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Öğe 3-hydroxy fatty acids from the flowers of Hypericum lysimachioides var. lysimachioides(2004) Başhan, Mehmet; Toker, Zuhal; Keskin, Cumali; Özen, Hasan ÇetinFatty acid methyl esters in the leaves and flowers of Hypericum lysimachioides var. lysimachioides (Guttiferae) were analyzed by gas chromatography and gas chromatography-mass spectrometry. The flowers of H. lysimachioides var. lysimachioides produced unusual 3-hydroxy fatty acids [3-hydroxy- tetradecanoic acid (3-OH-C14:0) and 3-hydroxy-octadecanoic acid (3-OH-C18:0)], along with other normal fatty acids. Major components were linolenic and palmitic acids for both leaves and flowers.Öğe The antimicrobial activity of essential oils of Hypericum scabrum, Hypericum scabroides and Hypericum triquetrifolium(Wiley, 2004) Kızıl, Göksel; Toker, Zuhal; Özen, Hasan Çetin; Aytekin, ÇetinThe essential oils of Hypericum scabrum, Hypericum scabroides and Hypericum triquetrifolium were studied for the first time for their antimicrobial activity against nine organisms. All the essential oils exhibited some broad spectrum antibacterial activity, at a concentration of 80 mug/mL. The essential oils of Hypericum species showed antibacterial activity against the tested organisms and a yeast. Copyright (C) 2004 John Wiley Sons, Ltd.Öğe Astragalus diphtherites FENZL var. diphtherites ve astragalus gymnalopecias RECH. FIL’in gövde ve kök kısımlarından farklı çözücüler ile elde edilen özütlerin invitro antioksidan ve antimikrobiyal özelliklerinin belirlenmesi(Kahramanmaraş Sütçü İmam Üniversitesi, 2018) Keskin, Cumali; Özen, Hasan Çetin; Toker, Zuhal; Kızıl, Göksel; Kızıl, MuratBu çalışmanın amacı farkı polariteye sahip çözücü serilerinden geçiren Astragalus diphtherites var. diphtherites (A. diphtherites) ve Astragalus gymnalopecias (A. gymnalopecias) türlerinin gövde ve kök kısımlarının antioksidan ve antimikrobiyal özelliklerinin araştırılmasıdır. Antioksidan özellikleri belirlemek için özütlerin total fenolik, total flavonoid, DPPH, metal şelatlama, indirgeme gücü ve hidroksi radikalini söndürme aktiviteleri test edildi. En yüksek total fenolik bileşen miktarı A. diphtherites’ de gövdede metanol, kökte ise aseton özütünden elde edilirken A. gymnalopecias’ ta gövdede metanol kökte ise etil asetat özütünde tespit edildi. A. diphtherites ve A. gymnalopecias’ ta en yüksek total flavonoid miktarları ve indirgeme gücü aktiviteleri gövdede aseton kökte ise etil asetat özütlerinden elde edildi. A. diphtherites için en yüksek DPPH radikalini söndürme aktivitesi, gövdede metanol kökte ise aseton özütünde, A. gymnalopecias’ ta gövdede metanol kökte ise etil asetat özütünde tespit edildi. A. diphtherites’ te gövde kısmından elde edilen metanol ve kök kısmından elde edilen hekzan özütleri, A. gymnalopecias’ ta ise gövde ve kök kısımlarının metanol özütleri en yüksek metal şelatlama aktivitesi gösterdi. Her iki türde de gövde ve kök etil asetat özütleri en yüksek hidroksil radikali söndürme aktivitesi gösterdi. A. gymnalopecias’ın gövde aseton ve metanol özütlerinin Streptococcus pyogenes’in büyümesi üzerinde inhibisyon etkisine sahip olduğu tespit edildi.Öğe The composition of fatty acids in Hypericum scabrum, H. Scabroides and H. Amblysepalum(2003) Başhan, Mehmet; Özen, Hasan ÇetinThe chemical composition of the fatty acid methyl esters (FAMEs) of flowering tops of Hypericum scabrum, H. scabroides and H. amblysepalum were identified by gas chromatography. In this work 5 FAMEs for H. scabrum, 9 FAMEs for H. scabroides and 8 FAMEs for H. amblysepalum were identified. The major components were alpha-linolenic (48.60%), linoleic (32.53%) and oleic (11.45%) acids in H. scabrum. Alpha-linolenic (29.84%), palmitic (27.90%) and oleic (16.49%) acids were present in H. scabroides and alpha linolenic (41.79%) and palmitic acids (32.28%) were found in H. amblysepalum.Öğe Composition of the essential oil of achillea pseudoaleppica Hub.-Mor(2003) Özen, Hasan Çetin; Toker, Zuhal; Clery, Robin A.; Owen, Neil E.; 0000-0001-6670-6469; 0000-0003-1038-9091; 0000-0001-5157-8986Water-distilled essential oil from aerial parts of Achillea pseudoaleppica, an endemic species in Turkey, was analyzed by GC and GC/MS. Seventy components were characterized representing 92.4% of the total component in oil sample. The major components were camphor (29.1%), 1,8-cineole (17.7%) and artemisia ketone (10.3%).Öğe Cuscuta babylonica Aucher (Küsküt) parazitliğinin Alhagi maurorum ’un fenolik bileşikleri üzerine etkisi(2018) Asan, Hilal Surmuş; Özen, Hasan ÇetinParazit bitkiler, yeryüzünde konuk oldukları bitkilerin yaşamlarını sınırlandıran türlerdir. Küsküt türleri, yaprak ve kökleri olmayan tam parazit bitkilerdir. Bu bitkiler, su ve besin elementlerini özelleşmiş beslenme yapıları olan hostoryumları aracılığıyla diğer bitkilerden elde ederler. Parazit bitkiler konukçularıyla benzer hormonal mekanizmalar içerdikleri için hem onları etkilerler hem de onlardan etkilenirler. Parazit bitkilerin saldırısına uğrayan konukçu bitki, en etkin savunma maddeleri olan çeşitli fenolik bileşikler sentezler. Alhagi, Fabaceae familyasından Asya, Avusturalya ve Avrupa’nın çoğu ülkesinde geniş dağılım gösteren bir bitki cinsidir. Alhagi’nin farklı kısımları, antioksidant, kardiyovasküler, antiülser, diare önleyici, ateş düşürücü, anti romatizmal, antibakteriyel, antifungal gibi geniş bir biyolojik aktiviteye sahiptir. Bu çalışmada patojen Cuscuta babylonica Aucher (Cuscutaceae) enfeksiyonunun Alhagi maurorum bitkisinin fenolik bileşik içeriğinde meydana getirdiği değişiklikler LC-MS/MS analizleri kullanılarak incelenmiştir. Analizler sonucunda, küsküt enfeksiyonunun klorogenik asit (67.64 kat), apigenin (23.18 kat) ve kuersetin (6.75 kat)içeriklerinde önemli bir artışa neden olurken, bunun yanında hiperosid (3.94 kat), naringenin (2.92 kat), p-kumarik asit (2.28 kat), kuinik asit (2.08 kat), kumarin (1.74 kat), tr- caffeik asit (1.61 kat), salisilik asit (1.40 kat), 4-OH benzoik asit (1.36 kat), malik asit (1.109 kat) ve hesperidin (1.08 kat) bileşiklerinde de artış olduğu ortaya çıkarılmıştır. Protokateşuik asit miktarında 36.34 kat gibi kaydadeğer bir düşüş gözlenirken, yine kaemferol (5.04 kat), gallik asit (2.58 kat), vanillin (1.54 kat), tr-akonitik asit (2.41 kat), tannik asit (2.11 kat), rosmarinik asit (1.88 kat), rutin (1.044 kat) gibi bileşiklerin miktarında da düşüşe neden olmuştur. Hesperetin(0.268) ise sadece, enfekte olmuş bitkilerde tesbit edilmiştir. Enfekte olmadan önce ve enfeksiyon sonrası yapılan analiz sonuçları küsküt enfeksiyonunun Alhagi bitkisinin fenolik bileşen içeriğinde önemli değişimlere neden olduğunu ortaya koymuştur.Öğe Effect of BAP on total hypericin production in shoot cultures of Hypericum scabroides: An endemic species in the Eastern Anatolia region of Turkey(Foundation for Enviromental Protection and Research, 2015) Asan, Hilal Surmuş; Özen, Hasan Çetin; Onay, Ahmet; Asan, NurettinBackground: Due to the therapeutic importance of hypericin, a number of Hypericum species are being investigated. The aim of this study was to determine the effect of various BAP (6- benzylaminopurine) concentrations on seed germination, shoot proliferation, and total hypericin in a tissue culture of Hypericum scabroides which is endemic to the Eastern Anatolia region, Turkey. Material and Methods: Hypericum scabroides specimens were collected from Eastern Anatolia (Elazig, Turkey). The effects of various BAP concentrations (0.0 (control), 0.5, 1.0, and 2.0 mg/L) on seed germination, shoot multiplication, and the accumulation of total hypericin were determined using tissue cultures of H. scabroides. Murashige and Skoog (MS) medium was used for germination and shoot cultures. Measurements of total hypericin were taken using a UV spectrophotometer. Results: The best germination rate (59.2%) was obtained using hormone-free MS medium (control group). Apical tips of freshly germinated seedlings were proliferated on the MS medium supplemented with various BAP concentrations (0.5, 1.0, and 2.0 mg/L) and the control group (without BAP). The highest number of shoots (42.7 shoot/explant) and longest shoot length (2.50 cm) were obtained on MS medium supplemented with 2.0 mg/L BAP. Total hypericin was found in trace amounts and it was found that the total hypericin was not affected by the concentration of BAP. Conclusions: Our results showed that increasing concentrations of BAP stimulated shoot multiplication but did not affect seed germination rates or total hypericin in in vitro cultures of H. scabroides.Öğe The effect of cuscuta babylonica aucher (Cuscuta) parasitism on the phenolic contents of carthamus glaucus bieb.subsp. glaucus(Iğdır Üniversitesi Fen Bilimleri Enstitüsü, 2016) Asan, Hilal Surmuş; Özen, Hasan ÇetinCuscuta species are holoparazit plants which obtained all need water and organic material from host plants. The host plants are generally synthesized a variety of phenolic compounds in response to attack of parasitic plants. In this study, the plant Carthamus glaucus Bieb. subsp. glaucus (Compositae) used as host plant is an important plant that contains several compounds inhibit the STAT-3 gene is directly related to prostate cancer. In the study it was investigated that the effect of Cuscuta babylonica parasitism phenolic compounds of C. glaucus. The phenolic compounds of infected and uninfected C.glaucus plants analysed by LC/MS-MS. The results indicated a rise in phenolic contents that known as defense chemicals quinic acid, gallic acid, tr-caffeic acid, hyperoside, quercetin, and naringenin with dodder infestation. Besides in the content of tr-aconitic acid, vanillin, hesperidin, 4-OH-benzoic acid, salicylic acid and kaempferol decreased after dodder infestation.Öğe The Effect of cuscuta babylonica Aucher on chemical compounds of Lice tomato(Kahramanmaraş Sütçü İmam Üniversitesi Rektörlüğü, 2020) Özen, Hasan Çetin; Savaşçı, Servan; Asan, Hilal Surmuş; Kızmaz, VeysiTomato (Lycopersicon esculentum L.) is one of the most widely used products in nutrition. But this plant suffers significant loss of yield due to parasitic plant infection. Dodder (Cuscuta spss.), a flowering plant belonging to the Convolvulaceae family, is one of the most harmful parasites for tomatoes. Although some tomato varieties have developed resistance to this, Cuscuta is the most important disease that has a negative impact on tomato yield. In this study, it was investigated that how Lice tomato is affected by Cuscuta babylonica Aucher infection and whether it develops resistance to it. For this purpose, following Cuscuta infection, the amount of fatty acids, calcium (Ca2+) and some phenolic compounds in the leaves of the tomatoes were investigated. The results of the study showed that the Cuscuta infection increased the amount of 16:1, 18:0 and 18:1 fatty acids, Ca2+ and some phenolics such as chlorogenic acid, rutin, quercetin and salicylic acid which are effective in defense against pathogens.Öğe The effects of different concentrations of foliar applied chitosan, iron oxide and chitosan- coated iron oxide nanoparticles on the secondary metabolites of hypericum triquetrifolium turra. during full bloom(Kahramanmaraş Sütçü İmam Üniversitesi, 2022) Bal, Ayşe; Özen, Hasan Çetin; Tural, Birsen; Ertaş, ErdalHypericum triquetrifolium Turra. (Hypericaceae) is one of the important medicinal plants. This herb is used in Turkish folk medicine for its antidepressant, anthelmintic and antiseptic effects. Hypericum extracts have an important commercial value in the pharmaceutical industry. Therefore, studies to increase the amount of secondary metabolites it contains are becoming widespread. Elicitors are biological and non-biological factors that can affect the synthesis of secondary metabolites in plants. In recent years, nanoelicitors have been used to increase the amount of active ingredients. In this study, to stimulate the synthesis of biologically active secondary compounds of H. triquetrifolium; chitosan, iron oxide and chitosan-coated iron oxide nanoparticles in concentrations of 0 (control), 50, 75, 100 and 150 ppm were sprayed on the leaves during full bloom. LC-MS/MS analysis showed that application of 100 and 150 ppm chitosan nanoparticles increased the amount of flavonol (hyperocyte and quercitrin) and naphthodianthrons (pseudohypericin and hypericin) in H. triquetrifolium. 50 ppm iron oxide nanoparticle hyperocyte, quercitrin and pseudohypericin; 75 and 100 ppm iron oxide nanoparticles increased the amount of hyperocyte, quercitrin and hyperforin. The 150 ppm iron oxide nanoparticle resulted in an increase in all compounds except hypericin. In this study, iron oxide nanoparticles coated with chitosan were also used as elicitors to improve the chemical and biological properties of iron oxide. In this series, iron oxide nanoparticle coated with 100 ppm chitosan was effective and increased the amounts of quercitrine, kaempferol and pseudohypericin. The concentration of 75 ppm of this group was effective on quercitrin.Öğe Fatty acid and 3-hydroxy fatty acid composition of two Hypericum species from Turkey(Wiley, 2004) Özen, Hasan Çetin; Başhan, Mehmet; Keskin, Cumali; Toker, Zuhal; 0000-0001-6670-6469; 0000-0003-3758-0654; 0000-0003-1038-9091The fatty acid compositions of flowering tops of Hypericum perforatum L. and Hypericum retusum Aucher (Guttiferae) were analyzed by gas chromatography and gas chromatography-mass spectrometry. The major components were C16:0 (24.87%), C18:3 n-3 (21.94%), 3-OH-C18:0 (18.46%) and 3-OH-C14:0 (14.22%) for H. perforatum L. and 3-OH-C14:0 (28.29%), C18:0 (16.47%) and C16:0 (14.17%) for H. retusum Aucher. Besides widespread plant fatty acids, 3-hydroxy fatty acids, namely 3-hydroxytetradecanoic acid (3-OH-C14:0) and 3-hydroxyoctadecanoic acid (3-OH-C18:0) were also obtained.Öğe Mikro çoğaltılan dişi buttum (Pistacia khinjuk Stocks) ağacında ISSR belirteci ile somaklonal varyasyonun belirlenmesi(Iğdır Üniversitesi Fen Bilimleri Enstitüsü, 2023) Ersalı, Yusuf; Özen, Hasan Çetin; Tilkat, Engin; Onay, AhmetBitkilerde, biyotik ve abiyotik streslere karşı direnç istenenilen karakterler olup, mikroçoğaltım teknikleri ile elde edilen klonlarda bu genetik özelliklerin kaybolması istenmez. Mikroçoğaltım teknikleri ile klonlanmış bitkilerin genetik kararlılığını bilmek, ticari üretimde güvenli kullanımları hakkında önemli bir bilgi vermektedir. Bu çalışmada buttum (Pisatacia khinjuk Stoks ) dişi ağaçlarından (Ağaç1 ve Ağaç2) alınan sürgünler 5., 10., 15., 20. ve 24. alt kültürlerde anaç olarak kullanılmıştır. Donör bitkilerde (Ağaç 1 ve Ağaç 2) ve bunlardan alınan örneklerin rejeneresayon yoluyla elde edilen klonlarında somaklonal varyasyonun belirlenmesi için basit dizi tekrarı (ISSR) moleküler markörleri kullanılmıştır. Sürgün çoğalması, 2 mg/L 6-benziladenin (BA) içeren Murashige ve Skoog (MS) ortamında sağlanmıştır. Sürgünler, 2 mg/L 1-Naftalinasetik asit (NAA) içeren MS ortamında köklendirilmiştir. Seçilen 20 adet primer kullanılarak 675'i polimorfik (%72) olmak üzere toplam 925 bant elde edilmiştir. Polimorfizm oranı %36 (UBC841) ile %98 (UBC855) arasında değişmiştir. Benzerlik oranı, Ağaç 1 ile mikro-çoğaltılmış klonları arasında %74-79, Ağaç 2 ile mikro-çoğaltılmış klonları arasında %78-82 aralığında bulunmuştur.Öğe New oxetane-type taxanes from Taxus wallichiana Zucc(1993) Appendino, Giovanni; Özen, Hasan Çetin; Gariboldi, Pierluigi; Torregiani, Elisabetta; Gabetta, Bruno; Nizzola, Rita; Bombardelli, Ezio; 0000-0001-6670-6469The needles of Taxus wallichiana Zucc. gave the novel oxetane-type taxane diterpenoids 2 and 5, whose structures have been established on the basis of spectroscopic data and chemical reactions. The acid-catalysed rearrangement of 10-deacetylbaccatin III has been investigated.Öğe The effect of Cuscuta babylonica Aucher Cuscuta parasitism on the phenolic contents of Alhagi maurorum(Ersin YÜCEL, 2018) Asan, Hilal Surmuş; Özen, Hasan ÇetinParasitic plants are restrict the lives of earth plants. Cuscuta species are holoparasitic plants without leaves or roots. Water and nutrients are transferred through the haustorium from the vascular system of the host into the parasite. Parasitic plants are affected by host plant physiology because of similar hormonal pathways between parasite and host plants. Host plant secretes various phenolic compounds, as a response to parasitic plant. Alhagi, a plant genus from family Fabaceae, is widely distributed in many countries of Asia, Australia ve Europe. Abroad range of biological activities such as antioxidant, cardiovascular, antiulcer, antidiarrheal, antipyretic, anti-inflammatory, anti-rheumatic, antibacterial ve antifungal have been ascribed to different parts of Alhagi. In this study it is determined that the infection of Cuscuta babylonica Aucher Cuscutaceae on the phenolic compound changes of Alhagi maurorum by LC-MS/MS anlysis. As our results, it is revealed that the Cuscuta infection lead to an important increasing on the amount of chlorogenic acid 67.64 fold , apigenin 23.18 fold and quercetin 6.75 fold , besides improved the amount of hiperoside 3.94 fold , naringenin 2.92 , p-cumaric acid 2.28 fold , quinic acid 2.08 fold , coumarin 1.74 fold , trcafeic acid 1.61 fold , salicylic acid 1.40 fold , 4-OH benzoic acid 1.36 fold , malic acid 1.109 fold ve hesperidin 1.08 fold . The amount of kaemferol 5.04 fold , gallic acid 2.58 fold , vanillin 1.54 fold , tr-akonitic acid 2.41 fold , tannic acid 2.11 fold , rosmarinic acid 1.88 fold , and rutin 1.044 fold decreased when it is observed an significant decline the amount of protocatecholic acid 36.34 fold . Hesperetin is found only infected samples
