Effects of the changes between pre- and post-treatment 18F-FDG PET-CT volumetric parameters on overall survival in pleural mesothelioma

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dc.contributor.authorTuzun, Faris
dc.contributor.authorEbinc, Senar
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorKaplan, Ihsan
dc.contributor.authorKomek, Halil
dc.contributor.authorOruc, Zeynep
dc.contributor.authorTuzcu, Sadiye Kemal
dc.date.accessioned2024-04-24T17:27:57Z
dc.date.available2024-04-24T17:27:57Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction. This study aimed to examine the efficacy of positron emission tomography in fusion with computed tomography (PET-CT) parameters in predicting survival outcomes for patients with malignant pleural mesothelioma.Material and methods. This study retrospectively evaluated the data of 250 patients who were followed up after a diagnosis of malignant pleural mesothelioma. The relationship of pre-treatment [maximum standardized uptake value (SUVmax1), metabolic tumor volume (MTV1), total lesion glycolysis (TLG1), tumor/background (TBR1), pleural thickness1), post-treatment (SUVmax2, MTV2, TLG2, TBR2, pleural thickness2], and APET-CT parameters with survival was retrospectively evaluated in 36 patients whose pre-and post-treatment CT scan examinations were complete.Results. The median age of the patients was 57.5 years, ranging from 35 to 76. Median follow-up time was 16 months, with a range of 7 to 42 months. Median survival was calculated as 18.8 months for all patients. Based on the determined cut-off values, overall survival was determined as 29.9 months in patients with TLG2 <= 158 compared to 16 months in patients with TLG2 > 158 (p = 0.009) and as 30.9 months in patients with ATLG <= -62.58 compared to 16 months in patients with ATLG > -62.58 (p = 0.001). In addition, median overall survival (OS) was determined as 29.9 months in patients with MTV2 <= 63.9 compared to 16 months in patients with MTV2 > 63.9 (p = 0.007) and as 29.9 months in patients with AMTV <=-54.03 compared to 16 months in patients with AMTV > -54.03 (p = 0.002). When evaluated with respect to TBR2; median OS was 29.9 months in patients with TBR2 <= 1.84 compared to 16 months in patients with TBR2 > 1.84 (p = 0.039).Conclusions. Our research findings indicate a correlation between OS and volumetric PET-CT measures, specifically TLG and MTV.en_US
dc.identifier.doi10.5603/OCP.2023.0022
dc.identifier.endpage317en_US
dc.identifier.issn2450-1654
dc.identifier.issn2450-6478
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85175584407
dc.identifier.scopusqualityQ4
dc.identifier.startpage309en_US
dc.identifier.urihttps://doi.org/10.5603/OCP.2023.0022
dc.identifier.urihttps://hdl.handle.net/11468/20268
dc.identifier.volume19en_US
dc.identifier.wosWOS:001099825700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofOncology in Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMesotheliomaen_US
dc.subject18f-Fdg Pet-Cten_US
dc.subjectVolumetric Parametersen_US
dc.titleEffects of the changes between pre- and post-treatment 18F-FDG PET-CT volumetric parameters on overall survival in pleural mesotheliomaen_US
dc.titleEffects of the changes between pre- and post-treatment 18F-FDG PET-CT volumetric parameters on overall survival in pleural mesothelioma
dc.typeArticleen_US

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