Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study

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dc.contributor.authorKarakok, Taliha
dc.contributor.authorGozukara, Melih Gaffar
dc.contributor.authorUygun Kizmaz, Yesim
dc.contributor.authorDemir, Yakup
dc.contributor.authorToruyenler Coskunpinar, Melike
dc.contributor.authorAltun Demircan, Serife
dc.contributor.authorArslan, Yusuf
dc.date.accessioned2024-04-24T17:27:52Z
dc.date.available2024-04-24T17:27:52Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: The objective of this study was to compare the risk factors and mortality rates of candidemia among patients with and without COVID-19 in the intensive care units (ICU).Materials and Methods: This study is a retrospective multicenter observational study, in ICUs of 12 hospitals (eight tertiary and four secondary hospitals) in Tarkiye. All adult patients (>18 years) hospitalized in ICUs and developed candidemia between 01.01.2020-31.12.2021 were included. The following data were collected: age, gender, nasopharyngeal swab SARS-CoV-2 PCR test, species of Candida (Candida albicans or non-albicans Candida), comorbidities, ICU stay, antibiotic use, corticosteroid, and anti-cytokine therapy, central venous catheter (CVC), abdominal surgery, parenteral nutrition, mechanical ventilation (MV), other cultures isolated Candida spp., echocardiography (ECO), mortality. Data from patients with or without COVID-19 were compared.Results: A total of 188 patients, 66 COVID-19 and 122 non-COVID-19, were included in the study. The median age of the patients was 69.5 and there were no differences between the groups. 185 (98.4%) patients had a history of antibiotic use. Sixteen patients, all from the COVID-19 group, had a history of anti-cytokine therapy. Corticosteroid use was higher in COVID-19 patients (p< 0.001). Intraabdominal surgery was higher in the non-COVID-19 group (p< 0.014). C. albicans was isolated from 36.7% of total patients and the remaining were non-albicans Candida species. The overall mortality was higher in COVID-19 patients (p= 0.014). Alzheimer's and malignancies were higher in non-COVID-19 patients. Intraabdominal surgery, MV, and CVC were higher in tertiary care hospitals whereas parenteral nutrition was higher in secondary care hospitals.Conclusion: Immunosuppressive treatments administered to COVID-19 patients pose a risk in terms of candidemia. Risk factors may differ between secondary and tertiary care hospitals. Preventable risk factors should be determined on a hospital basis and appropriate infection control measures should be taken.en_US
dc.identifier.doi10.5578/flora.20239716
dc.identifier.endpage465en_US
dc.identifier.issn1300-932X
dc.identifier.issn2602-2842
dc.identifier.issue3en_US
dc.identifier.startpage456en_US
dc.identifier.trdizinid1203880
dc.identifier.urihttps://doi.org/10.5578/flora.20239716
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1203880
dc.identifier.urihttps://hdl.handle.net/11468/20235
dc.identifier.volume28en_US
dc.identifier.wosWOS:001085015100013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.ispartofFlora Infeksiyon Hastaliklari Ve Klinik Mikrobiyoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCandidemiaen_US
dc.subjectCovid-19en_US
dc.subjectRisk Factorsen_US
dc.subjectIntensive Care Uniten_US
dc.titleAnalysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Studyen_US
dc.titleAnalysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study
dc.typeArticleen_US

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