Homeobox A Cluster 7 (HOXA7) protein expression increased in the placentas of patients with preterm delivery
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Perinatal Medicine Foundation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: This study aimed to investigate Homeobox A Cluster 7 (HOXA7) protein expression in the placentas of patients with preterm labor by immunohistochemical method. Methods: Placentas of 25 healthy women with term delivery and 25 women with preterm delivery were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recorded. HOXA7 immune activity was analyzed in the placental section with immunohistochemistry. Results: In the placentas in the term delivery group, normal histology was observed with no placental lesions. In placentas in the preterm delivery group, degenerated villi, fibrin deposition, and cytotrophoblast delamination with vascular congestion were recorded. HOXA7 protein expression was very high in preterm placentas compared to term placentas. The expression was obvious, especially in cytotrophoblast cells and villous connective tissue. Conclusion: HOXA gene family is required for proper placental formation. HOXA7 protein expression may be differently regulated in preterm placentas and may be involved in the pathogenesis of preterm delivery. © 2023 Perinatal Medicine Foundation.
Açıklama
Anahtar Kelimeler
Hox Genes, Placenta, Preterm Delivery
Kaynak
Perinatal Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
31
Sayı
3
