Effects of intralipid and caffeic acid phenyl esther (CAPE) against hepatotoxicity and nephrotoxicity caused by glyphosate isopropylamine (GI)

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dc.contributor.authorAlp, Harun
dc.contributor.authorPinar, Neslihan
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorSahan, Mustafa
dc.contributor.authorSenol, Serkan
dc.contributor.authorKarakus, Ali
dc.date.accessioned2024-04-24T17:14:45Z
dc.date.available2024-04-24T17:14:45Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was aimed to investigate the protective effects of caffeic acid phenyl esther (CAPE) and Intralipid (IL) against hepatotoxicity and nephrotoxicity caused by acute intoxication of glyphosate (N-phosphonomethyl) glycine) (GI) in rats. Forty-nine Wistar Albino rats were randomly divided into seven groups as: I, Control; II, Intralipid (IL) (18.6 mL/kg, orally); III, CAPE (10 mu mol/kg, intraperitoneally); IV, GI (4 mg/kg/day, intraperitoneally); V, GI + IL; VI, GI+CAPE; and VII, GI + IL + CAPE. Total antioxidant status (TAS) and total oxidant status (TOS) levels were measured in serum samples. Tissues were analyzed with hematoxylin and eosin (H&E) staining protocol. Bcl-2, Bax, and caspase-3 were evaluated by immunohistochemical method. The results revealed that, in hepatic tissues, the TAS levels were lower and the TOS levels were higher in the GI group compared to other groups. In renal tissues, the TAS levels were significantly lower in the GI group than in the control, IL, CAPE, and GI + IL + CAPE groups. The TOS levels were significantly higher in the GI group than in the control group. Moreover, histopathological analysis revealed severe hepatotoxicity in the GI group. In the GI + CAPE + IL group, hepatotoxicity recovered significantly. Nephrotoxicity was also observed in the GI group and moderately reduced in the GI + CAPE group. Biochemical results were confirmed by histopathologic examination. The results also revealed that CAPE and IL, due to their antioxidant effects, have a decreasing effect against both hepatotoxicity and nephrotoxicity caused by GI. Therefore, CAPE and IL may function as potential agents for supportive therapy since they decrease organ damage, or may facilitate the therapeutic effects of the routine treatment of patients with GI poisoning.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Coordination [1206M0127]en_US
dc.description.sponsorshipThis study was supported by Mustafa Kemal University Scientific Research Project Coordination (ID no. 1206M0127).en_US
dc.identifier.doi10.1177/1721727X16630318
dc.identifier.endpage9en_US
dc.identifier.issn1721-727X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84966687371
dc.identifier.scopusqualityQ4
dc.identifier.startpage3en_US
dc.identifier.urihttps://doi.org/10.1177/1721727X16630318
dc.identifier.urihttps://hdl.handle.net/11468/18174
dc.identifier.volume14en_US
dc.identifier.wosWOS:000372793000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofEuropean Journal of Inflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaffeic Acid Phenyl Esther (Cape)en_US
dc.subjectGlyphosate (N-Phosphonomethyl)Glycine)en_US
dc.subjectHepatotoxicityen_US
dc.subjectIntralipiden_US
dc.subjectNephrotoxicityen_US
dc.subjectOxidative Stressen_US
dc.titleEffects of intralipid and caffeic acid phenyl esther (CAPE) against hepatotoxicity and nephrotoxicity caused by glyphosate isopropylamine (GI)en_US
dc.titleEffects of intralipid and caffeic acid phenyl esther (CAPE) against hepatotoxicity and nephrotoxicity caused by glyphosate isopropylamine (GI)
dc.typeArticleen_US

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