The effects of nitric oxide on esophageal alkali burns

Basit Öğe Kaydı
dc.contributor.authorYagmur Y.
dc.contributor.authorOzturk H.
dc.contributor.authorKara I.H.
dc.contributor.authorKiraz M.
dc.date.accessioned2024-04-24T17:58:51Z
dc.date.available2024-04-24T17:58:51Z
dc.date.issued1999
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this experimental study was to evaluate the effects of nitric oxide on esophageal alkali burns. Thirty Spraque-Dawley rats weighting between 225 and 250 gram were used. Rats were randomly divided into three groups. In Group I rats (control), the esophageal lumen was washed with normal saline, in Group 2 the distal esophagus was burned with 50% NaOH solution as described by Gehanno and in Group 3 the esophageal lumen was washed with L-Arginine Methyl Ester (10 mg/kg) following esophageal burning. All rats were killed at 21 days and histopathologically evaluated for submucosal collagen increase, muscularis mucosa and tunica muscularis damage. There was no submucosal collagen increase, muscularis mucosa or tunica muscularis damage in Group 1. There was a significant difference for in submucosal collagen increase, muscularis mucosa and tunica muscularis damage when Group 2 was compared with Group 1 (p<0.0001, p<0.0001, p<0.0001) and when Group 3 was compared to Group 1 (p<0.001, p<0.05, p=0.05), There were also significant differences in the three parameters when Group 2 was compared with Group 3 (p<0.003, p<0.05, p<0.001). Nitric oxide may reduce submucosal collagen synthesis, muscularis mucosa and tunica muscularis damage in esophageal alkali burns but its effect in the prevention of stricture is not known.en_US
dc.identifier.endpage189en_US
dc.identifier.issn1300-4948
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0032731710en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://hdl.handle.net/11468/24129
dc.identifier.volume10en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherTurkish Society of Gastroenterologyen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlkali Burns Of The Esophagusen_US
dc.subjectEsophageal Strictureen_US
dc.subjectNitric Oxideen_US
dc.subjectSynthesis Of Collagenen_US
dc.titleThe effects of nitric oxide on esophageal alkali burnsen_US
dc.title.alternativeDeneysel alkali ozofagus yaniklarinda nitrik oksitin etkisien_US
dc.typeArticleen_US

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