Yazar "Ağaçayak E." seçeneğine göre listele

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    Effects of adnexal torsion on the fallopian tube in rats: A histologic and immunohistochemical study
    (Science Printers and Publishers Inc., 2014) Tunç S.Y.; Ağaçayak E.; Yaman N.S.; Deveci E.; Kalkanli S.; Özler A.
    Objective: To investigate histopathological and immunohistochemical changes in the Fallopian tube structure following ovarian torsion. Study design: Thirty fertile, female, adult Wistar albino rats, weighing 200-220 g, were randomly divided into 3 equal groups (n=10): sham, torsion, and detorsion. In the torsion and detorsion groups, bilateral adnexal torsion (3-hour ischemia) was carried out. Bilateral adnexal detorsion (3-hour reperfusion) was performed in the detorsion group. Fallopian tube sections were stained hematoxylin and eosin, periodic acid-Schiff, Mallory-Azan and immunohistochemically-stained desmin, ? smooth actin, and CD68 antibodies. Results: In the sections of the ischemic group, degeneration of epithelium, loss of cilia, dilation of blood vessels, and hemorrhages were observed. Image analysis of the studied Fallopian section revealed a significant decrease in density of desmin in the torsion group. Moreover, strong positive cytoplasmic CD68 expression was observed in the torsion group. Conclusion: The use of effective antiinflammatory treatments may contribute to the conservative surgery in preservation of ovarian reserve and tubal structure. © Science Printers and Publishers, Inc.
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    Homeobox A Cluster 7 (HOXA7) protein expression increased in the placentas of patients with preterm delivery
    (Perinatal Medicine Foundation, 2023) Aşır F.; Oğlak S.C.; Ağaçayak E.; Alabalık U.
    Objective: This study aimed to investigate Homeobox A Cluster 7 (HOXA7) protein expression in the placentas of patients with preterm labor by immunohistochemical method. Methods: Placentas of 25 healthy women with term delivery and 25 women with preterm delivery were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recorded. HOXA7 immune activity was analyzed in the placental section with immunohistochemistry. Results: In the placentas in the term delivery group, normal histology was observed with no placental lesions. In placentas in the preterm delivery group, degenerated villi, fibrin deposition, and cytotrophoblast delamination with vascular congestion were recorded. HOXA7 protein expression was very high in preterm placentas compared to term placentas. The expression was obvious, especially in cytotrophoblast cells and villous connective tissue. Conclusion: HOXA gene family is required for proper placental formation. HOXA7 protein expression may be differently regulated in preterm placentas and may be involved in the pathogenesis of preterm delivery. © 2023 Perinatal Medicine Foundation.
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    WIPI-2 protein expression increases in the placentas of patients with preeclampsia
    (Perinatal Medicine Foundation, 2023) Aşır F.; Oğlak S.C.; Ağaçayak E.; Akkuş M.; Deveci E.
    Objective: This study aimed to investigate WD-repeat protein interacting with phosphoinositides-2 (WIPI-2) protein expression in the placentas of preeclamptic patients by immunohistochemical method. Methods: Placentas of 25 healthy normotensive women and 25 women with preeclampsia were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recor-ded. WIPI-2 immune activity was analyzed in the placental section with immunohistochemistry. Results: There was a high number of placental lesions such as vascular congestion, fibrinoid accumulation, hemorrhage, and villous degene-ration in preeclamptic placentas compared to normotensive placentas. WIPI-2 immune reaction was significantly increased in preeclamptic placentas when compared to normotensive placentas. WIPI-2 expression was predominantly observed in the placental villi. Conclusion: Autophagy is a process that occurs in normal placentation. However, dysfunction in the autophagic mechanism is observed in the placentas of preeclamptic patients and WIPI-2 expression could be used to show autophagy. © 2023 Perinatal Medicine Foundation.