The effects of lead at human and animals

Lead is an element that is absorbed via inhalation and ingestion and has toxic effects. Lead can accumulate in body, makes degenerative effects on the central and peripheric nervous system and has irritative effects on digestive system mucouse. Lead is a weakly mutagenic element, but, invitro, it inhibits DNA repair and acts synergistically with other mutagens. Lead must be absorbed and transported to target organs like brain, liver, kidney, and bone, before susceptible cells for lead become harmed. Lead had adverse effect on the development of organs in experimental animals, and young animals were more sensitive than old animals. When they take at a determined dose of lead for a certain time, pathological findings could be seen in organs (liver, kidney, bone, brain e.g.).