched among the groups. The levels of irisin were significantly higher in patients with brucellosis compared to the control group (p<0.045). There was no significant difference between the two groups in terms of apelin and presepsin levels (p values 0.087 and 0.162, respectively). There was a positive correlation between irisin levels and elevated ALT levels, as well as positive blood cultures. Conclusions It appears that the measurement of irisin levels may be beneficial in patients with brucellosis. Irisin can be used as a diagnostic marker for brucella infection and may greatly clinicians to predict the severity disease and treatment response. © 2024 Canpolat Erkan, Tekin. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Öğe Miyokard enfarktüsü hastalarında nesfatin düzeyi ve nesfatinin troponin ve CRP ile korelasyonu(Dicle Üniversitesi Tıp Fakültesi, 2022) Adıyaman, Mehmet Şahin; Erkan, Revşa Evin Canpolat; Kaya, İlyas; Adıyaman, Özlem AbaAmaç: Miyokard enfarktüsü (MI), kardiyovasküler hastalık kaynaklı mortalite ve morbiditenin başlıca sebeplerindendir. Aterosklerotik plak rüptürü sonucu gelişen akut tromboz en önemli nedendir. Gıda alımı ve enerji homeostazında etkili olan nesfatin araştırılan belirteçlerdendir. Çalışmamızda miyokard enfarktüsü ile nesfatin düzeyi arasındaki ilişkiyi tespit etmeyi amaçladık. Ayrıca nesfatin düzeyinin troponin ve CRP ile ilişkisini açıklamayı planladık. Yöntemler: Etik kurul onayı alınarak yapılan çalışmamıza, yeni tanı almış ve yatırılarak koroner anjiografi yapılmış akut koroner sendrom (AKS) hastaları dahil edildi. Obezite, kronik böbrek hastalığı, diabetes mellitus hastalığı olanlar dışlandı. Kontrol grubuna troponin değerleri yükselmeyen ve normal koroner anatomi tespit edilen 60 hasta dahil edildi. MI grubunda başvuru Ekg’sinde>2 mm st segment elevasyonu görülerek primer perkütan girişim yapılan 59 MI hastası değerlendirildi. Tüm hastalarda demografik bilgiler, hemogram, serum nesfatin, troponin, c-reaktif protein (CRP), lipid paneli ve diğer rutin biyokimyasal parametreler bakıldı. SPSS 22 istatistik paket programı kullanıldı. Bulgular: MI grubunda troponin, LDL, CRP, WBC değerleri anlamlı düzeyde yüksek izlendi (p<0,001). Nesfatin değerlerinin kontrol grubuna göre anlamlı düzeyde düşük olduğu görüldü (p<0.001). Erkek cinsiyetin MI grubunda ağırlıkta olduğu görüldü. MI grubundaki verilerde yapılan korelasyon analizinde nesfatin ile troponin, lipid profili, CRP ve WBC arasında pozitif veya negatif yönde anlamlı herhangi bir korelasyon ilişkisi görülmedi. Sonuç: Çalışmamızda, düşük serum nesfatin seviyelerinin MI ile ilişkili olabileceği gösterilmiş ve etyopatogenetik sebeplerden biri olabileceği desteklenmiştir. Artmış troponin, LDL, CRP ve WBC düzeyleri ile herhangi bir korelasyon ilişkisi tespit edilmemiştir. Bu ilişki, inflamatuar özellikleri ve hastalığın prognozunu göstermesi açısından destekleyici olmamıştır.
