Miyokard enfarktüsü hastalarında nesfatin düzeyi ve nesfatinin troponin ve CRP ile korelasyonu
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dicle Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Miyokard enfarktüsü (MI), kardiyovasküler hastalık kaynaklı mortalite ve morbiditenin başlıca sebeplerindendir.
Aterosklerotik plak rüptürü sonucu gelişen akut tromboz en önemli nedendir. Gıda alımı ve enerji homeostazında etkili
olan nesfatin araştırılan belirteçlerdendir. Çalışmamızda miyokard enfarktüsü ile nesfatin düzeyi arasındaki ilişkiyi
tespit etmeyi amaçladık. Ayrıca nesfatin düzeyinin troponin ve CRP ile ilişkisini açıklamayı planladık.
Yöntemler: Etik kurul onayı alınarak yapılan çalışmamıza, yeni tanı almış ve yatırılarak koroner anjiografi yapılmış akut
koroner sendrom (AKS) hastaları dahil edildi. Obezite, kronik böbrek hastalığı, diabetes mellitus hastalığı olanlar
dışlandı. Kontrol grubuna troponin değerleri yükselmeyen ve normal koroner anatomi tespit edilen 60 hasta dahil edildi.
MI grubunda başvuru Ekg’sinde>2 mm st segment elevasyonu görülerek primer perkütan girişim yapılan 59 MI hastası
değerlendirildi. Tüm hastalarda demografik bilgiler, hemogram, serum nesfatin, troponin, c-reaktif protein (CRP), lipid
paneli ve diğer rutin biyokimyasal parametreler bakıldı. SPSS 22 istatistik paket programı kullanıldı.
Bulgular: MI grubunda troponin, LDL, CRP, WBC değerleri anlamlı düzeyde yüksek izlendi (p<0,001). Nesfatin
değerlerinin kontrol grubuna göre anlamlı düzeyde düşük olduğu görüldü (p<0.001). Erkek cinsiyetin MI grubunda
ağırlıkta olduğu görüldü. MI grubundaki verilerde yapılan korelasyon analizinde nesfatin ile troponin, lipid profili, CRP
ve WBC arasında pozitif veya negatif yönde anlamlı herhangi bir korelasyon ilişkisi görülmedi.
Sonuç: Çalışmamızda, düşük serum nesfatin seviyelerinin MI ile ilişkili olabileceği gösterilmiş ve etyopatogenetik
sebeplerden biri olabileceği desteklenmiştir. Artmış troponin, LDL, CRP ve WBC düzeyleri ile herhangi bir korelasyon
ilişkisi tespit edilmemiştir. Bu ilişki, inflamatuar özellikleri ve hastalığın prognozunu göstermesi açısından destekleyici
olmamıştır.
Aim: Myocardial infarction (MI) is one of the main causes of cardiovascular disease-related mortality and morbidity. Acute thrombosis resulting from atherosclerotic plaque rupture is the most important cause. Nesfatin, which is effective in food intake and energy homeostasis, is one of the markers investigated. In our study, we aimed to determine the relationship between myocardial infarction and nesfatin level. We also planned to explain the relationship between nesfatin level and troponin and CRP. Method: Newly diagnosed patients with acute coronary syndrome (ACS) who underwent coronary angiography were included in our study, which was approved by the ethics committee. Those with obesity, chronic kidney disease, diabetes mellitus were excluded. The control group included 60 patients whose troponin levels did not increase and who had normal coronary anatomy. In the MI group, 59 MI patients who underwent primary percutaneous intervention due to >2 mm st segment elevation on the admission ECG were evaluated. Demographic information, hemogram, serum nesfatin, troponin, c-reactive protein (CRP), lipid panel and other routine biochemical parameters were evaluated in all patients. Results: Troponin, LDL, CRP, WBC values were significantly higher in the MI group (p<0.001). Nesfatin values were found to be significantly lower than the control group (p<0.001). It was observed that male gender predominated in the MI group. In the correlation analysis of the data in the MI group, no significant positive or negative correlation was found between nesfatin and troponin, lipid profile, CRP and WBC. Conclusion: In our study, it was shown that low serum nesfatin levels may be associated with MI and it was supported that it could be one of the etiopathogenetic reasons. No correlation was found with increased troponin, LDL, CRP and WBC levels. This relationship was not supportive in terms of inflammatory properties and prognosis of the disease.
Aim: Myocardial infarction (MI) is one of the main causes of cardiovascular disease-related mortality and morbidity. Acute thrombosis resulting from atherosclerotic plaque rupture is the most important cause. Nesfatin, which is effective in food intake and energy homeostasis, is one of the markers investigated. In our study, we aimed to determine the relationship between myocardial infarction and nesfatin level. We also planned to explain the relationship between nesfatin level and troponin and CRP. Method: Newly diagnosed patients with acute coronary syndrome (ACS) who underwent coronary angiography were included in our study, which was approved by the ethics committee. Those with obesity, chronic kidney disease, diabetes mellitus were excluded. The control group included 60 patients whose troponin levels did not increase and who had normal coronary anatomy. In the MI group, 59 MI patients who underwent primary percutaneous intervention due to >2 mm st segment elevation on the admission ECG were evaluated. Demographic information, hemogram, serum nesfatin, troponin, c-reactive protein (CRP), lipid panel and other routine biochemical parameters were evaluated in all patients. Results: Troponin, LDL, CRP, WBC values were significantly higher in the MI group (p<0.001). Nesfatin values were found to be significantly lower than the control group (p<0.001). It was observed that male gender predominated in the MI group. In the correlation analysis of the data in the MI group, no significant positive or negative correlation was found between nesfatin and troponin, lipid profile, CRP and WBC. Conclusion: In our study, it was shown that low serum nesfatin levels may be associated with MI and it was supported that it could be one of the etiopathogenetic reasons. No correlation was found with increased troponin, LDL, CRP and WBC levels. This relationship was not supportive in terms of inflammatory properties and prognosis of the disease.
Açıklama
Anahtar Kelimeler
CRP, Nesfatin, Miyokard enfarktüsü, Troponin, Myocardial infarction
Kaynak
Dicle Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
49
Sayı
4
Künye
Adıyaman, M. Ş., Erkan, R. E. C., Kaya, İ. ve Adıyaman, Ö. A. (2022). Miyokard enfarktüsü hastalarında nesfatin düzeyi ve nesfatinin troponin ve CRP ile korelasyonu. Dicle Tıp Dergisi, 49(4), 692-698.
