FOUR-YEAR STUDY OF ENTECAVIR EFFICACY AND SAFETY IN NUCLEOS(T)IDE-NAIVE HBeAg POSITIVE CHRONIC HEPATITIS B PATIENTS

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dc.contributor.authorCelen, Mustafa Kemal
dc.contributor.authorDal, Tuba
dc.contributor.authorAyaz, Celal
dc.contributor.authorBayan, Kadim
dc.contributor.authorMert, Duygu
dc.contributor.authorDeveci, Ozcan
dc.contributor.authorOruc, Ebru Kursun
dc.date.accessioned2024-04-24T17:47:47Z
dc.date.available2024-04-24T17:47:47Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractEntecavir is a guanosine analogue with activity against hepatitis B virus. The aim of this 4-year trial was to evaluate entecavir treatment in nucleos(t)ide-naive HBeAg-positive chronic hepatitis B patients. Forty-nine patients received entecavir and nine of them withdrew from the trial at the end of week 96. The initial mean value of alanine aminotransferase was 79.4 +/- 41.5 IU/L, and at the end of the 4-year study period, 90% of patients had alanine aminotransferase values within the normal range. At week 96, 91.7% of patients had HBV DNA <300 copies; at month 48, 90% of patients had HBV DNA <50 IU/mL. HBeAg loss was recorded in 7.1% of patients at week 96 and in 12.5% at month 48. The rate of HBeAg seroconversion was 4.8% at week 96 and 7.5% at month 48. The rate of HBsAg seroconversion was 2.1% at week 96 and 2.5% at month 48. Entecavir as a potent and safe agent leading to continuous viral suppression proved to be safe and well tolerated therapy.en_US
dc.identifier.endpage36en_US
dc.identifier.issn0353-9466
dc.identifier.issn1333-9451
dc.identifier.issue1en_US
dc.identifier.pmid24974664
dc.identifier.startpage31en_US
dc.identifier.urihttps://hdl.handle.net/11468/22739
dc.identifier.volume53en_US
dc.identifier.wosWOS:000337216800005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSestre Milosrdnice Univ Hospitalen_US
dc.relation.ispartofActa Clinica Croatica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGuanine - Therapeutic Useen_US
dc.subjectHepatitis Ben_US
dc.subjectChronicen_US
dc.subjectAntiviral Agents - Therapyen_US
dc.titleFOUR-YEAR STUDY OF ENTECAVIR EFFICACY AND SAFETY IN NUCLEOS(T)IDE-NAIVE HBeAg POSITIVE CHRONIC HEPATITIS B PATIENTSen_US
dc.titleFOUR-YEAR STUDY OF ENTECAVIR EFFICACY AND SAFETY IN NUCLEOS(T)IDE-NAIVE HBeAg POSITIVE CHRONIC HEPATITIS B PATIENTS
dc.typeArticleen_US

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