Lokal ve sistemik borik asit uygulamasının titanyum implantların osseointegrasyon düzeylerine etkileri
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Fırat Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, sıçan tibialarında titanyum implantların osseointegrasyonuna lokal ve sistemik borik asit (BA) uygulamasının etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Titanyum implantlar, 32 sıçandan oluşan bir numune grubunun sağ tibia kemiğine cerrahi olarak entegre edildi. Sıçanlar dört tedavi grubuna ayrıldı: kontroller (CNT) (n=8), lokal BA (LBA) (n=8), sistemik BA (SBA) (n=8) ve sistemik ve lokal BA (SLBA) ( n=8). Kontroller, implant cerrahisinden sonra herhangi bir uygulama görmedi. LBA grubunda implant soketlerine lokal BA uygulandı, ardından implantlar soketlere yerleştirildi. SBA grubuna periton içi 8 mg/kg BA uygulandı. SLBA grubunda implant soketlerine lokal BA uygulandı, ardından implantlar soketlere yerleştirildi; ardından günde 8 mg/kg BA periton içi uygulandı. Deney periyodu 28 gün sürmüş, bundan sonra hayvanlara ötenazi uygulanmış ve implantlar çevredeki kemik dokusu ile birlite alınmıştır. Bulgular: Dekalsifiye olmayan histolojik yöntem kullanılarak kemik-implant kaynaşması (KİK) oranları (%) incelendi. SLBA ve SBA gruplarında KİK oranları, kontroller ve LBA grubu ile karşılaştırıldığında yüksekti (p<0.05) (p=0.004 p=0.002 p=0.011 p=0.013). SLBA grubunda KİK oranı SBA grubuna göre nümerik düzeyde olsa da istatistiksel düzeyde fark oluşturmadı (p>0.05 p=0.38). Sonuç: Bu çalışmanın sınırlamaları dahilinde, lokal uygulama ile sistemik ve sadece sistemik BA uygulamasının titanyum implantların osseointegrasyonunu artırabileceği sonucuna varılabilir.
Objective: In this study, we aimed to investigate the effects of local and systemic boric acid (BA) application on the osseointegration of titanium implants in rat tibias. Materials and Methods: The titanium implants were integrated surgically to the right tibias of a sample group of 32 rats. Rats were randomly divided into four treatment groups: controls (CNT) (n=8), local BA (LBA) (n=8), systemic BA (SBA) (n=8), and systemic and local BA (SLBA) (n=8) groups. Controls received no further treatment following implant surgery. In the LBA group, local BA was applied locally in the implant sockets, after which the implants were inserted in the sockets. In the SBA group, 8 mg/kg BA was applied intraperitoneally. In the SLBA group, local BA was applied locally in the implant sockets, after which the implants were inserted in the sockets; then, 8 mg/kg BA was applied intraperitoneally in a day. The experimental period lasted 28 days, after which the animals were euthanized and the implants collected, along with some surrounding bones from each rat. Results: Bone–implant connection (BIC) ratios (%) were observed using the non-decalcified histologic method. In the SLBA and SBA groups, BIC ratios were high compared with the controls and the LBA group (p<0.05) (p=0.004 p=0.002 p=0.011 p=0.013). In the SLBA group, the BIC ratio was higher than in the SBA animals numerically but not statistically (p>0.05 p=0.38). Conclusion: Within the limitations of this study, it may be concluded that systemic and systemic with local BA application could increase the osseointegration of titanium implants.
Objective: In this study, we aimed to investigate the effects of local and systemic boric acid (BA) application on the osseointegration of titanium implants in rat tibias. Materials and Methods: The titanium implants were integrated surgically to the right tibias of a sample group of 32 rats. Rats were randomly divided into four treatment groups: controls (CNT) (n=8), local BA (LBA) (n=8), systemic BA (SBA) (n=8), and systemic and local BA (SLBA) (n=8) groups. Controls received no further treatment following implant surgery. In the LBA group, local BA was applied locally in the implant sockets, after which the implants were inserted in the sockets. In the SBA group, 8 mg/kg BA was applied intraperitoneally. In the SLBA group, local BA was applied locally in the implant sockets, after which the implants were inserted in the sockets; then, 8 mg/kg BA was applied intraperitoneally in a day. The experimental period lasted 28 days, after which the animals were euthanized and the implants collected, along with some surrounding bones from each rat. Results: Bone–implant connection (BIC) ratios (%) were observed using the non-decalcified histologic method. In the SLBA and SBA groups, BIC ratios were high compared with the controls and the LBA group (p<0.05) (p=0.004 p=0.002 p=0.011 p=0.013). In the SLBA group, the BIC ratio was higher than in the SBA animals numerically but not statistically (p>0.05 p=0.38). Conclusion: Within the limitations of this study, it may be concluded that systemic and systemic with local BA application could increase the osseointegration of titanium implants.
Açıklama
Anahtar Kelimeler
Boric acid, Titanium implant, Osseointegrasyon, Kemik implant kaynaşması, Kemik implant teması, Osseointegration, Bone implant connection, Bone implant contact
Kaynak
Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
36
Sayı
1
Künye
Güneş, N., Bozoğlan, A. ve Dündar, S. (2022). Lokal ve sistemik borik asit uygulamasının titanyum implantların osseointegrasyon düzeylerine etkileri. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, 36(1), 25-30.
