Clinical investigation: Thyroid function test abnormalities in cardiac arrest associated with acute coronary syndrome

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dc.contributor.authorIltumur, K
dc.contributor.authorOlmez, G
dc.contributor.authorAriturk, Z
dc.contributor.authorTaskesen, T
dc.contributor.authorToprak, N
dc.date.accessioned2024-04-24T17:14:53Z
dc.date.available2024-04-24T17:14:53Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction It is known that thyroid homeostasis is altered during the acute phase of cardiac arrest. However, it is not clear under what conditions, how and for how long these alterations occur. In the present study we examined thyroid function tests (TFTs) in the acute phase of cardiac arrest caused by acute coronary syndrome (ACS) and at the end of the first 2 months after the event. Method Fifty patients with cardiac arrest induced by ACS and 31 patients with acute myocardial infarction ( AMI) who did not require cardioversion or cardiopulmonary resuscitation were enrolled in the study, as were 40 healthy volunteers. The patients were divided into three groups based on duration of cardiac arrest (< 5 min, 5 - 10 min and > 10 min). Blood samples were collected for thyroid-stimulating hormone (TSH), triiodothyronine (T-3), free T-3, thyroxine (T-4), free T-4, troponin-I and creatine kinase-MB measurements. The blood samples for TFTs were taken at 72 hours and at 2 months after the acute event in the cardiac arrest and AMI groups, but only once in the control group. Results The T-3 and free T-3 levels at 72 hours in the cardiac arrest group were significantly lower than in both the AMI and control groups ( P < 0.0001). On the other hand, there were no significant differences between T-4, free T-4 and TSH levels between the three groups ( P > 0.05). At the 2-month evaluation, a dramatic improvement was observed in T-3 and free T-3 levels in the cardiac arrest group ( P < 0.0001). In those patients whose cardiac arrest duration was in excess of 10 min, levels of T-3, free T-3, T-4 and TSH were significantly lower than those in patients whose cardiac arrest duration was under 5 min ( P << 0.001, P < 0.001, P < 0.005 and P < 0.05, respectively). Conclusion TFTs are significantly altered in cardiac arrest induced by ACS. Changes in TFTs are even more pronounced in patients with longer periods of resuscitation. The changes in the surviving patients were characterized by euthyroid sick syndrome, and this improved by 2 months in those patients who did not progress into a vegetative state.en_US
dc.identifier.doi10.1186/cc3727
dc.identifier.endpageR424en_US
dc.identifier.issn1466-609X
dc.identifier.issn1364-8535
dc.identifier.issue4en_US
dc.identifier.pmid16137355
dc.identifier.startpageR416en_US
dc.identifier.urihttps://doi.org/10.1186/cc3727
dc.identifier.urihttps://hdl.handle.net/11468/18246
dc.identifier.volume9en_US
dc.identifier.wosWOS:000232151500018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofCritical Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleClinical investigation: Thyroid function test abnormalities in cardiac arrest associated with acute coronary syndromeen_US
dc.titleClinical investigation: Thyroid function test abnormalities in cardiac arrest associated with acute coronary syndrome
dc.typeArticleen_US

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