The Protective Effect of Intratympanic Dexamethasone on Streptomycin Ototoxicity in Rats

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dc.contributor.authorGul, Aylin
dc.contributor.authorSengul, Engin
dc.contributor.authorYilmaz, Beyhan
dc.contributor.authorOzkurt, Fazil Emre
dc.contributor.authorAkdag, Mehmet
dc.contributor.authorKeles, Aysenur
dc.contributor.authorTopcu, Ismail
dc.date.accessioned2024-04-24T17:14:33Z
dc.date.available2024-04-24T17:14:33Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this experimental study was to investigate the protective role of intratympanically administered dexamethasone on the inner ears of rats that were exposed to streptomycin ototoxicity. Twenty-four adult Wistar albino rats were separated into 4 groups: Group 1 (only streptomycin), Group 2 (only intratympanic dexamethasone), Group 3 (streptomycin and intratympanic dexamethasone), and Group 4 (streptomycin and intratympanic saline). All rats were evaluated with distortion product otoacoustic emissions (DPOAE) tests before the start of treatment and on the day it ended. On the 45th day, after the final DPOAE tests, animals of all groups were sacrificed under general anesthesia. The differences between the amplitudes of DPOAE results were determined, and hearing results were statistically analyzed. Also, the cochleas of each rat were histopathologically evaluated under a light microscope with hematoxylin and eosin staining. In the intratympanic dexamethasone group it was observed that cochlear hair cells were mostly protected. No significant difference was seen between the DPOAE results before and after treatment (p > 0.05). On the other hand, loss was observed in the hearing functions and hair cells of the rats that received streptomycin and streptomycin plus intratympanic saline (p < 0.05). In the streptomycin plus intratympanic dexamethasone group, the cochlear hair cells were partially protected. A significant difference was observed when the DPOAE results (DP-grams) of the streptomycin plus intratypmanic dexamethasone group were compared to those of the streptomycin plus intratympanic saline group (p < 0.05). After the experimental study, ototoxic effects of the administration of streptomycin and intratympanic dexamethasone were observed on the rats' cochlear hair cells. We conclude that intratympanic dexamethasone has protective effects against this cochlear damage in rats.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship of the English editing of this manuscript.en_US
dc.identifier.doi10.1177/014556131709600603
dc.identifier.endpageE17en_US
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue6en_US
dc.identifier.pmid28636736
dc.identifier.startpageE12en_US
dc.identifier.urihttps://doi.org/10.1177/014556131709600603
dc.identifier.urihttps://hdl.handle.net/11468/18053
dc.identifier.volume96en_US
dc.identifier.wosWOS:000471623900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofEnt-Ear Nose & Throat Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe Protective Effect of Intratympanic Dexamethasone on Streptomycin Ototoxicity in Ratsen_US
dc.titleThe Protective Effect of Intratympanic Dexamethasone on Streptomycin Ototoxicity in Rats
dc.typeArticleen_US

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