Effects of nicotine on rat tongue mucosa: Histopathological and immunohistochemical analyses

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dc.contributor.authorEratilla V.
dc.contributor.authorUysal I.
dc.contributor.authorDeveci E.
dc.contributor.authorGüneş R.F.
dc.contributor.authorEratilla E.
dc.contributor.authorYildiz I.
dc.contributor.authorSöker S.
dc.date.accessioned2024-04-24T18:45:57Z
dc.date.available2024-04-24T18:45:57Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate the histopathological and immunohistochemical effects of systemically administered nicotine on rat tongue mucosa. STUDY DESIGN: Rats were assigned to one of two groups: the experimental group received nicotine systemically (nicotine sulphate 2 mg/kg subcutaneously daily for 28 days), while the rats in the control group were administered physiological saline (1.5 mL subcutaneously for 28 days). All animals were sacrificed at the end of the study, and tongue tissue samples were removed and prepared according to routine histological procedures. Sections were stained with hematoxylin and eosin and observed by light microscopy. Immunoreactivity of tongue mucosa was assessed with E-cadherin, collagen IV, and VEGF expression by immunohistochemical staining. RESULTS: There were significant differences in the average histopathological score between the nicotine-treated and untreated groups. Morphological changes, including inflammatory leukocyte infiltration and cellular desquamation, blood vessel dilation, hemorrhage, and epithelial degeneration, were noted. Further, E-cadherin expression was significantly decreased in the nicotine-treated group versus the untreated group. The nicotine treatment group showed an increase in collagen IV secondary papillae and basal cells. CONCLUSION: The increased level of VEGF expression in the nicotine-treated group may have affected endothelial cell apoptosis. © Science Printers and Publishers, Inc.en_US
dc.identifier.endpage22en_US
dc.identifier.issn0884-6812
dc.identifier.issue1en_US
dc.identifier.pmid27363062
dc.identifier.scopus2-s2.0-84961864478
dc.identifier.scopusqualityN/A
dc.identifier.startpage17en_US
dc.identifier.urihttps://hdl.handle.net/11468/24989
dc.identifier.volume38en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherScience Printers and Publishers Inc.en_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCollagen Type Iven_US
dc.subjectE-Cadherinen_US
dc.subjectNicotineen_US
dc.subjectTongueen_US
dc.subjectType Iv Collagenen_US
dc.subjectVascular Endothe-Lial Growth Factoren_US
dc.subjectVegfen_US
dc.titleEffects of nicotine on rat tongue mucosa: Histopathological and immunohistochemical analysesen_US
dc.titleEffects of nicotine on rat tongue mucosa: Histopathological and immunohistochemical analyses
dc.typeArticleen_US

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