Cardiac troponin-I as a marker of myocardial dysfunction in children with septic shock

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dc.contributor.authorGurkan F.
dc.contributor.authorAlkaya A.
dc.contributor.authorEce A.
dc.contributor.authorHaspolat K.
dc.contributor.authorBoşnak Mehmet
dc.contributor.authorBilici M.
dc.contributor.authorKervancioglu M.
dc.date.accessioned2024-04-24T18:43:51Z
dc.date.available2024-04-24T18:43:51Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: Cardiac depression is well known in severe sepsis and septic shock. Our aim was to investigate the incidence of myocardial ischaemia as shown by cardiac troponin I (cTnI) levels in patients with septic shock and to evaluate the correlation with myocardial dysfunction measured by echocardiography. Methods: The study was performed in the paediatric intensive care unit in Dicle University Hospital, Turkey, between January 2001 and December 2002. Patients in septic shock, with a mean age of 6.4 ± 2.8 months, were simultaneously submitted to a two-dimensional echocardiogram and biochemical investigation on admission. Results: The mean serum cTnI level of the patients was 3.1 ± 2.6 ng/ml (0.01-9.80 ng/ml) and the mean LVEF value was calculated as 48% ± 11%. 21 patients (75%) had a cTnI level ?0.6 ng/ml, and 15 patients (54%) had a LVEF <0.5. For cTnI levels ?0.6 ng/ml, sensitivity and specificity were 93.3% and 46.2%, and positive and negative predictive values were 66.7% and 85.7% respectively. For cTnI values ?2.0 ng/ml, sensitivity and specificity were 86.7% and 76.9%, and positive and negative predictive values were 81.3% and 83.3%, respectively. There was a statistically significant relationship between LV dysfunction and cTnI positivity (r2 = 0.316, p = 0.002). No significant difference was found for the cTnI levels ?0.6 ng/ml between non-survivors and survivors (p <0.05). Conclusion: Myocardial ischaemia and cell injury seem to be common in patients with septic shock and correlate with left ventricular dysfunction. Measurement of cTnI may be an easy and practical tool for monitoring cardiac damage in critically ill septic patients.en_US
dc.identifier.endpage596en_US
dc.identifier.issn1424-7860
dc.identifier.issue39-40en_US
dc.identifier.pmid15592951
dc.identifier.scopus2-s2.0-9144220501
dc.identifier.scopusqualityQ1
dc.identifier.startpage593en_US
dc.identifier.urihttps://hdl.handle.net/11468/24421
dc.identifier.volume134en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSMW supporting associationen_US
dc.relation.ispartofSwiss Medical Weekly
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiac Troponin Ien_US
dc.subjectChilden_US
dc.subjectLvefen_US
dc.subjectMyocardial Dysfunctionen_US
dc.subjectSepsisen_US
dc.titleCardiac troponin-I as a marker of myocardial dysfunction in children with septic shocken_US
dc.titleCardiac troponin-I as a marker of myocardial dysfunction in children with septic shock
dc.typeArticleen_US

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