WIPI-2 protein expression increases in the placentas of patients with preeclampsia
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Perinatal Medicine Foundation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: This study aimed to investigate WD-repeat protein interacting with phosphoinositides-2 (WIPI-2) protein expression in the placentas of preeclamptic patients by immunohistochemical method. Methods: Placentas of 25 healthy normotensive women and 25 women with preeclampsia were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recor-ded. WIPI-2 immune activity was analyzed in the placental section with immunohistochemistry. Results: There was a high number of placental lesions such as vascular congestion, fibrinoid accumulation, hemorrhage, and villous degene-ration in preeclamptic placentas compared to normotensive placentas. WIPI-2 immune reaction was significantly increased in preeclamptic placentas when compared to normotensive placentas. WIPI-2 expression was predominantly observed in the placental villi. Conclusion: Autophagy is a process that occurs in normal placentation. However, dysfunction in the autophagic mechanism is observed in the placentas of preeclamptic patients and WIPI-2 expression could be used to show autophagy. © 2023 Perinatal Medicine Foundation.
Açıklama
Anahtar Kelimeler
Autophagy, Endothelial Dysfunction, Hypoxia, Preeclampsia, Wıpı-2 Expression
Kaynak
Perinatal Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
31
Sayı
3
