Yazar "Deveci E." seçeneğine göre listele
Listeleniyor 1 - 20 / 34
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Biochemical and histopathological investigation of resveratrol, gliclazide, and losartan protective effects on renal damage in a diabetic rat model(Science Printers and Publishers Inc., 2015) Ezel T.; Kocyigit Y.; Deveci E.; Atamer Y.; Sermet A.; Uysal E.; Aktaş A.OBJECTIVE: To compare the protective effects of resveratrol, gliclazide, and losartan, at biochemical and histopathological levels, on the rat kidney with experimentally induced type 1 diabetes. STUDY DESIGN: A total of 35 adult male Wistar rats were divided into control, diabetic, diabetic gliclazide, diabetic resveratrol, and diabetic losartan groups. For biochemical analysis, based on one of the kidneys, superoxide dismutase, malondialdehyde, and catalase were used for measurement. The other kidney was stained for histochemical and immunohistochemical markers and examined by light microscopy. RESULTS: Nephropathy due to diabetes was developed at the end of the third week in the diabetic group: in the glomeruli, contraction from Bowman distance, diffuse mesangial matrix increasing and tubular dilation, and cytoplasmic vacuolar changes were observed. In tubulointerstitial areas, some tubular structures, an increased expression of VEGF was observed. CONCLUSION: As a result, in diabetic rats, the effects of gliclazide, resveratrol, and losartan cure were equivalent to each other according to the parameters which were followed. Resveratrol, gliclazide, and losartan significantly protected renal glomeruli and the proximal and distal tubules. © Science Printers and Publishers, Inc.Öğe A case report of spleen tuberculosis treated by splenectomy(2004) Önen A.; Yaramiş A.; Şenyi?it A.; Deveci E.A 4-years-old boy who had weakness, anorexia, coughing, fever, night sweats, and weight loss that had persisted for 20 months admitted to our institution. Although he had received three antituberculous agents due to pulmonary tuberculosis for almost a year, there has been no significant improvement in his overall condition. Micronodular infiltration in chest x-ray, multiple nodules and/or small abscesses in the spleen in abdominal ultrasound and computerized tomography were found. Because of the failure of antituberculous therapy, splenectomy has been performed. Intraoperatively, the spleen was completely calcified and covered with multiple nodules and micro abscesses. Following the splenectomy, the patient's symptoms resolved and he began to gain weight. He received antituberculous therapy for two years concomitant with surgery. After 4 year-follow up, he still had no symptom and continued to do well with normal growth. The incidence of spleen tuberculosis has increased recently. The suspicion of tuberculous spleen abscess especially in endemic area and early diagnosis with early nonoperative management is important. The cases associated with severe drug resistant multiple tuberculous spleen abscesses that delayed in tuberculous treatment may benefit from splenectomy.Öğe Changes in the bladder after spinal cord injury and expression of VEGF and APAF-1(Science Printers and Publishers Inc., 2021) Yariş M.; Deveci E.OBJECTIVE: A spinal cord injury (SCI) is damage to the spinal cord either from trauma, loss of its normal blood supply, or compression from tumor or infection. In this study we focused on alterations in the bladder tissue with angiogenic and apoptotic aspects after spinal cord injury. STUDY DESIGN: Twenty Wistar Albino rats were categorized as control and SCI groups. At T7-T9 vertebras, a steel rod was dropped from 10 cm to create a spinal cord injury under anesthesia. Rats were decapitated and spinal tissue was processed to measure malondialdehyde (MDA), glutathione (GSH), and myeloperoxidase (MPO). RESULTS: MDA, MPO, epithelial degeneration, vascular dilation, inflammation, VEGF, and APAF-1 expressions in the SCI group were statistically higher than those in the control group. GSH content of the SCI group was statistically lower than that in the control group. In the hematoxylin-eosin–stained sections of the control group, normal histology was observed in bladder tissue. In the SCI group, degeneration epithelial cells, thinned epithelium, increased fibrosis, dilated and congested blood vessels, and hyperplastic endothelial cells were observed. In the control group, VEGF expression was slightly observed in some epithelial cells and vascular cells. In the SCI group, VEGF expression was increased in inflammatory and vascular endothelial cells. For APAF-1 expression, the control group showed no expression. In the SCI group, APAF-1 expression was positive in degenerated epithelial cells and connective tissue cells. CONCLUSION: It is thought that the urination reflex was affected due to increased inflammation in the bladder tissue, leading to alterations in the regulation and function of the muscles. © Science Printers and Publishers, Inc.Öğe Effect of graft application and nebivolol treatment on tibial bone defect in rats(Science Printers and Publishers Inc., 2021) Gem M.; Şahin L.; Uzel K.; Ermiş I.S.; Deveci E.OBJECTIVE: To evaluate the results of the effect of nebivolol on tibial bone defect and graft application in new bone development in the rat. STUDY DESIGN: Thirty Wistar albino rats were divided into 3 groups. In the Control group, tibia bone defect was created without any treatment. In the Defect+ Graft group, allograft treatment was performed by forming a 6 mm tibial bone defect. In the Defect+Graft+ Nebivolol group, alloplastic bone graft was placed in the calvarial bone defect and then nebivolol (0.34 mg/mL solution/day) treatment was intraperitoneally applied for 28 days. RESULTS: Histopathological examination revealed inflammation in the defect area, congestion in the vessels, degeneration in collagen fibers, and an increase in osteoclast cells. There was an increase in inflammation and blood vessel structure in graft application, and osteoblastic activity matrix formation after reorganization nebivolol application in collagen fibers. Osteonectin expression was positive in the collagen fiber and matrix, starting in the Graft group, in osteoblasts, whereas in the Nebivolol group, osteoblasts increased in osteocytes and new bone formation. CONCLUSION: Nebivolol is thought to have a positive effect on osteoinductive bone growth factors and contribute to the cell-matrix interaction, in addition to the supporting effect of the graft with its antioxidative effect. © Science Printers and Publishers, Inc.Öğe The effect of tamoxifen on the neonatal development of rat glans penis(1997) Deveci E.; Önen A.; Tacar O.; Yildirim A.From the first day of birth to the fifth day, daily subcutaneous 100 ?g tamoxifen (Tx) was injected into new-born male rats. The penises that were taken totally were fixated in 10% formaline, and then they were put in paraffin inclusion. The paraffin sections were stained with Hematoxylen-Eosin. Verhoeff and Triple on days 7, 14, 21, 28, 35 and 60. The alterations in the development of glans penis construction were examined. We found that in the glans penis of animals which were given Tx, from the 21st day, the epidermal projections were erased slowly and on the 60th day the epidermal projections and keratinisation completely ceased altogether. As a result, the development of epidermal projections in rats which were given tamoxifen in the neonatal period were hindered.Öğe The effect of vitamin E on small intestine damage of ischemia- reperfusion in young rats(1998) Deveci E.; Goral V.; Yilmaz F.; Tacar O.; Demirant A.; Canoruc F.The effect of antioxidant agents on ischemia-reperfusion is well known. In this study 300 mg/kg of vitamin E was administered I.M to young rats for three consecutive. On day three, the mesenteric superior artery was held with atraumatic clamps for 30 minutes to create ischemia, and then exposed to 45 minutes of reperfusion. We took sections from the jejunum for histological examination, then observed the negative effect of ischemia reperfusion and protective effect of vitamin E.Öğe Effect of zoledronic acid application on different graft materials in calvarial bone defect models: An experimental analysis(Science Printers and Publishers Inc., 2016) Koparal M.; Gülsün B.; Deveci E.; Agacayak K.S.; Hamidi A.OBJECTIVE: To determine the effect of zoledronic acid on graft materials in bone calvarial defects. STUDY DESIGN: Eighty adult (12 weeks) Sprague-Dawley male rats weighing from 300-350 g were divided into groups: calvarial defect, calvarial defect+synthetic graft, and calvarial defect+xenograft. All groups received zoledronate intravenously for a week after surgery and were sacrificed at either 6 or 12 weeks after their operation. The rat calvariae were fixed in 10% neutral buffered formalin before decalcification in 10% ethylenediaminetetraacetic acid for 20 days. Calvarial bone samples were then dehydrated and processed for embedding in paraffin wax. Sections 5 ?m thick were stained with hematoxylin and eosin and examined by light microscopy. RESULTS: The effects of zoledronic acid, a third-generation nitrogen-containing bisphosphonate, on different graft materials in rats with critical-size calvarial defects were analyzed and compared. Significantly less graft resorption was identified in zoledronic acid-treated rats that had received a xenograft than in either the untreated rats or those with a synthetic graft. In the xenograft group primary ossification was visible at week 12, and the graft had entered the bone to a greater extent than in the other experimental groups or in the control group. Osseous structures were also observed more clearly in this group than in the others. CONCLUSION: Zoledronic acid histopathologic bone graft stimulates bone formation. Zoledronic acid may be considered among the therapeutic methods available to improve the bone formation process in calvarial bone formation. © Science Printers and Publishers, Inc.Öğe Effects of adnexal torsion on the fallopian tube in rats: A histologic and immunohistochemical study(Science Printers and Publishers Inc., 2014) Tunç S.Y.; Ağaçayak E.; Yaman N.S.; Deveci E.; Kalkanli S.; Özler A.Objective: To investigate histopathological and immunohistochemical changes in the Fallopian tube structure following ovarian torsion. Study design: Thirty fertile, female, adult Wistar albino rats, weighing 200-220 g, were randomly divided into 3 equal groups (n=10): sham, torsion, and detorsion. In the torsion and detorsion groups, bilateral adnexal torsion (3-hour ischemia) was carried out. Bilateral adnexal detorsion (3-hour reperfusion) was performed in the detorsion group. Fallopian tube sections were stained hematoxylin and eosin, periodic acid-Schiff, Mallory-Azan and immunohistochemically-stained desmin, ? smooth actin, and CD68 antibodies. Results: In the sections of the ischemic group, degeneration of epithelium, loss of cilia, dilation of blood vessels, and hemorrhages were observed. Image analysis of the studied Fallopian section revealed a significant decrease in density of desmin in the torsion group. Moreover, strong positive cytoplasmic CD68 expression was observed in the torsion group. Conclusion: The use of effective antiinflammatory treatments may contribute to the conservative surgery in preservation of ovarian reserve and tubal structure. © Science Printers and Publishers, Inc.Öğe Effects of caffeic acid phenethyl ester on testicular torsion/detorsion injury in rats(Science Printers and Publishers Inc., 2018) Ipek H.; Dogan G.; Dogan G.; Deveci E.OBJECTIVE: To investigate the protective effect of caffeic acid phenethyl ester (CAPE) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury. STUDY DESIGN: Thirty male Wistar albino rats were randomly categorized into 3 groups: Sham, torsiondetorsion (T/D), and T/D+CAPE. Malondialdehyde (MDA), SOD, CAT, GSH levels, histopathological damage, and expression levels of endothelin-1 and ADAM-15 were examined in testicular tissue. RESULTS: The MDA level in the T/D group testes were significantly higher than those in the sham group. MDA levels of testes were lower in the CAPE-treated group than those in the T/D group. The T/D group had significantly lower SOD, CAT, and GSH levels in the testes than did the sham group. SOD, CAT, and GSH levels of the testes were lower in the CAPE-treated group than in the T/D group. In T/D group the thickness of the basal membrane in the tubules was increased, and degeneration and apoptosis in spermatogenetic cells, organization disorder in Sertoli cells, and sperm cells in the lumen were observed. The CAPE-treated group showed less atrophy and degeneration of the tubule epithelium than did the T/D group. CONCLUSION: It has been thought that CAPE administration after T/D testis damage may affect spermatogenesis development by inducing cell-cell junction by reducing apoptotic development which can regulate blood flow and microcirculation in testes. © 2018 Science Printers and Publishers, Inc.Öğe Effects of genistein, estrogen and progesterone therapies on bladder morphology and M2, M3 receptor expressions in oophorectomized rats(Acta Medica Mediterranea, 2014) Turgut A.; Goruk N.Y.; Sak M.E.; Deveci E.; Akdemir F.; Keles A.N.; Nergiz Y.Aims: Investigating the effects of estrogen, estrogen/progesterone combination and genistein therapy on the expression of M2 and M3 receptors located on bladder walls and comparing the morphological and degenerative changes exerted on bladder walls. Materials and methods: A total of 50 adult Sprague-Dawley female rats were randomly divided into five groups. Rats other than the sham group were ovariectomized. OVX group (control group) received water, OVX+G group received 10 mg/kg genistein, OVX+E group received 0.014 mg/kg 17-ß estradiol, OVX+E+P group received 0.014 mg/kg 17-ß estradiol plus 0.028 mg/kg drospirenone per day. Results: When compared with the sham group, in the OVX group higher collagen fibre (CF): smooth muscle (SM) ratio, relatively increased fibrosis, oedema, space between detrusor smooth muscle fascicles, cytoplasmic vacuoles, and total M2, and M3 expression were observed. Relative to the OVX group, decreased CF: SM ratio and fibrosis in the OVX+G, OVX+E, and OVX+E+P groups, decreased oedema, spaces between detrusor muscle fascicles and cytoplasmic vacuoles in the OVX+G group and lesser total M2, and M3 expression in the OVX+G, OVX+E and OVX+E+P groups were observed. Conclusion: Genistein therapy regresses unfavourable morphological changes effecting postmenopausal bladder and increases in M2 and M3 receptor expression more effectively than estrogen and estrogen/progesterone combination. Besides, genistein therapy almost completely regresses degenerative changes; however, estrogen and estrogen/progesterone combination therapies do not improve these degenerative changes except for fibrosis. We think that genistein will favourably contribute both to the conduction of more comprehensive studies in the future concerning its use in postmenopausal urinary incontinence where estrogen and estrogen/progesterone combination therapies do not provide any improvement and etiopathogenesis of urinary incontinence.Öğe The effects of lead at human and animals(2003) Özba? D.; Deveci E.Lead is an element that is absorbed via inhalation and ingestion and has toxic effects. Lead can accumulate in body, makes degenerative effects on the central and peripheric nervous system and has irritative effects on digestive system mucouse. Lead is a weakly mutagenic element, but, invitro, it inhibits DNA repair and acts synergistically with other mutagens. Lead must be absorbed and transported to target organs like brain, liver, kidney, and bone, before susceptible cells for lead become harmed. Lead had adverse effect on the development of organs in experimental animals, and young animals were more sensitive than old animals. When they take at a determined dose of lead for a certain time, pathological findings could be seen in organs (liver, kidney, bone, brain e.g.).Öğe Effects of Losartan on Ischemia/Reperfusion–Induced Testicular Injury in a Rat Testicular Torsion Model(Science Printers and Publishers Inc., 2020) Yariş M.; Deveci E.OBJECTIVE: To investigate the antioxidant effects of an AT1 receptor blocker losartan on the apoptosis of spermatogenic cells in torsion/detorsion damage in rats using the TUNEL assay method. STUDY DESIGN: Forty male Wistar albino rats were categorized into 4 groups. For Group 1 (sham group), only the abdominal wall was opened and closed. In Group 2 (torsion group), the left testis was rotated 720° degrees clockwise around the longitudinal axis of the spermatic cord for 2.5 hours. For Group 3 (torsion/ detorsion), after 2.5 hours of the torsion process, a suture that fixed the testis to the tunica dartos was cut off for detorsion for the following 3 hours. In Group 4 (torsion/detorsion+losartan), 2.5 hours of ischemia was followed by administration of 40 mg/kg losartan 30 minutes prior to a 3-hour detorsion/reperfusion. Biochemical assays (MDA, SOD, CAT, and GSH levels) and his-topathologic results were examined in testicular tissue. The TUNEL assay method was used for DNA fragmentation analysis in testicular seminiferous tubule sections. RESULTS: Losartan treatment seemed to prevent the increase in MDA levels of torsion/detorsion–induced testis. Statistically, SOD, CAT, and GSH activities were significantly decreased in the torsion/detorsion group, while they were increased in the torsion/detorsion+ losartan group. Testicular tubule diameter measurements were evaluated between groups. In the torsion and torsion/detorsion group, degeneration and loss in the germ cells together with organization disorder were observed. In the losartan application, degenerative changes were decreased and tubular structure was preserved. In the torsion and torsion/detorsion groups, an increase in apoptosis was observed in the germ cells in the tubules, and it was observed that the application of losartan decreased germ cell apoptosis. CONCLUSION: The experimental testis torsion/detorsion study suggests a protective role for losartan upon ischemia and ischemia/reperfusion injury in rat testes. © 2020 Science Printers and Publishers Inc.. All rights reserved.Öğe Effects of manganese ethylene-bis-dithiocarbamate (Maneb) on rat nasal respiratory mucosa(Acta Medica Mediterranea, 2013) Deveci E.; Yorgancilar E.; Ekinci C.; Koparal M.; Akkus Z.; Yavuz D.Maneb (Mn-ethylene(bis)dithiocarbamate is a dithiocarbamate pesticides. It is a fungicide pesticide used in the control of mildew disease on certain crops. In general, dithiocarbamates are considered chemicals of low toxicity for humans. However, the effects of maneb in humans are diverse. It has some effects to humans via absorption through skin and respiratory system. The nasal mucosa is the first part of the airways in contact with the environment and toxic agents. The aim of this study was todetermine the histopathological effects of maneb on nasal mucosa. In experimental group, the maneb was administered with inhalation to 10 male Wistar-Albino rats for five days a week. The control group (n=10) received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group,microscopic examination of nasal respiratory mucosa revealed; Hypertrophy of epithelial cells and goblet cells, increasing of mucus secretion, decreasing in sizes of cilia and flattening of the cells near the basement membrane and apoptotic cells in the degenerated respiratory epithelial cells, detected a mild inflammatory reaction and a vascular dilatation in the connective tissue. All changes were statistically significant. In control group of 10 rats no significant histopathologic lesions were found. As a result, our study , maneb is potentially toxic agent to respiratory mucosa.Öğe Effects of Nebivolol on Ischemia-Reperfusion Induced Testicular Injury in a Rat Testicular Torsion Model(Science Printers and Publishers Inc., 2021) Taş M.; Avınca O.; Karakoç Y.; Deveci E.OBJECTIVE: To investigate the antioxidant effects of nebivolol in spermatogenic cells against apoptotic and testicular inflammation in torsion-detorsion injury in rats by using TUNEL assay and immunohistochemical methods. STUDY DESIGN: Forty male rats were categorized into 4 groups: control group (abdominal wall was opened and closed), torsion group (left testis was rotated 720° clockwise around longitudinal axis of spermatic cord for 2.5 hours), torsion/detorsion group (after 2.5 hours of torsion process, the suture that fixed the testis to the tunica dartos was cut off for detorsion for the following 3 hours), and torsion/detorsion+nebivolol group (2.5-hour ischemia followed by administration of 10 mg/kg nebivolol 30 minutes prior to a 3-hour torsion/ detorsion). Biochemical assays (MDA, SOD, CAT, GSH) and histopathologic results were examined in the testicular tissue. TUNEL assay method was used for DNA fragmentation analysis in testicular seminiferous tubule sections. RESULTS: Nebivolol treatment seemed to prevent the increase in MDA levels of torsion-detorsion–induced testis. Statistically, SOD, CAT, and GSH activities were significantly decreased in the torsion/detorsion group, while they were increased in the torsion/detorsion+nebivolol group. In the torsion and torsion/detorsion groups, an increase in apoptosis was observed in the germ cells in the tubules, and it was seen that the application of nebivolol decreased germ cell apoptosis. CONCLUSION: Unilateral testicular torsion-detorsion causes testicular damage to the ipsilateral testis as evidenced by biochemical and apoptotic changes in the tissues and retains the morphological structure in the testes after nebivolol administration, after testicular torsion-detorsion damage, and decreased apoptotic index and inflammation. © Science Printers and Publishers, Inc.Öğe Effects of nicotine on rat tongue mucosa: Histopathological and immunohistochemical analyses(Science Printers and Publishers Inc., 2016) Eratilla V.; Uysal I.; Deveci E.; Güneş R.F.; Eratilla E.; Yildiz I.; Söker S.OBJECTIVE: To evaluate the histopathological and immunohistochemical effects of systemically administered nicotine on rat tongue mucosa. STUDY DESIGN: Rats were assigned to one of two groups: the experimental group received nicotine systemically (nicotine sulphate 2 mg/kg subcutaneously daily for 28 days), while the rats in the control group were administered physiological saline (1.5 mL subcutaneously for 28 days). All animals were sacrificed at the end of the study, and tongue tissue samples were removed and prepared according to routine histological procedures. Sections were stained with hematoxylin and eosin and observed by light microscopy. Immunoreactivity of tongue mucosa was assessed with E-cadherin, collagen IV, and VEGF expression by immunohistochemical staining. RESULTS: There were significant differences in the average histopathological score between the nicotine-treated and untreated groups. Morphological changes, including inflammatory leukocyte infiltration and cellular desquamation, blood vessel dilation, hemorrhage, and epithelial degeneration, were noted. Further, E-cadherin expression was significantly decreased in the nicotine-treated group versus the untreated group. The nicotine treatment group showed an increase in collagen IV secondary papillae and basal cells. CONCLUSION: The increased level of VEGF expression in the nicotine-treated group may have affected endothelial cell apoptosis. © Science Printers and Publishers, Inc.Öğe Effects of potentilla fulgens as a prophylactic agent in testicular ischemia-reperfusion injury(Science Printers and Publishers Inc., 2016) Karabulut Ö.; Kalkanli S.T.; Deveci E.; Isen K.; Uysal E.; Söker I.S.Objective: To study the protective effects of Potentilla fulgens extract on damage of testicular tissue created by ischemia and reperfusion treatment via histopathological, immunohistochemical, and TUNEL experiments. STUDY DESIGN: In this study 24 Sprague-Dawley male rats were divided into 4 subgroups: control group, torsion group, torsion-detorsion group, and Potentilla fulgens+torsion-detorsion group. The extract of Potentilla fulgens was intraperitoneally injected into the rats, 400 mg/kg for 5 days. The right testicle was exposed to torsion and detorsion for 2 hours with a 720° turn. The right testicle was dissected from the scrotum after the rats were anesthetized with ketamine hydroxide. Following fixation of 10% formaldehyde solution, routine tissue processing protocol was applied. Immunohistochemically slides were stained with TNF-? antibody. Apoptotic changes were examined using the TUNEL protocol. Results: In this study seminiferous tubule diameter and depth of spermatic cells were compared among the experimental and control groups. Histopathologic examination shows that degeneration and disorganization of the spermatic cells and changes in tubule diameter were found to be statistically significant. In addition, histopathological examination of the apoptotic indices was scored using the TUNEL method. Immunohistochemically, TNF-? expression was positively observed in the ischemia and the ischemia-reperfusion groups. Conclusion: As a result of torsion and detorsion exposure, which led to damage in spermatic cells of seminiferous tubules, Potentilla fulgens was shown to decrease apoptotic development and was thought to be the cause of activation in spermatic cells. © Science Printers and Publishers, Inc.Öğe Effects of urokinase on postoperative intraabdominal adhesion formation and healing of bowel anastomosis(1997) Otcu S.; Onen A.; Dokucu A.I.; Ozer M.; Isik B.; Deveci E.; Ozdemir E.Urokinase with its' proteolytic enzyme activity, has been frequently used in experimental studies on postoperative intraperitoneal adhesion formation. As wound healing process may be effected with the same mechanism, we aimed to investigate if intraperitoneal administration of urokinase increases the rate of anastomotic complications. For every ten rats of the control and urokinase group, laparotomy and colonic anastomosis are performed. In the urokinase group abdominal cavities are irrigated with 2000 IU of urokinase. All the rats are sacrificed at postoperative seventh day and adhesion scoring, anastomosis bursting pressure and histopathological findings are investigated. There is no anastomotic leakage in both groups. Adhesion score in control group (2.6±0.52) was significantly higher than urokinase group (1.1±0.74). Differences in anastomotic bursting pressure between the groups were not statistically significant. Although serosal and mucosal continuity were not achieved properly due to excessive fibroblastic activity in control animals, it could be obtained in the urokinase group sufficiently. Our findings support the efficacy of urokinase in preventing the postoperative intraabdominal adhesion formation, while the healing process at the anastomotic site is not alter with its' intraperitoneal administration.Öğe Endothelin-1 and APAF-1 Expression in the Umbilical Cord of Placenta Previa Cases(Science Printers and Publishers Inc., 2021) Taşin C.; Ermiş I.S.; Deveci E.OBJECTIVE: To investigate the changes occurring in the umbilical cord of abnormally located placenta previa cases histopathologically and immunohistochemically, together with the clinical data of inflammation and angiogenetic process. STUDY DESIGN: Ten normotensive umbilical cords and 10 placenta previa umbilical cords (a total of 20 umbilical cords) were processed for routine histological tissue processing. The biochemical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and APAF-1? and endothelin-1 (ET-1) immunostaining. RESULTS: Significant differences were observed in the comparison of the clinical data of placenta previa and normotensive cases. In the histopathological examination, increased inflammation, cell degeneration, and hyperplasia in endothelial cells were observed in the placenta previa group. It was observed that ET-1 expression and APAF-1 expression in placenta previa umbilical cord increased in endothelial cells and fibroblast cells as compared to the control group. CONCLUSION: It is thought that it accelerates the pro-apoptotic process due to the development of inflammation in the endothelium, muscle, connective tissue cells, and amniotic epithelium in the umbilical cord as a result of placenta previa, and it will affect the contractile structure and angiogenetic development in the umbilical cord and make a negative contribution to the nutrition of the fetus. © Science Printers and Publishers, Inc.Öğe Expression of beta human chorionic gonadotropin in the placenta of gestational diabetic mothers: An immunohistochemistry and ultrastructural study(2013) Sak M.E.; Deveci E.; Evsen M.S.; Kalkanli S.; Baran O.; Özekinci S.; Şeker U.Objective: To investigate morphologic differences of the placenta in pregnancies complicated by gestational diabetes compared to nondiabetic pregnancies. Study Design: This was a comparative morphological study of the placentas from 20 women with gestational diabetes and 20 healthy pregnancies at 28-35 weeks of gestation. Results: The presence of lesions such as fibrinoid necrosis, villous edema, syncytial knot and vascular lesions like chorangiosis was apparent, mainly in the diabetes group. There was an apparent decrease in the intensity of the human chorionic gonadotropin (hCG) immunostaining in the syncytiotrophoblast from the 28th to 35th weeks of gestation in the placentas of the healthy control group. No hCG immunostaining was observed in the villous or intervillous areas of any of the placentas. In diabetic placentas the expression of hCG was homogeneous with a moderate to intense immunoreactivity in the syncytiotrophoblast. Several syncytiotrophoblast cells showed dilations of both rough and smooth endoplasmic reticulum and loss and alteration of microvilli, and large vacuoles were observed just below the plasma membrane, as well as irregularities in the mitochondria. Conclusion: Syncytial cells play an important role in the placental transition. Increased expression of ß- hCG, deterioration, degeneration of organelles and cell structure and the basal membrane disorder in chorionic vessels were seen in placentas with gestational diabetes. These changes can affect placental transfer. However, further studies are needed to clarify this issue. © Science Printers and Publishers, Inc.Öğe Histopathological changes in liver of young rats treated with cadmium chloride during pregnancy(1998) Deveci E.; Goral V.; Tacar O.; Yaldiz M.; Canoruc F.In this study, cadmium chloride injection (I.V.) was administered to 17- 21 day pregnant Wistar Albino rats. The weight and liver histology of rats were then investigated. This short time administration of cadmium caused decrease in body weight and degeneration of liver structure in pregnant rats.
