Clinical and virological features of acute hepatic exacerbations in patients with chronic hepatitis B virus infection

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dc.authorid0000-0003-2137-7934en_US
dc.contributor.authorBeştaş, Remzi
dc.contributor.authorYalçın, Kendal
dc.date.accessioned2022-11-30T06:48:26Z
dc.date.available2022-11-30T06:48:26Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground and aim: In this study, we aimed to perform a comprehensive analysis of patients with acute hepatic flares observed during the course of chronic hepatitis B infection in order to provide early diagnosis, management, and best characterization of this unique group of hepatitis B patients. Patients and methods: The study was designed in a retrospective and prospective manner. Chronic hepatitis B patients with acute hepatic flares, admitted to the Department of Gastroenterology and Hepatology were enrolled in the study. Demographic, clinical, biochemical, and virological findings were recorded via pre-prepared forms. Results: The study was conducted on 125 patients. The mean age was 34.08 +/- 12.68 and the male to female ratio was determined as 2.28. Over 117 patients (93.6%) had at least one symptom. The most common symptoms and signs were fatigue (81.6%), anorexia (64%), jaundice (60%), and nausea (52%). Anti-HBc immunoglobulin M (IgM) antibody was detected in 24 patients (19.2%) and serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) was positive in 107 (85.6%) patients. The most common cause of exacerbations was spontaneous hepatic flares (80.8%). Conclusion: According to the results of this single-center study, acute hepatic exacerbations are more common in young men. The disease usually presents with non-specific symptoms and jaundice is the most common finding. As a sign of intensive inflammation and hepatocellular injury, serum ferritin levels seem to be high. Serum HBV DNA and anti-HBc IgM positivity with elevated alpha-fetoprotein (AFP) levels are presenting features of acute hepatic exacerbations.en_US
dc.identifier.citationBeştaş, R. ve Yalçın, K. (2021). Clinical and virological features of acute hepatic exacerbations in patients with chronic hepatitis B virus infection. Cureus, 13(6), 1-7.en_US
dc.identifier.doi10.7759/cureus.15937
dc.identifier.endpage7en_US
dc.identifier.issn2168-8184
dc.identifier.issue6en_US
dc.identifier.pmid34194888
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.cureus.com/articles/62096-clinical-and-virological-features-of-acute-hepatic-exacerbations-in-patients-with-chronic-hepatitis-b-virus-infection
dc.identifier.urihttps://hdl.handle.net/11468/10898
dc.identifier.volume13en_US
dc.identifier.wosWOS:000667344900006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorYalçın, Kendal
dc.language.isoenen_US
dc.publisherCureus Inc.en_US
dc.relation.ispartofCureus
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic hepatitis b infectionen_US
dc.subjectHepatic exacerbationen_US
dc.subjectHepatitis B virusen_US
dc.subjectFlareen_US
dc.subjectClinicen_US
dc.titleClinical and virological features of acute hepatic exacerbations in patients with chronic hepatitis B virus infectionen_US
dc.titleClinical and virological features of acute hepatic exacerbations in patients with chronic hepatitis B virus infection
dc.typeArticleen_US

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