Outcome of modified st jude total therapy 13a for childhood acute lymphoblastic leukemia in the southeast region of Turkey

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dc.contributor.authorKoç, Ahmet
dc.contributor.authorAyçiçek, Ali
dc.contributor.authorÖzdemir, Zeynep Canan
dc.contributor.authorSöker, Murat
dc.contributor.authorVarma, Mustafa
dc.contributor.orcid0000-0001-7940-2640
dc.date.accessioned2024-04-24T17:56:23Z
dc.date.available2024-04-24T17:56:23Z
dc.date.issued2013
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: To fill the gap in the current data on childhood acute lymphoblastic leukemia (ALL) in low-income and middle-income countries. METHODS: This study included 106 children between the ages of 1 and 17 years with newly diagnosed ALL monitored between 1999 and 2010. All the patients were treated with the modified St Jude Total 13A treatment plan at the Pediatric Hematology Clinic at Harran University. RESULTS: Sixty-eight (64.2%) patients were boys and 38 (35.8%) were girls. The median age at diagnosis was 5.9±3.7 years. Thirty-eight (35.8%) children were classified as standard risk, 53 (39.3%) were intermediate risk, and 15 (14.2%) were high risk. Thirteen (12.3%) children died in induction before the remission date (43 d of remission induction). Of all the 93 (100%) patients who completed remission induction therapy and whose bone marrow were in remission, 5 (4.7%) had a bone marrow relapse, 1 (0.9%) had a retinal relapse, and 5 (4.7%) had secondary acute myeloid leukemia. At a median follow-up of 44 months (range, 0.36 to 135.5 mo), the estimated 5-year overall survival and event-free survival were 77.4±5% and 68.9±6.5%, respectively. The estimated 5-year overall survival for boys and girls was 76.5±6% and 65.8±8%, respectively (P=0.182). CONCLUSIONS: St Jude Total 13A treatment protocols to treat childhood ALL can be successfully adapted, which suggests that such an approach may be useful in low socioeconomic regions; however, it should be noted that secondary leukemia can occur at a high rate.en_US
dc.identifier.citationKoç, A., Ayçiçek, A., Özdemir, Z. C., Söker, M. ve Varma, M. (2013). Outcome of modified st jude total therapy 13a for childhood acute lymphoblastic leukemia in the southeast region of Turkey. Journal of Pediatric Hematology/Oncology, 35(1), 36-41.
dc.identifier.doi10.1097/MPH.0b013e318271f43f
dc.identifier.endpage41en_US
dc.identifier.issn1077-4114
dc.identifier.issue1en_US
dc.identifier.pmid23138117
dc.identifier.scopus2-s2.0-84871792560
dc.identifier.scopusqualityQ3
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.1097/MPH.0b013e318271f43f
dc.identifier.urihttps://hdl.handle.net/11468/23489
dc.identifier.urihttps://journals.lww.com/jpho-online/fulltext/2013/01000/outcome_of_modified_st_jude_total_therapy_13a_for.7.aspx
dc.identifier.volume35en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofJournal of Pediatric Hematology/Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectB-lineage allen_US
dc.subjectChemotherapyen_US
dc.subjectChildhood allen_US
dc.subjectLeukemiaen_US
dc.subjectSecondary leukemiaen_US
dc.subjectT-lineage allen_US
dc.titleOutcome of modified st jude total therapy 13a for childhood acute lymphoblastic leukemia in the southeast region of Turkeyen_US
dc.titleOutcome of modified st jude total therapy 13a for childhood acute lymphoblastic leukemia in the southeast region of Turkey
dc.typeArticleen_US

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