Mutagenicity of Hypericum lysimachioides extracts

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dc.contributor.authorTolan, Veysel
dc.contributor.authorToker, Zuhal
dc.contributor.authorOzdemir, Sadin
dc.contributor.authorDemirci, Oezlem
dc.contributor.authorOtludil, Birol
dc.contributor.authorOezen, Hasan C.
dc.date.accessioned2024-04-24T17:20:32Z
dc.date.available2024-04-24T17:20:32Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractHypericum (Hypericaceae) species are extensively used in several fields such as traditional medicine, food and crop protection. Despite its usage in many fields, the identification of the genotoxic potential of this herb is still incomplete. In this study, we evaluated genotoxic effects of the petroleum ether, hexane, ethyl acetate, and methanol extract of Hypericum lysimachioides Boiss. var. lysimachioides by Ames Salmonella/microsome test and SOS chromotest. The mutagenic activity of Hypericum lysimachioides var. lysimachioides extracts was investigated by using Salmonella typhimurium strains TA98 and TA 100 and also the SOS chromotest with Escherichia coli PQ37 strain, with or without S9 metabolic activation. In this initial report we demonstrated that all extracts of H. lysimachioides var. lysimachioides showed significant mutagenic activity on both strains of Salmonella either with or without S9 mixture. No mutagenicity was found in the SOS chromotest either with or without S9 mixture. These results indicate a significant mutagenicity of the petroleum ether, hexane, ethyl acetate and methanol extracts of Hypericum lysimachioides var. lysimachioides in vitro. It can be suggested that quercetin and flavonol or their synergistic effects may be main mutagenic agents in the photopharmaceuticals Hypericum lysimachioides var. lysimachioides extract.en_US
dc.description.sponsorshipDicle University Scientific Research Foundation [DUBAP-03-EF-26]en_US
dc.description.sponsorshipThis paper is dedicated to Prof. Dr. Yavuz Ensari, who passed away on 14 August 2000. This work was supported by Dicle University Scientific Research Foundation (DUBAP-03-EF-26). The authors gratefully acknowledge helpful discussion and proofreading of the manuscript by Dr. Murat Kizil and Ibrahim. Tunik. The authors also thank Dr. Tahsin Sogut for his valuable contribution to statistical analyses.en_US
dc.identifier.doi10.3109/13880200902973811
dc.identifier.endpage1041en_US
dc.identifier.issn1388-0209
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-70350637688en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1035en_US
dc.identifier.urihttps://doi.org/10.3109/13880200902973811
dc.identifier.urihttps://hdl.handle.net/11468/19115
dc.identifier.volume47en_US
dc.identifier.wosWOS:000271561700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPharmaceutical Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypericum Lysimachioidesen_US
dc.subjectHypericum Extractsen_US
dc.subjectMutagenicityen_US
dc.subjectSalmonella Microsome Testen_US
dc.subjectSos Chromotesten_US
dc.titleMutagenicity of Hypericum lysimachioides extractsen_US
dc.typeArticleen_US

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