Association of microRNA-related gene polymorphisms and idiopathic azoospermia in a south-east Turkey population

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dc.contributor.authorAy, Ozlem Izci
dc.contributor.authorBalkan, Mahmut
dc.contributor.authorErdal, Mehmet Emin
dc.contributor.authorRustemoglu, Aydin
dc.contributor.authorAtar, Murat
dc.contributor.authorHatipoglu, Namik Kemal
dc.contributor.authorBodakci, Mehmet Nuri
dc.date.accessioned2024-04-24T17:07:45Z
dc.date.available2024-04-24T17:07:45Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractMicroRNAs (miRNAs) are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression. Although it is reported in many studies that there are associations between alterations of miRNA homeostasis and pathological conditions such as cancer, psychiatric and neurological diseases, cardiovascular disease and autoimmune disease, the effects of common genetic variants of these genes on male infertility are unclear. To better understand this effect, we performed a case-control study including a total of 108 infertile men with idiopathic azoospermia and 125 fertile control subjects. Real-time polymerase chain reaction was used to genotype six single-nucleotide polymorphisms (SNPs) of microRNA biogenesis pathway genes and the associations between individual and combined genotypes and idiopathic azoospermia were analysed. The results showed significant difference between the individual AA genotype frequency of the GEMIN3 (rs197388) gene in the patient and control groups, indicating that the AA genotype may be considered as indicative of a higher predisposition to idiopathic azoospermia. The combined genotype analysis, including six SNPs, revealed statistically significant differences between the patients and control subjects for some combinations. For example, the frequency of genotype distributions of the AA\CA-CC-TT-AT genotype combination for the XPO5-RAN-DICER1GEMIN3 combined loci was significantly different, and it may be considered a predisposition to idiopathic azoospermia. According to the obtained results, both individual and combined genotypes of SNPs from miRNA genes may be used to predict the risk of male infertility with idiopathic azoospermia.en_US
dc.identifier.doi10.1080/13102818.2017.1281759
dc.identifier.endpage362en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85011279019
dc.identifier.scopusqualityQ3
dc.identifier.startpage356en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2017.1281759
dc.identifier.urihttps://hdl.handle.net/11468/16958
dc.identifier.volume31en_US
dc.identifier.wosWOS:000399341000018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMaleen_US
dc.subjectInfertilityen_US
dc.subjectMicrornaen_US
dc.subjectGeneen_US
dc.subjectSnpen_US
dc.subjectAzoospermiaen_US
dc.titleAssociation of microRNA-related gene polymorphisms and idiopathic azoospermia in a south-east Turkey populationen_US
dc.titleAssociation of microRNA-related gene polymorphisms and idiopathic azoospermia in a south-east Turkey population
dc.typeArticleen_US

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