The effects of nitric oxide on esophageal alkali burns
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Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Society of Gastroenterology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this experimental study was to evaluate the effects of nitric oxide on esophageal alkali burns. Thirty Spraque-Dawley rats weighting between 225 and 250 gram were used. Rats were randomly divided into three groups. In Group I rats (control), the esophageal lumen was washed with normal saline, in Group 2 the distal esophagus was burned with 50% NaOH solution as described by Gehanno and in Group 3 the esophageal lumen was washed with L-Arginine Methyl Ester (10 mg/kg) following esophageal burning. All rats were killed at 21 days and histopathologically evaluated for submucosal collagen increase, muscularis mucosa and tunica muscularis damage. There was no submucosal collagen increase, muscularis mucosa or tunica muscularis damage in Group 1. There was a significant difference for in submucosal collagen increase, muscularis mucosa and tunica muscularis damage when Group 2 was compared with Group 1 (p<0.0001, p<0.0001, p<0.0001) and when Group 3 was compared to Group 1 (p<0.001, p<0.05, p=0.05), There were also significant differences in the three parameters when Group 2 was compared with Group 3 (p<0.003, p<0.05, p<0.001). Nitric oxide may reduce submucosal collagen synthesis, muscularis mucosa and tunica muscularis damage in esophageal alkali burns but its effect in the prevention of stricture is not known.
Açıklama
Anahtar Kelimeler
Alkali Burns Of The Esophagus, Esophageal Stricture, Nitric Oxide, Synthesis Of Collagen
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
10
Sayı
3
