The effect of amifostine on bacterial translocation after radiation induced acute enteritis

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dc.contributor.authorTas, Sukru
dc.contributor.authorOzkul, Faruk
dc.contributor.authorArik, Muhammet Kasim
dc.contributor.authorKiraz, Asli
dc.contributor.authorVural, Ahmet
dc.date.accessioned2024-04-24T17:18:10Z
dc.date.available2024-04-24T17:18:10Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractPURPOSE: To investigate the effects of amifostine on bacterial translocation and overgrowth in colonic flora after acute radiation enteritis in a rat model. METHODS: Thirty-two female Wistar albino rats were divided into four groups: Group-1 (n = 8): only normal saline was administered intraperitoneally. Group-2 (n = 8): first serum saline was administered intraperitoneally and 30 minutes later 20 Gy radiation was applied to abdominopelvic region. Group-3 (n = 8): only amifostine 200 ml/kg was administered intraperitoneally and radiation was not applied. Group-4 (n = 8): first amifostine 200 ml/kg was administered intraperitoneally and 30 minutes later 20 Gy radiation was applied to abdominopelvic region. On the 5th day after radiation, samples of mesenteric lymph tissues and cecal contents were taken by laparotomy for microbiological culture. RESULTS: Intraperitoneal amifostine administration significantly decreased the bacterial overgrowth related to radiation in colon but did not significantly decrease the bacterial translocation. CONCLUSION: Although not providing a full protection on the damaged mucosal barrier, amifostine significantly decreased the bacterial overgrowth in the cecal content after high dose radiation. There is a need to find out appropriate amifostine dose under different radiation applications avoiding bacterial translocation in gastrointestinal system.en_US
dc.identifier.doi10.1590/S0102-865020160030000002
dc.identifier.endpage160en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue3en_US
dc.identifier.pmid27050785
dc.identifier.startpage156en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160030000002
dc.identifier.urihttps://hdl.handle.net/11468/18643
dc.identifier.volume31en_US
dc.identifier.wosWOS:000374189100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmifostineen_US
dc.subjectBacterial Translocationen_US
dc.subjectEnteritisen_US
dc.subjectRadiationen_US
dc.subjectRatsen_US
dc.titleThe effect of amifostine on bacterial translocation after radiation induced acute enteritisen_US
dc.titleThe effect of amifostine on bacterial translocation after radiation induced acute enteritis
dc.typeArticleen_US

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