Protective Effects of Paricalcitol on Renal Ischemia/Reperfusion-Induced Lung Injury

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dc.contributor.authorYilmaz, Sureyya
dc.contributor.authorYildirim, Yasar
dc.contributor.authorKadiroglu, Ali Kemal
dc.contributor.authorBahadir, Veysi
dc.contributor.authorAydin, Emre
dc.contributor.authorAydin, Fatma Yilmaz
dc.contributor.authorKetani, Aydin
dc.date.accessioned2024-04-24T17:37:52Z
dc.date.available2024-04-24T17:37:52Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Acute kidney injury (AKI) is a common and important clinical challenge, and renal ischemia/reperfusion (I/R) injury is the major reason of AKI. Renal I/R can lead to lung injury, which is associated with increased mortality. This study was designed to evaluate whether paricalcitol may protect against lung injury following renal I/R injury via its antioxidant properties. STUDY DESIGN: Rats (n=7 per group) were divided into 4 groups: control, paricalcitol, I/R, and paricalcitol + I/R. Rats received daily intraperitoneal injection of paricalcitol (0.3 mu g/kg) for 5 days in the paricalcitol and paricalcitol + I/R groups. On day 6, rats were subjected to I/R injury (60 minutes of left renal artery occlusion followed by 60 minutes of reperfusion) after right nephrectomy. Renal function tests, oxidant and anti-oxidant parameters, and lung histology of both groups were examined. RESULTS: Pretreatment of rats with paricalcitol in the paricalcitol + I/R group significantly decreased serum urea and creatinine levels as compared with the I/R group (p < 0.05). Malondialdehyde (MDA) and total oxidant status (TOS) levels were significantly increased in serum and lung tissue of the I/R group as compared with the control and paricalcitol groups (p < 0.05). Rats treated with paricalcitol prior to I/R injury exhibited significant reduction in terms of serum and lung tissue TOS and MDA levels and significant increase in terms of serum and lung tissue nitric oxide and total antioxidant capacity levels (p < 0.05). The lung histopathological scores were significantly higher in the I/R group as compared with the paricalcitol + I/R group (p < 0.05). CONCLUSION: Paricalcitol may ameliorate renal I/Rinduced lung injury by attenuating oxidative stress.en_US
dc.description.sponsorshipDicle University Research Foundation [13-TF-58]en_US
dc.description.sponsorshipSupported by a grant from the Dicle University Research Foundation (Reference No. 13-TF-58) .en_US
dc.identifier.endpage573en_US
dc.identifier.issn0884-6812
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85171172432
dc.identifier.scopusqualityQ4
dc.identifier.startpage567en_US
dc.identifier.urihttps://hdl.handle.net/11468/21224
dc.identifier.volume43en_US
dc.identifier.wosWOS:000822438900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectLung Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectParicalcitolen_US
dc.subjectRatsen_US
dc.titleProtective Effects of Paricalcitol on Renal Ischemia/Reperfusion-Induced Lung Injuryen_US
dc.titleProtective Effects of Paricalcitol on Renal Ischemia/Reperfusion-Induced Lung Injury
dc.typeArticleen_US

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